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Top 5 Options in Canada for 2025: Immune and Antioxidant Vitamin Supplements for Dogs - Vet-Reviewed Guide to Boost Canine Resilience

Published on Thursday, August 21, 2025

Antioxidant-rich formulas with vitamins and botanicals support immune resilience and help protect cells from oxidative damage. This category includes chewables, soft chews, and vet-formulated powders that combine vitamins C and E, zinc, selenium, polyphenols, and omega-3s with targeted botanicals like turmeric and berry extracts. In Canada, shoppers favor products that are transparent about ingredients, lab-tested, and designed for life-stage needs—puppies, adults, and seniors—while addressing common local concerns such as seasonal allergies, urban pollution, and cold-weather stress. Practical format preferences (palatable chews and easy-to-dose options) and veterinary endorsements also drive purchasing decisions in Canadian pet markets.

Quick Menu

1. Best Allergy & Immune Support

2. Best Senior Immune + Joint Support

3. Best Affordable Multivitamin

4. Best All-in-One Antioxidant Blend

5. Best Veterinary-Grade Immune Support

1
BEST ALLERGY & IMMUNE SUPPORT

Zesty Paws Aller-Immune Bites

Zesty Paws

Zesty Paws Aller-Immune Bites are positioned as an allergy-focused immune support chew that combines quercetin and natural antioxidant ingredients in a palatable soft chew, making them appealing for pet owners who want targeted immune and antioxidant support without a prescription. Compared with the broader multivitamins on this list, Zesty Paws is more specialized for inflammation and allergy-related immune balance, and it typically offers a lower retail price than veterinary-grade options while providing convenient daily dosing.

4.5
★★★★☆
  • Immune antioxidant boost

  • Easy chewable doses

  • Immune antioxidant boost

  • Easy chewable doses

Review Summary

89%

"Users generally find these tasty chews help reduce seasonal allergy symptoms and support immune health, with many noting improvements in itching and coat. A minority report no change or mild digestive upset."

  • Snack-style delight

  • Soft chews formulated to support immune response and reduce allergy-related reactions.

  • Snack-style delight

  • Soft chews formulated to support immune response and reduce allergy-related reactions.

Recreational Enjoyment

Time-Saving Convenience

Self-Improvement & Personal Growth

Zesty Paws Aller-Immune Bites are positioned as an allergy-focused immune support chew that combines quercetin and natural antioxidant ingredients in a palatable soft chew, making them appealing for pet owners who want targeted immune and antioxidant support without a prescription. Compared with the broader multivitamins on this list, Zesty Paws is more specialized for inflammation and allergy-related immune balance, and it typically offers a lower retail price than veterinary-grade options while providing convenient daily dosing.

  • Immune antioxidant boost

  • Easy chewable doses

  • Snack-style delight

  • Soft chews formulated to support immune response and reduce allergy-related reactions.

  • Contains ingredients commonly used for immune support such as colostrum and egg-derived components.

  • Immune antioxidant boost

  • Easy chewable doses

  • Snack-style delight

  • Soft chews formulated to support immune response and reduce allergy-related reactions.

  • Contains ingredients commonly used for immune support such as colostrum and egg-derived components.

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From 39.97$
2
BEST SENIOR IMMUNE + JOINT SUPPORT

NaturVet VitaPet Senior Daily Vitamins Plus Glucosamine

NaturVet

NaturVet VitaPet Senior Daily Vitamins Plus Glucosamine targets older dogs by pairing essential vitamins and antioxidants with glucosamine for joint support, delivering age-focused immune maintenance in an affordable chewable format. Financially this product is a value-oriented choice for senior care, though it is less concentrated and less clinically tailored than veterinarian-directed formulas like Thorne Vet.

4.2
★★★★☆
  • Joint mobility aid

  • Daily senior vitamins

  • Joint mobility aid

  • Daily senior vitamins

Review Summary

84%

"Long-time users praise joint support and increased energy in senior dogs and appreciate the value, though some note the tablets can be large or hard to administer. A small portion report picky-eater refusal or occasional stomach upset."

  • Golden-years comfort

  • Senior-focused multivitamin that combines immune-supporting vitamins with glucosamine for joint health.

  • Golden-years comfort

  • Senior-focused multivitamin that combines immune-supporting vitamins with glucosamine for joint health.

Self-Improvement & Personal Growth

Time-Saving Convenience

NaturVet VitaPet Senior Daily Vitamins Plus Glucosamine targets older dogs by pairing essential vitamins and antioxidants with glucosamine for joint support, delivering age-focused immune maintenance in an affordable chewable format. Financially this product is a value-oriented choice for senior care, though it is less concentrated and less clinically tailored than veterinarian-directed formulas like Thorne Vet.

  • Joint mobility aid

  • Daily senior vitamins

  • Golden-years comfort

  • Senior-focused multivitamin that combines immune-supporting vitamins with glucosamine for joint health.

  • Chewable tablets designed to address mobility and age-related nutrient needs in older dogs.

  • Joint mobility aid

  • Daily senior vitamins

  • Golden-years comfort

  • Senior-focused multivitamin that combines immune-supporting vitamins with glucosamine for joint health.

  • Chewable tablets designed to address mobility and age-related nutrient needs in older dogs.

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From 33.48$
3
BEST AFFORDABLE MULTIVITAMIN

Nutri-Vet Multi-Vite Chewables

Nutri-Vet

Nutri-Vet Multi-Vite Chewables are an economical all-purpose daily multivitamin that includes key antioxidant and immune-supporting vitamins in an easy-to-administer chew, making them a pragmatic option for routine supplementation. Compared to premium or vet-grade competitors, Nutri-Vet emphasizes wide availability and low cost but offers a simpler ingredient profile and lower dosing specificity.

4.3
★★★★☆
  • Broad nutrient spectrum

  • Tasty chewables

  • Broad nutrient spectrum

  • Tasty chewables

Review Summary

86%

"Owners like the palatable chewables for daily multivitamin coverage and often report better coat and vitality; a few mention a strong smell or limited noticeable benefit. Generally considered an affordable, reliable option."

  • Pocket-friendly treats

  • Budget-friendly chewable multivitamin supplying essential vitamins and minerals for overall health.

  • Pocket-friendly treats

  • Budget-friendly chewable multivitamin supplying essential vitamins and minerals for overall health.

Recreational Enjoyment

Time-Saving Convenience

Self-Improvement & Personal Growth

Nutri-Vet Multi-Vite Chewables are an economical all-purpose daily multivitamin that includes key antioxidant and immune-supporting vitamins in an easy-to-administer chew, making them a pragmatic option for routine supplementation. Compared to premium or vet-grade competitors, Nutri-Vet emphasizes wide availability and low cost but offers a simpler ingredient profile and lower dosing specificity.

  • Broad nutrient spectrum

  • Tasty chewables

  • Pocket-friendly treats

  • Budget-friendly chewable multivitamin supplying essential vitamins and minerals for overall health.

  • Formulated to support skin, coat, and immune function with antioxidant nutrients.

  • Broad nutrient spectrum

  • Tasty chewables

  • Pocket-friendly treats

  • Budget-friendly chewable multivitamin supplying essential vitamins and minerals for overall health.

  • Formulated to support skin, coat, and immune function with antioxidant nutrients.

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From 26.99$
4
BEST ALL-IN-ONE ANTIOXIDANT BLEND

PetHonesty Multivitamin 10-in-1

Pet Honesty

PetHonesty Multivitamin 10-in-1 delivers a broad-spectrum formula combining vitamins, antioxidants, probiotics and omegas aimed at comprehensive immune and antioxidant support, positioned as a higher-value DTC option with strong ingredient transparency. It bridges the gap between mass-market chews and veterinary lines by offering a more complete ingredient set than basic multivitamins, though it remains less clinically concentrated and typically cheaper than strict professional-grade products.

4.4
★★★★☆
  • 10-in-1 coverage

  • Antioxidant-rich formula

  • 10-in-1 coverage

  • Antioxidant-rich formula

Review Summary

88%

"Buyers appreciate the broad-spectrum formula, transparent labeling, and that most dogs accept the soft chews; some users find results subtle or feel the product is pricier than generic alternatives. Overall well-regarded for comprehensive nutrients."

  • Flavor-packed goodness

  • 10-in-1 formula combining vitamins, antioxidants, omegas, and digestive support for whole-body benefits.

  • Flavor-packed goodness

  • 10-in-1 formula combining vitamins, antioxidants, omegas, and digestive support for whole-body benefits.

Self-Improvement & Personal Growth

Time-Saving Convenience

Recreational Enjoyment

PetHonesty Multivitamin 10-in-1 delivers a broad-spectrum formula combining vitamins, antioxidants, probiotics and omegas aimed at comprehensive immune and antioxidant support, positioned as a higher-value DTC option with strong ingredient transparency. It bridges the gap between mass-market chews and veterinary lines by offering a more complete ingredient set than basic multivitamins, though it remains less clinically concentrated and typically cheaper than strict professional-grade products.

  • 10-in-1 coverage

  • Antioxidant-rich formula

  • Flavor-packed goodness

  • 10-in-1 formula combining vitamins, antioxidants, omegas, and digestive support for whole-body benefits.

  • Targets immune health and oxidative stress with concentrated antioxidant ingredients.

  • 10-in-1 coverage

  • Antioxidant-rich formula

  • Flavor-packed goodness

  • 10-in-1 formula combining vitamins, antioxidants, omegas, and digestive support for whole-body benefits.

  • Targets immune health and oxidative stress with concentrated antioxidant ingredients.

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From 41.99$
5
BEST VETERINARY-GRADE IMMUNE SUPPORT

Thorne Vet Canine Basic Nutrients

Thorne Vet

Thorne Vet Canine Basic Nutrients is a veterinary-grade supplement formulated for clinicians and pet owners who need precise, research-backed nutrient levels and high purity, prioritizing measured immune and antioxidant support over palatability. Technically superior in raw ingredient testing and potency compared with consumer chewables, Thorne Vet is usually the most expensive option but offers the strongest quality assurance and dosing control for dogs with specific health needs.

4.6
★★★★☆
  • Vet-formulated purity

  • Complete foundational mix

  • Vet-formulated purity

  • Complete foundational mix

Review Summary

92%

"Consumers and veterinarians note the high-quality, pure ingredients and consistent immune and antioxidant support, with many reporting reliable results. The main drawbacks are higher cost and less widespread retail availability."

  • Lab-grade trust

  • Veterinary-formulated complete nutrient base offering bioavailable vitamins and minerals for dogs.

  • Lab-grade trust

  • Veterinary-formulated complete nutrient base offering bioavailable vitamins and minerals for dogs.

Self-Improvement & Personal Growth

Increased Safety & Security

Time-Saving Convenience

Thorne Vet Canine Basic Nutrients is a veterinary-grade supplement formulated for clinicians and pet owners who need precise, research-backed nutrient levels and high purity, prioritizing measured immune and antioxidant support over palatability. Technically superior in raw ingredient testing and potency compared with consumer chewables, Thorne Vet is usually the most expensive option but offers the strongest quality assurance and dosing control for dogs with specific health needs.

  • Vet-formulated purity

  • Complete foundational mix

  • Lab-grade trust

  • Veterinary-formulated complete nutrient base offering bioavailable vitamins and minerals for dogs.

  • Focuses on high-quality, clinically-oriented ingredients to support immune function and antioxidant defenses.

  • Vet-formulated purity

  • Complete foundational mix

  • Lab-grade trust

  • Veterinary-formulated complete nutrient base offering bioavailable vitamins and minerals for dogs.

  • Focuses on high-quality, clinically-oriented ingredients to support immune function and antioxidant defenses.

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$70-120 CAD

What the Research Says About Antioxidants and Canine Immunity

A growing body of veterinary nutrition research supports the role of antioxidants and certain vitamins and minerals in reducing oxidative stress and supporting immune function in dogs. Clinical and laboratory studies indicate that properly dosed antioxidants can lower biomarkers of oxidative damage, while omega-3 fatty acids and specific botanicals can modulate inflammatory responses. Evidence is strongest when supplements are used as part of an overall nutrition and wellness plan, ideally under veterinary guidance.

Vitamins C and E act as primary antioxidant nutrients that help neutralize free radicals and protect cell membranes in mammalian tissues.

Selenium and zinc are essential trace minerals involved in antioxidant enzyme systems and immune cell function; deficiency can impair immune responses.

Omega-3 fatty acids (EPA and DHA) have been shown in trials to reduce inflammatory markers and support immune balance in dogs with chronic inflammatory conditions.

Polyphenol-rich botanicals (for example, berry extracts and turmeric) provide complementary antioxidant actions; some studies report improved oxidative markers and mobility when used adjunctively.

Multi-nutrient formulations targeted to seniors frequently show benefits in reducing age-related oxidative stress and supporting mobility and overall vitality.

Best outcomes are reported when supplements are chosen based on ingredient quality, appropriate dosing, and after considering the dog's age, size, and health status; veterinarian consultation is recommended.

In the Canadian market for 2025, antioxidant-focused immune supplements offer practical tools to support canine resilience, with products tailored to different life stages and needs. The five options highlighted here—Zesty Paws Aller-Immune Bites, NaturVet VitaPet Senior Daily Vitamins Plus Glucosamine, Nutri-Vet Multi-Vite Chewables, PetHonesty Multivitamin 10-in-1, and Thorne Vet Canine Basic Nutrients—cover formats from tasty soft chews to vet-grade formulations. For overall purity, clinical formulation, and broad suitability, Thorne Vet Canine Basic Nutrients stands out as the best overall choice on this list for owners seeking a comprehensive, vet-focused option. I hope you found what you were looking for; use the site search to refine by ingredient, life stage, or delivery format, or expand your search if you want allergy-specific or breed-specific recommendations.

Discover More
  • Daily Multivitamin Supplements for Dogs
  • Puppy Multivitamin Supplements for Dogs
  • Senior Multivitamin Supplements for Dogs
  • Skin and Coat Vitamin Supplements for Dogs
  • Mineral and Electrolyte Blends for Dogs
  • Prenatal and Lactation Vitamin Supplements for Dogs
  • Single Vitamin Supplements for Dogs

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