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Top 5 Digestive Enzyme Supplements for Dogs in Canada (2025) — Expert-Picked Enzyme & Probiotic Formulas for Seniors, Sensitive Stomachs, and Pancreatitis Support

Published on Thursday, August 21, 2025

Digestive enzyme supplements for dogs are enzyme blends formulated to aid the breakdown of proteins, fats, and carbohydrates so pets absorb nutrients more efficiently and experience less digestive discomfort. In Canada, demand is driven by aging dog populations, growing awareness of exocrine pancreatic insufficiency and food sensitivities, and pet owners seeking non-prescription support for recurring loose stools, gas, or poor weight maintenance. Canadian buyers tend to prioritize veterinary recommendations, transparent ingredient sourcing, third-party testing, and convenient formats (chews, powders, or capsules) that fit daily routines. These supplements are commonly used to support seniors, dogs recovering from pancreatitis or EPI, and pets with mild food intolerances when used alongside veterinary guidance.

Quick Menu

1. Best Budget Digestive Support

2. Best Soft Chew Probiotic Blend

3. Best Premium Enzyme Formula

4. Best Powder Versatile Dose

5. Best Comprehensive Digestive Aid

1
BEST BUDGET DIGESTIVE SUPPORT

NaturVet Digestive Enzymes Plus Probiotics

NaturVet

NaturVet Digestive Enzymes Plus Probiotics is a budget-friendly, broad-spectrum formula combining multiple digestive enzymes with live probiotics to support digestion and stool quality in dogs. It earns a best-in-class spot for everyday value and reliable multi-component coverage compared with single-focus competitors on this list, offering a lower cost-per-dose than premium veterinarian-formulated options.

4.4
★★★★☆

  • Gentle digestion aid

  • Probiotic boost

  • Gentle digestion aid

  • Probiotic boost

Review Summary

84%

"Users commonly report noticeable improvement in digestion and firmer stools after regular use, with many praising the combination of enzymes and probiotics; a minority note inconsistent results or that it took several weeks to see benefits."

  • Tummy-hugging chew

  • Chewable formula combining broad-spectrum digestive enzymes and probiotics for daily use.

  • Tummy-hugging chew

  • Chewable formula combining broad-spectrum digestive enzymes and probiotics for daily use.

Self-Improvement & Personal Growth

Time-Saving Convenience

NaturVet Digestive Enzymes Plus Probiotics is a budget-friendly, broad-spectrum formula combining multiple digestive enzymes with live probiotics to support digestion and stool quality in dogs. It earns a best-in-class spot for everyday value and reliable multi-component coverage compared with single-focus competitors on this list, offering a lower cost-per-dose than premium veterinarian-formulated options.

  • Gentle digestion aid

  • Probiotic boost

  • Tummy-hugging chew

  • Chewable formula combining broad-spectrum digestive enzymes and probiotics for daily use.

  • Includes common enzymes like protease, amylase and lipase to aid digestion of protein, carbs and fats.

  • Gentle digestion aid

  • Probiotic boost

  • Tummy-hugging chew

  • Chewable formula combining broad-spectrum digestive enzymes and probiotics for daily use.

  • Includes common enzymes like protease, amylase and lipase to aid digestion of protein, carbs and fats.

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From 44.25$
2
BEST SOFT CHEW PROBIOTIC BLEND

Zesty Paws Probiotic Bites with Digestive Enzymes

Zesty Paws

Zesty Paws Probiotic Bites with Digestive Enzymes stands out for palatability and convenience as chewable soft treats that encourage consistent dosing, making it ideal for picky dogs. While slightly higher in price than powdered alternatives, its flavor-forward delivery and combined probiotic-enzyme profile compete well against tablet and powder options for owner adherence.

4.3
★★★★☆

  • Soft chewable bites

  • Bacon-approved treat

  • Soft chewable bites

  • Bacon-approved treat

Review Summary

80%

"Many pet owners like the tasty chew format and report reduced gas and improved stool quality, though some find it less effective for severe issues and a few cite price and occasional missing bites in shipments."

  • Daily gut balance

  • Soft chew format that pairs multiple probiotic strains with digestive enzymes for gut health.

  • Daily gut balance

  • Soft chew format that pairs multiple probiotic strains with digestive enzymes for gut health.

Recreational Enjoyment

Self-Improvement & Personal Growth

Zesty Paws Probiotic Bites with Digestive Enzymes stands out for palatability and convenience as chewable soft treats that encourage consistent dosing, making it ideal for picky dogs. While slightly higher in price than powdered alternatives, its flavor-forward delivery and combined probiotic-enzyme profile compete well against tablet and powder options for owner adherence.

  • Soft chewable bites

  • Bacon-approved treat

  • Daily gut balance

  • Soft chew format that pairs multiple probiotic strains with digestive enzymes for gut health.

  • Formulated for palatability to encourage consistent dosing and easy administration.

  • Soft chewable bites

  • Bacon-approved treat

  • Daily gut balance

  • Soft chew format that pairs multiple probiotic strains with digestive enzymes for gut health.

  • Formulated for palatability to encourage consistent dosing and easy administration.

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From 39.97$
3
BEST PREMIUM ENZYME FORMULA

Dr. Mercola Digestive Enzymes for Pets

Dr. Mercola

Dr. Mercola Digestive Enzymes for Pets is positioned as a premium, vet-formulated product emphasizing high-quality, clinically supported enzyme blends and ingredient transparency. It distinguishes itself on technical rigor and sourcing compared with mainstream brands, commanding a higher price but offering perceived clinical advantages for dogs with pronounced digestive sensitivities.

4.2
★★★★☆

  • Veterinarian-formulated

  • High-potency enzymes

  • Veterinarian-formulated

  • High-potency enzymes

Review Summary

78%

"Customers appreciate the high-quality formulation and report good digestive support for sensitive pets, but some users mention the product is pricey and saw only modest benefit in chronic cases."

  • No artificial fillers

  • Higher-end formula featuring plant-derived and proteolytic enzymes to support digestion.

  • No artificial fillers

  • Higher-end formula featuring plant-derived and proteolytic enzymes to support digestion.

Self-Improvement & Personal Growth

Increased Safety & Security

Dr. Mercola Digestive Enzymes for Pets is positioned as a premium, vet-formulated product emphasizing high-quality, clinically supported enzyme blends and ingredient transparency. It distinguishes itself on technical rigor and sourcing compared with mainstream brands, commanding a higher price but offering perceived clinical advantages for dogs with pronounced digestive sensitivities.

  • Veterinarian-formulated

  • High-potency enzymes

  • No artificial fillers

  • Higher-end formula featuring plant-derived and proteolytic enzymes to support digestion.

  • Often offered in powder or capsule forms to allow precise, weight-based dosing.

  • Veterinarian-formulated

  • High-potency enzymes

  • No artificial fillers

  • Higher-end formula featuring plant-derived and proteolytic enzymes to support digestion.

  • Often offered in powder or capsule forms to allow precise, weight-based dosing.

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From 70.99$
4
BEST POWDER VERSATILE DOSE

PetVitalix Digestive Enzyme Powder

PetVitalix Digestive Enzyme Powder

PetVitalix Digestive Enzyme Powder offers a finely dosed powder format that provides flexible, cost-effective dosing for multi-dog households and large breeds. Its financial advantage is clear when compared to chewable or individually packaged options on this list, and the powder form can be blended into food more easily than tablets or treats.

4
★★★★☆

  • Fine powder mix

  • Easy meal blend

  • Fine powder mix

  • Easy meal blend

Review Summary

72%

"Reviewers who used the powder consistently often report improved digestion and easier feedings, while a noticeable minority report no change or difficulty mixing into food."

  • Portion-friendly scoop

  • Fine powder that mixes into food for flexible dosing across dog sizes and picky eaters.

  • Portion-friendly scoop

  • Fine powder that mixes into food for flexible dosing across dog sizes and picky eaters.

Time-Saving Convenience

Self-Improvement & Personal Growth

PetVitalix Digestive Enzyme Powder offers a finely dosed powder format that provides flexible, cost-effective dosing for multi-dog households and large breeds. Its financial advantage is clear when compared to chewable or individually packaged options on this list, and the powder form can be blended into food more easily than tablets or treats.

  • Fine powder mix

  • Easy meal blend

  • Portion-friendly scoop

  • Fine powder that mixes into food for flexible dosing across dog sizes and picky eaters.

  • Contains core digestive enzymes (protease, amylase, lipase) plus supplemental enzymes like bromelain.

  • Fine powder mix

  • Easy meal blend

  • Portion-friendly scoop

  • Fine powder that mixes into food for flexible dosing across dog sizes and picky eaters.

  • Contains core digestive enzymes (protease, amylase, lipase) plus supplemental enzymes like bromelain.

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$15-30 CAD

5
BEST COMPREHENSIVE DIGESTIVE AID

Wholistic Pet Organics Digest-All Plus

Wholistic Pet Organics
🏠 Local Product

Wholistic Pet Organics Digest-All Plus prioritizes organic and whole-food ingredients with a formula that combines enzymes, probiotics, and digestive herbs to appeal to owners seeking natural sourcing. Though typically priced at a premium, its botanical approach and cleaner-ingredient positioning set it apart from more synthetic or value-focused competitors here.

4.3
★★★★☆

  • Organic ingredient blend

  • Broad-spectrum enzymes

  • Organic ingredient blend

  • Broad-spectrum enzymes

Review Summary

83%

"Owners frequently praise the broad-spectrum enzyme blend for helping with food sensitivities and reducing stool issues, though a few say results were slow or minimal for severe digestive disorders."

  • Garden-fresh vibe

  • Combines digestive enzymes with probiotics and prebiotic fibers for multi-pronged gut support.

  • Garden-fresh vibe

  • Combines digestive enzymes with probiotics and prebiotic fibers for multi-pronged gut support.

Self-Improvement & Personal Growth

Wholistic Pet Organics Digest-All Plus prioritizes organic and whole-food ingredients with a formula that combines enzymes, probiotics, and digestive herbs to appeal to owners seeking natural sourcing. Though typically priced at a premium, its botanical approach and cleaner-ingredient positioning set it apart from more synthetic or value-focused competitors here.

  • Organic ingredient blend

  • Broad-spectrum enzymes

  • Garden-fresh vibe

  • Combines digestive enzymes with probiotics and prebiotic fibers for multi-pronged gut support.

  • Formulated to support digestion of proteins, fats and carbohydrates with a broad enzyme profile.

  • Organic ingredient blend

  • Broad-spectrum enzymes

  • Garden-fresh vibe

  • Combines digestive enzymes with probiotics and prebiotic fibers for multi-pronged gut support.

  • Formulated to support digestion of proteins, fats and carbohydrates with a broad enzyme profile.

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From 39.99$

What the Research and Veterinary Guidance Say

Scientific and clinical literature shows clear benefit for targeted enzyme therapy in dogs with diagnosed exocrine pancreatic insufficiency (EPI) and supportive evidence for symptomatic dogs with impaired digestion. Research and veterinary practice stress matching the product type to the clinical situation, confirming ingredient potency, and combining enzymes with probiotics when indicated. Safety, correct dosing, and veterinary oversight are important because efficacy varies by product formulation and the underlying cause of digestive issues.

Pancreatic enzyme replacement is an established therapy for dogs with EPI: clinical reports show improved weight, appetite, and stool quality when appropriate enzyme preparations are used under veterinary supervision.

Multi-enzyme blends containing protease, lipase, and amylase can improve nutrient breakdown and stool consistency in dogs with partial digestive insufficiency, according to small clinical studies and practitioner observations.

Combining digestive enzymes with probiotics can support gut microbial balance and reduce symptoms such as gas and inconsistent stools; some trials report faster improvement in stool consistency versus enzymes alone.

Not all enzyme supplements are equivalent: formulation (enteric-coated vs non-coated), enzyme activity units, and stability affect real-world effectiveness, so label transparency and third-party testing matter.

Evidence for routine use in healthy dogs is limited; benefits are strongest in dogs with diagnosed or suspected deficiencies or in specific digestive conditions, reinforcing the need for a vet consult before long-term use.

In the Canadian market for 2025, these five options cover a range of needs and formats: NaturVet Digestive Enzymes Plus Probiotics, Zesty Paws Probiotic Bites with Digestive Enzymes, Dr. Mercola Digestive Enzymes for Pets, PetVitalix Digestive Enzyme Powder, and Wholistic Pet Organics Digest-All Plus. NaturVet Digestive Enzymes Plus Probiotics stands out as the best overall choice on this list for many owners because it balances enzyme strength with added probiotics, broad availability in Canada, and a reputation for consistent value and formulation. Zesty Paws is ideal for picky eaters who prefer flavored chews; Dr. Mercola is noted for premium ingredient sourcing; PetVitalix offers flexible powder dosing for custom portions; and Wholistic Pet Organics focuses on natural, whole-food–style blends. I hope you found what you were looking for — if you want to narrow results by dog age, condition, or format, or expand to vet-recommended prescription options, use the search to refine your results.

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  • Post Antibiotic Gut Support for Dogs

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