Heartgard Plus Auto-Ship
Heartgard Plus Auto-Ship remains a market leader for automatic heartworm prevention because of its long clinical track record, low per-dose cost and a simple monthly chewable formulation that minimizes missed doses through scheduled auto-ship. Compared with broader-spectrum subscriptions in this list, it is the most economical choice for owners focused primarily on heartworm and common intestinal roundworms, though it lacks the flea and tick coverage found in multi-parasite products like Simparica Trio or Revolution Plus.
Monthly peace-of-mind
Beef-flavored treat
Monthly peace-of-mind
Beef-flavored treat
Review Summary
"Longtime users praise Heartgard Plus Auto-Ship for reliable monthly heartworm protection and the convenience of automatic deliveries, with occasional complaints about subscription billing and price. Most report no noticeable side effects and high trust in its effectiveness."
Auto-ship ease
Monthly chewable focused on reliable heartworm prevention.
Auto-ship ease
Monthly chewable focused on reliable heartworm prevention.
Increased Safety & Security
Time-Saving Convenience
Heartgard Plus Auto-Ship remains a market leader for automatic heartworm prevention because of its long clinical track record, low per-dose cost and a simple monthly chewable formulation that minimizes missed doses through scheduled auto-ship. Compared with broader-spectrum subscriptions in this list, it is the most economical choice for owners focused primarily on heartworm and common intestinal roundworms, though it lacks the flea and tick coverage found in multi-parasite products like Simparica Trio or Revolution Plus.
Monthly peace-of-mind
Beef-flavored treat
Auto-ship ease
Monthly chewable focused on reliable heartworm prevention.
Also treats common intestinal round and hook worms.
Monthly peace-of-mind
Beef-flavored treat
Auto-ship ease
Monthly chewable focused on reliable heartworm prevention.
Also treats common intestinal round and hook worms.
$180-300 CAD
Interceptor Plus Subscription
Interceptor Plus Subscription holds a strong position by combining heartworm prevention with broad intestinal parasite and tapeworm control in a single monthly tablet, making the subscription financially attractive for owners who want consolidated deworming. Versus Heartgard Auto-Ship it delivers wider GI parasite coverage at comparable subscription convenience, but it does not include adult flea or tick control offered by products such as Simparica Trio or Revolution Plus, so some owners may still need an additional ectoparasite product.
Broad parasite shield
Tapeworm tango
Broad parasite shield
Tapeworm tango
Review Summary
"Interceptor Plus Subscription is commonly rated effective against heartworms and intestinal parasites, and buyers value the auto-delivery convenience; some note occasional gastrointestinal side effects or higher cost. Overall users find it dependable for multi-parasite control."
Never miss dose
Protects against heartworm and multiple intestinal parasites, including tapeworm.
Never miss dose
Protects against heartworm and multiple intestinal parasites, including tapeworm.
Increased Safety & Security
Time-Saving Convenience
Interceptor Plus Subscription holds a strong position by combining heartworm prevention with broad intestinal parasite and tapeworm control in a single monthly tablet, making the subscription financially attractive for owners who want consolidated deworming. Versus Heartgard Auto-Ship it delivers wider GI parasite coverage at comparable subscription convenience, but it does not include adult flea or tick control offered by products such as Simparica Trio or Revolution Plus, so some owners may still need an additional ectoparasite product.
Broad parasite shield
Tapeworm tango
Never miss dose
Protects against heartworm and multiple intestinal parasites, including tapeworm.
Palatable chewable with broad-spectrum parasite control.
Broad parasite shield
Tapeworm tango
Never miss dose
Protects against heartworm and multiple intestinal parasites, including tapeworm.
Palatable chewable with broad-spectrum parasite control.
$200-320 CAD
Sentinel Spectrum Auto-Delivery
Sentinel Spectrum Auto-Delivery is best-in-class for owners seeking a broad intestinal parasite and flea-lifecycle solution paired with heartworm prevention, and its auto-delivery reduces lapses while often replacing multiple individual purchases. Financially it can be a cost-effective alternative to buying separate dewormers and a flea control product, but technically it differs from tick-killing options like Simparica Trio and Revolution Plus because its flea protection targets the life cycle rather than rapidly killing adult fleas and ticks.
Flea-egg zapper
Worms and pests covered
Flea-egg zapper
Worms and pests covered
Review Summary
"Sentinel Spectrum Auto-Delivery is appreciated for broad-spectrum parasite protection and the ease of scheduled shipments, though some pet owners mention tablet size, price, or occasional minor adverse reactions. Reviews generally reflect satisfaction with its comprehensive coverage."
Auto-delivery calm
Combines heartworm prevention with flea control and intestinal parasite protection.
Auto-delivery calm
Combines heartworm prevention with flea control and intestinal parasite protection.
Increased Safety & Security
Time-Saving Convenience
Sentinel Spectrum Auto-Delivery is best-in-class for owners seeking a broad intestinal parasite and flea-lifecycle solution paired with heartworm prevention, and its auto-delivery reduces lapses while often replacing multiple individual purchases. Financially it can be a cost-effective alternative to buying separate dewormers and a flea control product, but technically it differs from tick-killing options like Simparica Trio and Revolution Plus because its flea protection targets the life cycle rather than rapidly killing adult fleas and ticks.
Flea-egg zapper
Worms and pests covered
Auto-delivery calm
Combines heartworm prevention with flea control and intestinal parasite protection.
Contains lufenuron to inhibit flea egg development for longer-term control.
Flea-egg zapper
Worms and pests covered
Auto-delivery calm
Combines heartworm prevention with flea control and intestinal parasite protection.
Contains lufenuron to inhibit flea egg development for longer-term control.
$220-360 CAD
Revolution Plus Auto-Refill
Revolution Plus Auto-Refill ranks as a market leader for comprehensive automatic protection by pairing heartworm prevention with broad-spectrum external parasite control (including fleas and many tick species) and coverage for several internal parasites, which simplifies care into one monthly dose. Although typically priced higher than heartworm-only subscriptions, its auto-refill program can be more cost-efficient overall by eliminating the need for separate spot-on or oral flea/tick products that would otherwise be purchased alongside items like Heartgard or Interceptor.
Topical power-up
Mite-fighting ally
Topical power-up
Mite-fighting ally
Review Summary
"Revolution Plus Auto-Refill earns positive marks for combining topical convenience with wide parasite protection and the simplicity of automatic refills; a minority report skin reactions or shipping/subscription hiccups. Most users find it effective and easy to use."
Refill on autopilot
Topical monthly treatment that covers heartworm, fleas, ticks and ear mites.
Refill on autopilot
Topical monthly treatment that covers heartworm, fleas, ticks and ear mites.
Increased Safety & Security
Time-Saving Convenience
Revolution Plus Auto-Refill ranks as a market leader for comprehensive automatic protection by pairing heartworm prevention with broad-spectrum external parasite control (including fleas and many tick species) and coverage for several internal parasites, which simplifies care into one monthly dose. Although typically priced higher than heartworm-only subscriptions, its auto-refill program can be more cost-efficient overall by eliminating the need for separate spot-on or oral flea/tick products that would otherwise be purchased alongside items like Heartgard or Interceptor.
Topical power-up
Mite-fighting ally
Refill on autopilot
Topical monthly treatment that covers heartworm, fleas, ticks and ear mites.
Includes an active ingredient for enhanced tick and flea efficacy.
Topical power-up
Mite-fighting ally
Refill on autopilot
Topical monthly treatment that covers heartworm, fleas, ticks and ear mites.
Includes an active ingredient for enhanced tick and flea efficacy.
$240-420 CAD
Simparica Trio Subscription
Simparica Trio Subscription is a market leader among automatic refill heartworm preventives for pet owners wanting the broadest single-tablet protection, combining heartworm prevention with fast-acting flea and tick control plus intestinal parasite treatment in a monthly chewable. Compared with Sentinel Spectrum it offers adult flea and tick killing and thus may replace the need for additional topical products, though that expanded coverage is reflected in a higher subscription price relative to narrow-spectrum options like Heartgard.
Fast flea killer
Triple-threat chew
Fast flea killer
Triple-threat chew
Review Summary
"Simparica Trio Subscription is frequently praised for high efficacy against fleas, ticks, heartworm and intestinal parasites and for palatable chewables, with rare reports of vomiting or lethargy. Overall reviewers rate it very highly for broad protection and subscription convenience."
Subscription serenity
Oral chewable combining flea, tick and heartworm protection in one dose.
Subscription serenity
Oral chewable combining flea, tick and heartworm protection in one dose.
Increased Safety & Security
Time-Saving Convenience
Simparica Trio Subscription is a market leader among automatic refill heartworm preventives for pet owners wanting the broadest single-tablet protection, combining heartworm prevention with fast-acting flea and tick control plus intestinal parasite treatment in a monthly chewable. Compared with Sentinel Spectrum it offers adult flea and tick killing and thus may replace the need for additional topical products, though that expanded coverage is reflected in a higher subscription price relative to narrow-spectrum options like Heartgard.
Fast flea killer
Triple-threat chew
Subscription serenity
Oral chewable combining flea, tick and heartworm protection in one dose.
Offers broad-spectrum efficacy including intestinal worms and multiple tick species.
Fast flea killer
Triple-threat chew
Subscription serenity
Oral chewable combining flea, tick and heartworm protection in one dose.
Offers broad-spectrum efficacy including intestinal worms and multiple tick species.
$300-480 CAD