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Top 5 Single-Ingredient Anthelmintic Options in Canada 2025 — Expert Guide to Targeted Intestinal Parasite Treatment

Published on Thursday, August 21, 2025

This category covers monotherapy anthelmintics — products formulated with a single active ingredient for targeted treatment of intestinal parasites in small animals. Monotherapy options are chosen when clinicians need predictable pharmacologic profiles, simpler drug interaction management, or precise withdrawal and dosing considerations for individual parasites. Consumers and veterinarians often prefer single-ingredient products when parasite susceptibility is known or when minimizing exposure to multiple actives matters for safety, breeding/production timing, or resistance-management strategies. In the Canadian market, supply, provincial regulations, and formulation (oral, topical, suspension, granule) influence preference, with many owners valuing clear labels, easy administration, and veterinary guidance.

Quick Menu

1. Best Single-Ingredient Fenbendazole

2. Combination Broad-Spectrum (Not Single-Ingredient)

3. Combination Milbemycin-Praziquantel (Not Single-Ingredient)

4. Topical Combination for Cats (Not Single-Ingredient)

5. Best Single-Ingredient Pyrantel Suspension

1
BEST SINGLE-INGREDIENT FENBENDAZOLE

Panacur Granules 22.2%

Panacur Granules 22.2%

Panacur Granules (fenbendazole) is a market-leading single‑ingredient benzimidazole trusted for targeted treatment of intestinal nematodes in small animals; its granular form allows precise dose titration for very small patients or multi‑animal dosing and is often cost‑effective per dose. Compared with the combination products in this list, Panacur's single active ingredient reduces unnecessary broad‑spectrum exposure and is preferred for focused therapy and resistance‑management strategies.

4.5
★★★★☆

  • Broad-spectrum

  • Multi-species safe

  • Broad-spectrum

  • Multi-species safe

Review Summary

89%

"Long‑term users report Panacur (fenbendazole) granules as a reliably effective broad‑spectrum dewormer with good safety; some note the texture/taste can be offputting but efficacy against a range of intestinal parasites is consistently praised."

  • Granule-friendly charm

  • Contains 22.2% fenbendazole effective against common nematodes and some larval stages of cestodes

  • Granule-friendly charm

  • Contains 22.2% fenbendazole effective against common nematodes and some larval stages of cestodes

Increased Safety & Security

Time-Saving Convenience

Panacur Granules (fenbendazole) is a market-leading single‑ingredient benzimidazole trusted for targeted treatment of intestinal nematodes in small animals; its granular form allows precise dose titration for very small patients or multi‑animal dosing and is often cost‑effective per dose. Compared with the combination products in this list, Panacur's single active ingredient reduces unnecessary broad‑spectrum exposure and is preferred for focused therapy and resistance‑management strategies.

  • Broad-spectrum

  • Multi-species safe

  • Granule-friendly charm

  • Contains 22.2% fenbendazole effective against common nematodes and some larval stages of cestodes

  • Granule formulation can be mixed with food for flexible dosing in dogs and cats

  • Broad-spectrum

  • Multi-species safe

  • Granule-friendly charm

  • Contains 22.2% fenbendazole effective against common nematodes and some larval stages of cestodes

  • Granule formulation can be mixed with food for flexible dosing in dogs and cats

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$25-60 CAD

2
COMBINATION BROAD-SPECTRUM (NOT SINGLE-INGREDIENT)

Drontal Plus Flavour Tablets

Drontal Plus Flavour Tablets

Drontal Plus Flavour Tablets provide broad‑spectrum, multi‑drug oral coverage in a single convenient dose, making them financially attractive for treating mixed infections quickly and improving owner compliance with flavoured tablets. For the single‑ingredient anthelmintic use case, Drontal offers technical superiority when immediate cestode and nematode coverage is required, but it lacks the targeted simplicity and lower selection pressure of single‑ingredient options like Panacur or Strongid.

4.3
★★★★☆

  • Triple-action

  • Kid-pleasing flavour

  • Triple-action

  • Kid-pleasing flavour

Review Summary

86%

"Owners frequently praise Drontal Plus tablets for rapid, broad‑spectrum efficacy (including tapeworms) and good palatability in dogs, with few adverse effects reported after repeated use."

  • Tableted convenience

  • Contains praziquantel and pyrantel (and febantel in some canine formulations) to target tapeworms and nematodes

  • Tableted convenience

  • Contains praziquantel and pyrantel (and febantel in some canine formulations) to target tapeworms and nematodes

Increased Safety & Security

Time-Saving Convenience

Drontal Plus Flavour Tablets provide broad‑spectrum, multi‑drug oral coverage in a single convenient dose, making them financially attractive for treating mixed infections quickly and improving owner compliance with flavoured tablets. For the single‑ingredient anthelmintic use case, Drontal offers technical superiority when immediate cestode and nematode coverage is required, but it lacks the targeted simplicity and lower selection pressure of single‑ingredient options like Panacur or Strongid.

  • Triple-action

  • Kid-pleasing flavour

  • Tableted convenience

  • Contains praziquantel and pyrantel (and febantel in some canine formulations) to target tapeworms and nematodes

  • Flavoured tablets improve palatability and ease single-dose administration

  • Triple-action

  • Kid-pleasing flavour

  • Tableted convenience

  • Contains praziquantel and pyrantel (and febantel in some canine formulations) to target tapeworms and nematodes

  • Flavoured tablets improve palatability and ease single-dose administration

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$25-60 CAD

3
COMBINATION MILBEMYCIN-PRAZIQUANTEL (NOT SINGLE-INGREDIENT)

Milbemax Tablets for Dogs

Milbemax Tablets for Dogs

Milbemax combines milbemycin oxime and praziquantel in a palatable chewable designed to deliver reliable control of intestinal parasites (and heartworm prevention in some regions), offering high owner compliance and a one‑product solution. Compared with single‑ingredient therapies on this list, Milbemax trades off dosing flexibility and potentially lower per‑dose cost for broader spectrum coverage in a single administration, which can be more expensive but clinically convenient for mixed infestations.

4.2
★★★★☆

  • Dual-protection

  • Chewable tasty

  • Dual-protection

  • Chewable tasty

Review Summary

84%

"Milbemax is generally rated highly for effective, reliable control of common intestinal parasites in dogs; reviewers note occasional mild GI upset but overall sustained satisfaction with results."

  • Weight-based dosing

  • Combines milbemycin oxime and praziquantel for control of nematodes and cestodes

  • Weight-based dosing

  • Combines milbemycin oxime and praziquantel for control of nematodes and cestodes

Increased Safety & Security

Time-Saving Convenience

Milbemax combines milbemycin oxime and praziquantel in a palatable chewable designed to deliver reliable control of intestinal parasites (and heartworm prevention in some regions), offering high owner compliance and a one‑product solution. Compared with single‑ingredient therapies on this list, Milbemax trades off dosing flexibility and potentially lower per‑dose cost for broader spectrum coverage in a single administration, which can be more expensive but clinically convenient for mixed infestations.

  • Dual-protection

  • Chewable tasty

  • Weight-based dosing

  • Combines milbemycin oxime and praziquantel for control of nematodes and cestodes

  • Tablets are weight-based with formulations for small to large dogs

  • Dual-protection

  • Chewable tasty

  • Weight-based dosing

  • Combines milbemycin oxime and praziquantel for control of nematodes and cestodes

  • Tablets are weight-based with formulations for small to large dogs

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$35-90 CAD

4
TOPICAL COMBINATION FOR CATS (NOT SINGLE-INGREDIENT)

Profender Topical Solution for Cats

Profender Topical Solution for Cats

Profender is a topical emodepside‑praziquantel formulation that excels for feline patients that resist oral dosing, providing effective intestinal parasite control with minimal handling and a favorable safety profile. Although not a single‑ingredient product, Profender's route of administration and reduced need for owner administration can be a technical and economic advantage for cat owners compared with oral single‑ingredient options when compliance and stress reduction are priorities.

4.4
★★★★☆

  • Spot-on simplicity

  • Pill-free

  • Spot-on simplicity

  • Pill-free

Review Summary

87%

"Profender topical is widely regarded as an easy, effective single‑application option for feline intestinal parasites, with strong efficacy and convenience—minor local irritation or transient GI signs are infrequent complaints."

  • Fur-friendly

  • Spot-on contains emodepside and praziquantel for systemic treatment of intestinal worms in cats

  • Fur-friendly

  • Spot-on contains emodepside and praziquantel for systemic treatment of intestinal worms in cats

Increased Safety & Security

Time-Saving Convenience

Profender is a topical emodepside‑praziquantel formulation that excels for feline patients that resist oral dosing, providing effective intestinal parasite control with minimal handling and a favorable safety profile. Although not a single‑ingredient product, Profender's route of administration and reduced need for owner administration can be a technical and economic advantage for cat owners compared with oral single‑ingredient options when compliance and stress reduction are priorities.

  • Spot-on simplicity

  • Pill-free

  • Fur-friendly

  • Spot-on contains emodepside and praziquantel for systemic treatment of intestinal worms in cats

  • Topical application avoids oral dosing, useful for difficult-to-pill cats

  • Spot-on simplicity

  • Pill-free

  • Fur-friendly

  • Spot-on contains emodepside and praziquantel for systemic treatment of intestinal worms in cats

  • Topical application avoids oral dosing, useful for difficult-to-pill cats

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$30-90 CAD

5
BEST SINGLE-INGREDIENT PYRANTEL SUSPENSION

Strongid T Oral Suspension

Strongid T Oral Suspension

Strongid-T (pyrantel pamoate) is a cost‑effective, single‑ingredient tetrahydropyrimidine available as an oral suspension ideal for precise dosing in small or juvenile animals and for targeted therapy of intestinal nematodes. Versus the combination tablets and topical products on this list, Strongid delivers the focused, low‑cost intervention sought in single‑ingredient protocols, though it has a narrower spectrum and may require follow‑up or complementary therapy for tapeworms or other non‑nematode parasites.

4
★★★★☆

  • Liquid dosing

  • Palatable syrup

  • Liquid dosing

  • Palatable syrup

Review Summary

81%

"Strongid T (pyrantel) oral suspension is regularly described as an inexpensive, effective treatment for roundworms and hookworms with straightforward dosing, though taste and dosing precision can be minor drawbacks on repeat use."

  • Single-ingredient hero

  • Contains pyrantel pamoate as the sole active ingredient effective against roundworms and hookworms

  • Single-ingredient hero

  • Contains pyrantel pamoate as the sole active ingredient effective against roundworms and hookworms

Increased Safety & Security

Time-Saving Convenience

Strongid-T (pyrantel pamoate) is a cost‑effective, single‑ingredient tetrahydropyrimidine available as an oral suspension ideal for precise dosing in small or juvenile animals and for targeted therapy of intestinal nematodes. Versus the combination tablets and topical products on this list, Strongid delivers the focused, low‑cost intervention sought in single‑ingredient protocols, though it has a narrower spectrum and may require follow‑up or complementary therapy for tapeworms or other non‑nematode parasites.

  • Liquid dosing

  • Palatable syrup

  • Single-ingredient hero

  • Contains pyrantel pamoate as the sole active ingredient effective against roundworms and hookworms

  • Oral liquid suspension allows accurate weight-based dosing for puppies, kittens and small animals

  • Liquid dosing

  • Palatable syrup

  • Single-ingredient hero

  • Contains pyrantel pamoate as the sole active ingredient effective against roundworms and hookworms

  • Oral liquid suspension allows accurate weight-based dosing for puppies, kittens and small animals

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$18-45 CAD

What the Research Says: Simple, Evidence-Based Benefits of Monotherapy Anthelmintics

Veterinary parasitology research supports targeted use of single-active anthelmintics in many clinical scenarios. Studies and reviews in veterinary journals emphasize that when a specific parasite is identified or strongly suspected, single-ingredient drugs can provide effective, predictable clearance with fewer variables. Research also shows that understanding pharmacokinetics, safety margins, and local resistance patterns is essential to optimize outcomes and limit the development of drug resistance.

Efficacy: Peer-reviewed clinical trials and field studies repeatedly demonstrate that single active ingredients such as fenbendazole and pyrantel achieve high efficacy against their target intestinal helminths when dosed appropriately.

Safety Profile: Monotherapy simplifies assessment of adverse events and interactions; safety studies in dogs and cats establish well-characterized therapeutic windows for commonly used agents.

Resistance Management: Targeted use based on diagnostics and selective treatment is recommended by parasitology experts to slow resistance — a principle supported by surveillance studies in veterinary populations.

Pharmacokinetics and Withdrawal: Single-ingredient products have clearer pharmacokinetic data, aiding decisions for animals in production systems or breeding programs where withdrawal or residue concerns exist.

Route and Compliance: Comparative trials note differences in owner compliance and absorption between oral suspensions, tablets, granules, and topical formulations; choosing the correct formulation improves real-world effectiveness.

In the Canadian context, single-ingredient monotherapy remains a practical choice for targeted intestinal parasite control. Among the main products covered here — Panacur Granules 22.2%, Drontal Plus Flavour Tablets, Milbemax Tablets for Dogs, Profender Topical Solution for Cats, and Strongid T Oral Suspension — Panacur Granules 22.2% stands out as the most straightforward monotherapy option for many common helminth infections because of its well-documented single-active profile and broad use in clinical practice; Strongid T Oral Suspension is another reliable single-ingredient choice for specific roundworm and hookworm targets. Note that Drontal Plus, Milbemax, and Profender are widely used anthelmintic brands in Canada and may be chosen when broader-spectrum or combination therapy is indicated; always check product labels and consult your veterinarian to match the product to the parasite problem. We hope you found what you were looking for — refine or expand your search using the site search if you want dosage guides, resistance updates, or formulation comparisons.

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