Top 6 Antifungal and Antibacterial Topical Treatments in Canada (2025) — Vet-Trusted, Cat-Safe Creams, Ointments & Sprays with Guided Treatment Plans

Douxo S3 PYO Mousse (Ceva) is a veterinary‑grade foam formulated to target bacterial and fungal flare‑ups with actives optimized for pyoderma and Malassezia, and the mousse texture improves application and adherence on the coat and skin. As a premium, clinician‑focused product it typically carries a higher price than sprays or gels, but delivers superior targeted efficacy and handling compared with broad antiseptics, making it the market leader for prescribers seeking both potency and user‑friendly performance.

Bayer Miconahex + Triz Spray leverages Bayer’s pharmaceutical manufacturing standards to deliver a robust, clinically validated antiseptic combination that targets both fungi and bacteria, making it a go-to for more severe or persistent infections. Its technical strength and regulatory backing make it a higher-cost, higher-efficacy option compared with gentler or enzymatic products (for example, Zymox), and it’s often preferred where strong, predictable antimicrobial activity is required.

NaturVet Septiderm-V Skin Care Antiseptic Powder is an affordable antiseptic powder positioned for supportive skin care and mild irritations in cats, making it attractive for budget-conscious owners. It is priced lower than specialized veterinary powders like Veterinary Formula or technologically advanced options such as Zymox, and serves well as an adjunct or maintenance product after professional treatment. While cost-effective and accessible, it lacks the specialized enzymatic systems or targeted barrier-restoration ingredients found in premium veterinary lines like Douxo and may be insufficient alone for more serious fungal or bacterial conditions.

Vetericyn Plus is positioned as a gentle, broad-spectrum antimicrobial hydrogel designed to keep feline lesions moist while reducing surface bioburden; its non-antibiotic, non-steroidal approach makes it a go-to for owners who prefer an over-the-counter, low-risk option for spot treatment. Compared with enzyme- or steroid-containing competitors on this list, Vetericyn’s straightforward hydrogel formula is often more budget-friendly and widely available, making it a practical first-line adjunct for cat skin and coat issues that require frequent, gentle application.

Vetericyn Plus is positioned as a gentle, non‑antibiotic antimicrobial spray tailored for cats, favored for its broad-spectrum, no‑rinse formulation that supports wound cleansing without harsh ingredients — a technical advantage for frequent use on sensitive feline skin. Compared with enzyme‑based or steroid‑containing options on this list, Vetericyn’s non‑steroidal oxidizing approach reduces reliance on antibiotics and often represents a cost‑effective first step for superficial wounds and lesions before moving to prescription antifungal or antibacterial therapies.