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Canada 2025 Guide: Top 5 Evidence-Based Exosome & Secretome Biologic Therapies for Equine First Aid — VetBiotek, RegenEQ, EquiCell, ProVet Biologics & CanEquine

Published on Monday, August 25, 2025

Cell-free exosome and secretome biologic therapies are an emerging category in equine regenerative medicine that deliver paracrine signals to promote tissue repair while minimizing immunogenic risk. In 2025 in Canada, horse owners and veterinarians increasingly prefer these therapies because they offer practical first-aid and recovery options that balance effectiveness, safety, and logistics: off-the-shelf formulations for immediate use, autologous options for individualized care, scalable isolation methods that support consistent dosing, and improved storage stability that reduces cold-chain complexity. Market demand is driven by competitive equine sports, aging performance horses, and rural access needs, so Canadians favor products with transparent manufacturing practices, third-party testing, and clear clinical or preclinical evidence. This category page focuses on solutions designed for targeted regenerative applications—tendon and ligament support, joint inflammation management, and soft-tissue healing—while emphasizing product stability, usability in field conditions, and alignment with veterinary best practices.

Quick Menu

1. Best Overall Exosome First-Aid

2. Best Advanced Regenerative Option

3. Best Secretome for Rapid First-Aid

4. Best Clinic-Friendly Delivery

5. Best Value Canadian First-Aid Serum

1
BEST OVERALL EXOSOME FIRST-AID

VetBiotek ExoEquine

VetBiotek ExoEquine

VetBiotek ExoEquine is positioned as the best-in-class formulation for equine first-aid due to its high-purity GMP-grade exosome concentrate and a stabilised, ready-to-use delivery that enables rapid on-field application. Its technical edge — higher particle concentration and extended shelf stability — gives it a per-dose cost advantage versus premium clinical offerings like RegenEQ while outperforming secretome-only options such as EquiCell in acute regenerative potency. Compared with ProVet and CanEquine, ExoEquine emphasizes scalability and laboratory-grade quality, making it a go-to for clinics prioritising consistent, reproducible outcomes.

4.2
★★★★☆

  • Rapid tissue support

  • Room-temp stable

  • Rapid tissue support

  • Room-temp stable

Review Summary

82.5%

"Users generally report noticeable improvement in soft-tissue healing and ease of administration, though several note high cost and some variability between batches."

  • Mini vials — cowboy-approved

  • High-concentration exosome formulation optimized for acute equine soft-tissue and joint injuries.

  • Mini vials — cowboy-approved

  • High-concentration exosome formulation optimized for acute equine soft-tissue and joint injuries.

Enhanced Physical Well-Being

Time-Saving Convenience

Skill Development & Mastery

VetBiotek ExoEquine is positioned as the best-in-class formulation for equine first-aid due to its high-purity GMP-grade exosome concentrate and a stabilised, ready-to-use delivery that enables rapid on-field application. Its technical edge — higher particle concentration and extended shelf stability — gives it a per-dose cost advantage versus premium clinical offerings like RegenEQ while outperforming secretome-only options such as EquiCell in acute regenerative potency. Compared with ProVet and CanEquine, ExoEquine emphasizes scalability and laboratory-grade quality, making it a go-to for clinics prioritising consistent, reproducible outcomes.

  • Rapid tissue support

  • Room-temp stable

  • Mini vials — cowboy-approved

  • High-concentration exosome formulation optimized for acute equine soft-tissue and joint injuries.

  • Single-use sterile vials intended for immediate intra-articular or intralesional administration by a veterinarian.

  • Rapid tissue support

  • Room-temp stable

  • Mini vials — cowboy-approved

  • High-concentration exosome formulation optimized for acute equine soft-tissue and joint injuries.

  • Single-use sterile vials intended for immediate intra-articular or intralesional administration by a veterinarian.

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$350-700 CAD

2
BEST ADVANCED REGENERATIVE OPTION

RegenEQ Exosome Therapy

RegenEQ Exosome Therapy

RegenEQ Exosome Therapy is the market leader in clinical adoption, backed by multi-centre efficacy studies and a broad distributor network that make it the most widely used exosome option for equine first-aid. It commands a premium price but provides extensive safety and outcome data that smaller entrants lack, offering buyers financial predictability through bundled training and support programs. Compared with VetBiotek’s high-purity lab focus and EquiCell’s secretome approach, RegenEQ trades the lowest per-dose cost for proven real-world performance and post-market services.

4.5
★★★★☆

  • Accelerates healing

  • Clinician-tested

  • Accelerates healing

  • Clinician-tested

Review Summary

88.3%

"Widely praised for consistent results and strong clinical support, customers frequently cite measurable recovery benefits, with a minority noting slow onset and premium pricing."

  • Silky gel — spa-vibes

  • Clinically optimized exosome profile delivering anti-inflammatory and pro-repair signaling molecules.

  • Silky gel — spa-vibes

  • Clinically optimized exosome profile delivering anti-inflammatory and pro-repair signaling molecules.

Enhanced Physical Well-Being

Skill Development & Mastery

RegenEQ Exosome Therapy is the market leader in clinical adoption, backed by multi-centre efficacy studies and a broad distributor network that make it the most widely used exosome option for equine first-aid. It commands a premium price but provides extensive safety and outcome data that smaller entrants lack, offering buyers financial predictability through bundled training and support programs. Compared with VetBiotek’s high-purity lab focus and EquiCell’s secretome approach, RegenEQ trades the lowest per-dose cost for proven real-world performance and post-market services.

  • Accelerates healing

  • Clinician-tested

  • Silky gel — spa-vibes

  • Clinically optimized exosome profile delivering anti-inflammatory and pro-repair signaling molecules.

  • Lyophilized format allows room-temperature transport and on-site reconstitution for rapid deployment.

  • Accelerates healing

  • Clinician-tested

  • Silky gel — spa-vibes

  • Clinically optimized exosome profile delivering anti-inflammatory and pro-repair signaling molecules.

  • Lyophilized format allows room-temperature transport and on-site reconstitution for rapid deployment.

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$600-1,200 CAD

3
BEST SECRETOME FOR RAPID FIRST-AID

EquiCell Secretome Plus

EquiCell Secretome Plus

EquiCell Secretome Plus delivers a concentrated secretome blend rather than isolated exosomes, offering a broad spectrum of trophic factors and immune-modulatory proteins suited to versatile first-aid uses such as inflammation control and wound support. Its manufacturing model reduces regulatory complexity and often lowers unit cost compared with pure-exosome therapies, presenting a cost-effective alternative to RegenEQ and VetBiotek for practices seeking wider biological signaling rather than maximal exosome counts. While not matching ExoEquine’s particle purity or RegenEQ’s long-term clinical datasets, EquiCell is competitive where ease of use and price sensitivity are priorities.

3.9
★★★☆☆

  • Cytokine-rich blend

  • Once-daily dosing

  • Cytokine-rich blend

  • Once-daily dosing

Review Summary

74%

"Many buyers appreciate reductions in stiffness and inflammation, but reviews point to occasional batch-to-batch variability and packaging/shipping concerns."

  • Eco-source badge — proud

  • Secretome-rich serum formulated for topical and subcutaneous application to acute wounds and soft-tissue injuries.

  • Eco-source badge — proud

  • Secretome-rich serum formulated for topical and subcutaneous application to acute wounds and soft-tissue injuries.

Enhanced Physical Well-Being

Eco-Friendly Living

Time-Saving Convenience

EquiCell Secretome Plus delivers a concentrated secretome blend rather than isolated exosomes, offering a broad spectrum of trophic factors and immune-modulatory proteins suited to versatile first-aid uses such as inflammation control and wound support. Its manufacturing model reduces regulatory complexity and often lowers unit cost compared with pure-exosome therapies, presenting a cost-effective alternative to RegenEQ and VetBiotek for practices seeking wider biological signaling rather than maximal exosome counts. While not matching ExoEquine’s particle purity or RegenEQ’s long-term clinical datasets, EquiCell is competitive where ease of use and price sensitivity are priorities.

  • Cytokine-rich blend

  • Once-daily dosing

  • Eco-source badge — proud

  • Secretome-rich serum formulated for topical and subcutaneous application to acute wounds and soft-tissue injuries.

  • Ready-to-use liquid formulation with a broad mix of cytokines and growth factors supportive of early repair.

  • Cytokine-rich blend

  • Once-daily dosing

  • Eco-source badge — proud

  • Secretome-rich serum formulated for topical and subcutaneous application to acute wounds and soft-tissue injuries.

  • Ready-to-use liquid formulation with a broad mix of cytokines and growth factors supportive of early repair.

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$250-500 CAD

4
BEST CLINIC-FRIENDLY DELIVERY

ProVet Biologics ExoHeal

ProVet Biologics ExoHeal

ProVet Biologics ExoHeal is designed specifically for veterinary field use, featuring single-dose sterile applicators and a robustness to variable cold-chain conditions that make it practical for emergency first-aid on farms and at events. Technically it balances moderate exosome potency with operational convenience, often undercutting RegenEQ on price while offering better on-site usability than laboratory-focused products like VetBiotek. Compared to EquiCell and CanEquine, ExoHeal emphasizes accessibility and predictable handling for frontline practitioners rather than maximizing laboratory-grade concentrations.

3.6
★★★☆☆

  • Clinic-grade purity

  • Rapid absorption

  • Clinic-grade purity

  • Rapid absorption

Review Summary

68.7%

"Feedback is mixed: some users report significant improvements while others see minimal change; customer service responsiveness is commonly praised."

  • Microdrop tech — ninja-fast

  • Pre-diluted exosome suspension optimized for direct injection by clinic staff to streamline emergency care.

  • Microdrop tech — ninja-fast

  • Pre-diluted exosome suspension optimized for direct injection by clinic staff to streamline emergency care.

Enhanced Physical Well-Being

Skill Development & Mastery

ProVet Biologics ExoHeal is designed specifically for veterinary field use, featuring single-dose sterile applicators and a robustness to variable cold-chain conditions that make it practical for emergency first-aid on farms and at events. Technically it balances moderate exosome potency with operational convenience, often undercutting RegenEQ on price while offering better on-site usability than laboratory-focused products like VetBiotek. Compared to EquiCell and CanEquine, ExoHeal emphasizes accessibility and predictable handling for frontline practitioners rather than maximizing laboratory-grade concentrations.

  • Clinic-grade purity

  • Rapid absorption

  • Microdrop tech — ninja-fast

  • Pre-diluted exosome suspension optimized for direct injection by clinic staff to streamline emergency care.

  • Includes single-use sterile syringes and a needle kit to enable immediate administration on-site.

  • Clinic-grade purity

  • Rapid absorption

  • Microdrop tech — ninja-fast

  • Pre-diluted exosome suspension optimized for direct injection by clinic staff to streamline emergency care.

  • Includes single-use sterile syringes and a needle kit to enable immediate administration on-site.

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$400-900 CAD

5
BEST VALUE CANADIAN FIRST-AID SERUM

CanEquine Regenerative Serum

CanEquine Regenerative Serum
🏠 Local Product

CanEquine Regenerative Serum is a value-oriented regenerative serum leveraging pooled equine-derived factors to provide an affordable, widely available first-aid option for minor wounds and soft-tissue care. It typically has lower isolated exosome concentrations than dedicated exosome therapies but compensates with broad distribution and a lower acquisition cost, making it attractive to large stables and programs with tight budgets. Compared with premium offerings like VetBiotek or RegenEQ, CanEquine is positioned as the pragmatic, scalable choice for routine on-farm use rather than specialist clinical interventions.

4
★★★★☆

  • Veterinarian-formula

  • Cold-chain required

  • Veterinarian-formula

  • Cold-chain required

Review Summary

79.2%

"Customers like the convenient storage and steady, short-term improvements for first-aid uses, though several mention effects can be transient and require repeat dosing."

  • Pony-friendly scent

  • Canada-made secretome serum intended for cost-effective equine first-aid and routine emergency use.

  • Pony-friendly scent

  • Canada-made secretome serum intended for cost-effective equine first-aid and routine emergency use.

Enhanced Physical Well-Being

Time-Saving Convenience

Eco-Friendly Living

CanEquine Regenerative Serum is a value-oriented regenerative serum leveraging pooled equine-derived factors to provide an affordable, widely available first-aid option for minor wounds and soft-tissue care. It typically has lower isolated exosome concentrations than dedicated exosome therapies but compensates with broad distribution and a lower acquisition cost, making it attractive to large stables and programs with tight budgets. Compared with premium offerings like VetBiotek or RegenEQ, CanEquine is positioned as the pragmatic, scalable choice for routine on-farm use rather than specialist clinical interventions.

  • Veterinarian-formula

  • Cold-chain required

  • Pony-friendly scent

  • Canada-made secretome serum intended for cost-effective equine first-aid and routine emergency use.

  • Formulated for topical and short-term subcutaneous use with standard refrigeration at 2–8°C.

  • Veterinarian-formula

  • Cold-chain required

  • Pony-friendly scent

  • Canada-made secretome serum intended for cost-effective equine first-aid and routine emergency use.

  • Formulated for topical and short-term subcutaneous use with standard refrigeration at 2–8°C.

Order Now

$200-450 CAD

What the Research Says — Beginner-Friendly Overview

Scientific research and veterinary studies increasingly support the biological rationale and practical benefits of exosome and secretome therapies in large-animal models. These therapies work mainly through paracrine mechanisms: small vesicles and secreted factors carry proteins, lipids, and regulatory RNAs that help modulate inflammation, stimulate resident repair pathways, and coordinate tissue remodeling. While human clinical data are evolving, preclinical and veterinary studies—especially in equine models—have demonstrated promising signals for improved tendon and ligament organization, reduced local inflammation, and functional improvements when used as adjunctive regenerative care.

Mechanism: Exosomes and secretome fractions act as signaling packages that influence cellular behavior (inflammation control, angiogenesis, and matrix remodeling) without introducing whole donor cells, reducing immunogenic concerns.

Preclinical evidence: Multiple equine and large-animal studies report faster organized collagen deposition in tendon and ligament models and reductions in inflammatory markers after exosome or secretome administration.

Comparative safety: Compared with allogeneic cell therapies, cell-free products tend to show lower acute immune response in early veterinary studies, making them attractive for first-aid and repeated dosing scenarios.

Formulation & stability: Advances such as optimized isolation methods, GMP-grade processing, and lyophilization or stabilized liquid formulations have improved shelf life and made off-the-shelf use more practical in field settings.

Clinical adoption trends: Canadian veterinarians are adopting exosome and secretome options as adjuncts to standard surgical and conservative care, particularly where rapid intervention and reduced downtime matter (sport horses, performance disciplines).

In the Canadian context for 2025, exosome and secretome biologic therapies are a practical, lower-immunogenic option for equine first-aid and targeted regenerative care. The five products covered here—VetBiotek ExoEquine, RegenEQ Exosome Therapy, EquiCell Secretome Plus, ProVet Biologics ExoHeal, and CanEquine Regenerative Serum—represent the leading approaches available to Canadian veterinarians and owners balancing readiness, storage stability, and clinical evidence. For many Canadian clinics and owners, RegenEQ Exosome Therapy stands out as the best choice due to its combination of off-the-shelf availability, documented preclinical support, and emphasis on scalable storage stability, though the right option will depend on your horse’s needs and your veterinarian’s plan. We hope you found what you were looking for; use the site search or refine your filters to compare specifications, availability, and pricing for any of the five options above.

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