Top 9 Over-the-Counter Medication Subscription Plans for Dogs in Canada (2025): Vet-Reviewed, Customizable Recurring Delivery for Joint, Flea & Digestive Care — Which One Suits Your Dog?

Simparica Trio holds a market-leader position for subscription use when comprehensive protection is required, combining sarolaner, moxidectin and pyrantel to cover fleas, multiple tick species, heartworm prevention and intestinal parasites in a single weight-based monthly chewable. Although typically positioned at a premium price, its thorough single-product spectrum reduces extra purchases and clinical complexity versus narrower agents, giving subscription services a technical and economic advantage by minimizing add-ons and claims.

Omega Alpha GlucosaPet Plus offers a pharmaceutical-style, multi-ingredient approach from a Canadian manufacturer that balances lab-grade assurance with subscription-friendly pricing for maintenance-level joint care. It sits between mass-market chews and clinical prescriptions by delivering more rigorous manufacturing standards than some consumer brands, while generally being less concentrated and less costly than veterinary-focused Nutramax or TRI-ACTA solutions.

FortiFlora holds a leading position because it combines a clinically documented probiotic strain with Purina's veterinary pedigree, making it a go-to OTC option for vets and owners who want reliable, evidence-backed digestive support. Compared with cheaper multi-ingredient options like NaturVet or palatable chews like Zesty Paws, FortiFlora trades broader ingredient breadth for proven single-strain performance and wide retail and subscription availability that supports predictable replenishment and vet-recommended pricing.

PetMedics is best-in-class for medically focused OTC dermal treatments, offering higher-potency over-the-counter formulations and clinician-curated instructional content that target flare-ups quickly and efficiently. Financially it undercuts larger multi-product boxes by concentrating on efficacy per dose, so pet owners seeking fast symptom control often see lower cost-per-effective-treatment than broader bundles like Wagwell or Zesty Paws.

Epi-Otic Advanced is a market-leading pH-balanced surfactant cleaner valued for gentle, regular ear maintenance and low per-dose cost, making it an economical subscription component for pet owners with dogs prone to mild irritation. Technically it does not deliver the same enzymatic or antifungal potency as Zymox, TrizULTRA, or Curaseb, but its affordability and broad availability make it a strong preventative option to pair with stronger OTC treatments when infections recur.

Chewy Autoship is the market leader for convenience and selection, offering deep discounts on recurring orders, broad brand availability, and automated replenishment that reduces the risk of running out of essential OTC dental supplies. Technically and financially it wins on scale — competitive pricing, frequent promotions, and the ability to mix-and-match veterinary and consumer products — though it’s less curated than specialty boxes like BarkBox or PetPlate. This option is ideal for owners who prefer cost-effective, flexible subscriptions and access to multiple proven dental brands in one recurring order.

CanPrev Mind-Pro is marketed as a targeted cognitive and mood support formula with higher-potency nutrients and specialized cofactors, making it a strong choice for subscribers who need a more concentrated, performance-oriented product. Its technical strengths are dose precision and ingredient synergy tailored for brain health, which commands a premium but can deliver better per-dose efficacy for some users, and subscription pricing often offsets the higher upfront cost. Compared with Natural Factors and Webber Naturals it is more nutritionally intensive, while Jamieson remains the more economical mass-market option.

Vetericyn Plus is notable for its broad clinical acceptance and multi-format availability (spray, gel), giving it a technical edge for varied wound types and making it a premium pick for subscription kits that prioritize veterinary-grade antimicrobial protection. Although it usually commands a higher price than simple antiseptics, its versatility reduces the number of separate products needed in a subscription, helping keep overall recurring costs down while delivering reliable outcomes.