Revolution Plus Subscribe & Save
Revolution Plus Subscribe & Save stands out as the broadest-spectrum monthly topical subscription, combining flea, tick and internal parasite protection with heartworm prevention in one shipment, which economically replaces multiple separate products for many households. Its financial advantage comes from reducing the need for additional prescriptions and consolidating coverage under a single auto-refill plan, making it a preferable choice for owners seeking comprehensive protection versus the primarily ectoparasite-focused spot-ons on this list.
Monthly full-coverage
Heartworm defense
Monthly full-coverage
Heartworm defense
Review Summary
"Revolution Plus gets strong reviews for broad-spectrum protection (fleas, ticks, heartworm, mites and some intestinal parasites) and the subscription convenience, with users noting excellent efficacy and low side effects in most pets. A minority report mild digestive or skin reactions, but satisfaction and perceived value are high."
Tiny-mite ninja
Monthly topical combining selamectin + sarolaner to treat/control fleas, ticks, mites and also help prevent heartworm disease.
Tiny-mite ninja
Monthly topical combining selamectin + sarolaner to treat/control fleas, ticks, mites and also help prevent heartworm disease.
Increased Safety & Security
Time-Saving Convenience
Revolution Plus Subscribe & Save stands out as the broadest-spectrum monthly topical subscription, combining flea, tick and internal parasite protection with heartworm prevention in one shipment, which economically replaces multiple separate products for many households. Its financial advantage comes from reducing the need for additional prescriptions and consolidating coverage under a single auto-refill plan, making it a preferable choice for owners seeking comprehensive protection versus the primarily ectoparasite-focused spot-ons on this list.
Monthly full-coverage
Heartworm defense
Tiny-mite ninja
Monthly topical combining selamectin + sarolaner to treat/control fleas, ticks, mites and also help prevent heartworm disease.
Veterinarian-prescribed product in many American channels and commonly available via Subscribe & Save programs.
Monthly full-coverage
Heartworm defense
Tiny-mite ninja
Monthly topical combining selamectin + sarolaner to treat/control fleas, ticks, mites and also help prevent heartworm disease.
Veterinarian-prescribed product in many American channels and commonly available via Subscribe & Save programs.
$360-600 USD
Simparica TRIO
Simparica TRIO is positioned as a best-in-class monthly chewable because it bundles flea/tick control with heartworm and intestinal parasite protection in a single, palatable dose—ideal for the "Automatic Refill Subscription Oral Chewable Preventives for Dogs" use case where simplicity matters. Compared with single-agent chewables like Bravecto and NexGard Chewables, its full-spectrum coverage can reduce the need for multiple separate products (and separate subscription line items), even if the per-dose price is higher than a flea-only product.
Triple-action — flea ninja
Heartworm-safe — tail-happy
Triple-action — flea ninja
Heartworm-safe — tail-happy
Review Summary
"Most owners report fast, reliable monthly protection against fleas, ticks, heartworms and intestinal parasites with excellent palatability and convenient refill/subscription options. A small minority report mild gastrointestinal or rare neurological side effects."
Subscription-ready — forgetful-proof
Monthly chewable combining flea and tick control with heartworm and intestinal parasite prevention.
Subscription-ready — forgetful-proof
Monthly chewable combining flea and tick control with heartworm and intestinal parasite prevention.
Increased Safety & Security
Time-Saving Convenience
Simparica TRIO is positioned as a best-in-class monthly chewable because it bundles flea/tick control with heartworm and intestinal parasite protection in a single, palatable dose—ideal for the "Automatic Refill Subscription Oral Chewable Preventives for Dogs" use case where simplicity matters. Compared with single-agent chewables like Bravecto and NexGard Chewables, its full-spectrum coverage can reduce the need for multiple separate products (and separate subscription line items), even if the per-dose price is higher than a flea-only product.
Triple-action — flea ninja
Heartworm-safe — tail-happy
Subscription-ready — forgetful-proof
Monthly chewable combining flea and tick control with heartworm and intestinal parasite prevention.
Contains sarolaner, moxidectin and pyrantel for wide parasite coverage and fast flea kill.
Triple-action — flea ninja
Heartworm-safe — tail-happy
Subscription-ready — forgetful-proof
Monthly chewable combining flea and tick control with heartworm and intestinal parasite prevention.
Contains sarolaner, moxidectin and pyrantel for wide parasite coverage and fast flea kill.
$300-500 USD
Zodiac Flea and Tick Collar for Dogs
Zodiac is recognized as a practical, widely distributed option that appeals to owners wanting straightforward protection and easy replaceability under an automatic refill model, often at a competitive price point. While it typically lacks the extended-duration chemistry of premium collars, Zodiac’s availability and lower per-unit cost make it attractive for users who prefer frequent replacements or trialing different collars via subscription.
Broad-spectrum hero
Splash-proof buddy
Broad-spectrum hero
Splash-proof buddy
Review Summary
"Zodiac collars receive generally favorable marks for flea and tick control and value, but some users experience inconsistent results and sometimes combine with other treatments."
Fast-action zap
Offers multi-month flea and tick protection at a mid-range price point.
Fast-action zap
Offers multi-month flea and tick protection at a mid-range price point.
Increased Safety & Security
Time-Saving Convenience
Zodiac is recognized as a practical, widely distributed option that appeals to owners wanting straightforward protection and easy replaceability under an automatic refill model, often at a competitive price point. While it typically lacks the extended-duration chemistry of premium collars, Zodiac’s availability and lower per-unit cost make it attractive for users who prefer frequent replacements or trialing different collars via subscription.
Broad-spectrum hero
Splash-proof buddy
Fast-action zap
Offers multi-month flea and tick protection at a mid-range price point.
Adjustable, water-resistant collar designed for active dogs.
Broad-spectrum hero
Splash-proof buddy
Fast-action zap
Offers multi-month flea and tick protection at a mid-range price point.
Adjustable, water-resistant collar designed for active dogs.
$20-40 USD
Revolution Plus Monthly Refill
Revolution Plus's monthly refill program is a top choice for owners seeking a topical, prescription-strength preventive with broad parasite coverage and the familiarity of a monthly schedule that pairs well with routine vet visits. Compared with oral chews, its topical route can be preferable for dogs that don’t reliably take pills, and subscription plans typically include reminders and steady pricing that help keep annual prevention costs predictable against competitors like Simparica Trio or NexGard Spectra.
Monthly guardian
Refill-on-repeat
Monthly guardian
Refill-on-repeat
Review Summary
"Reviewers like the broad topical protection (fleas, ticks, mites, some worms) and the steady monthly refill schedule that helps maintain adherence; a subset report local skin irritation or inconsistent absorption. Overall feedback emphasizes effectiveness with occasional tolerability issues."
Waterproof wink
Monthly topical that covers fleas, ticks, heartworm prevention and common intestinal parasites under prescription.
Waterproof wink
Monthly topical that covers fleas, ticks, heartworm prevention and common intestinal parasites under prescription.
Increased Safety & Security
Revolution Plus's monthly refill program is a top choice for owners seeking a topical, prescription-strength preventive with broad parasite coverage and the familiarity of a monthly schedule that pairs well with routine vet visits. Compared with oral chews, its topical route can be preferable for dogs that don’t reliably take pills, and subscription plans typically include reminders and steady pricing that help keep annual prevention costs predictable against competitors like Simparica Trio or NexGard Spectra.
Monthly guardian
Refill-on-repeat
Waterproof wink
Monthly topical that covers fleas, ticks, heartworm prevention and common intestinal parasites under prescription.
Subscription refills and automatic renewals simplify monthly dosing and ensure uninterrupted protection.
Monthly guardian
Refill-on-repeat
Waterproof wink
Monthly topical that covers fleas, ticks, heartworm prevention and common intestinal parasites under prescription.
Subscription refills and automatic renewals simplify monthly dosing and ensure uninterrupted protection.
$420-720 USD
Simparica Trio Auto-Ship Program
Simparica Trio's auto-ship program stands out for combining sarolaner, moxidectin and pyrantel in a single monthly chewable that covers fleas, ticks, heartworms and common intestinal worms across size and life-stage bands, making it a convenient all-in-one for multi-parasite control. Its subscription is optimized for predictable monthly dosing and veterinary oversight, offering owners a balance of comprehensive coverage and steady refill cadence versus longer-interval products and topical alternatives on this list.
Triple-action chew — tasty
Auto-ship reminders — hassle-free
Triple-action chew — tasty
Auto-ship reminders — hassle-free
Review Summary
"Users consistently praise Simparica Trio for reliably preventing fleas, ticks, and intestinal parasites with the convenience of monthly auto-ship; a minority report mild GI upset or transient lethargy after doses. Overall owners appreciate its broad protection and ease of subscription management."
Life-stage sizes — grows with pup
Monthly chewable combining flea, tick, heartworm and intestinal worm protection in one dose.
Life-stage sizes — grows with pup
Monthly chewable combining flea, tick, heartworm and intestinal worm protection in one dose.
Increased Safety & Security
Time-Saving Convenience
Simparica Trio's auto-ship program stands out for combining sarolaner, moxidectin and pyrantel in a single monthly chewable that covers fleas, ticks, heartworms and common intestinal worms across size and life-stage bands, making it a convenient all-in-one for multi-parasite control. Its subscription is optimized for predictable monthly dosing and veterinary oversight, offering owners a balance of comprehensive coverage and steady refill cadence versus longer-interval products and topical alternatives on this list.
Triple-action chew — tasty
Auto-ship reminders — hassle-free
Life-stage sizes — grows with pup
Monthly chewable combining flea, tick, heartworm and intestinal worm protection in one dose.
Available in multiple strengths to match dog size and common life stages (puppy to adult).
Triple-action chew — tasty
Auto-ship reminders — hassle-free
Life-stage sizes — grows with pup
Monthly chewable combining flea, tick, heartworm and intestinal worm protection in one dose.
Available in multiple strengths to match dog size and common life stages (puppy to adult).
$200-420 USD