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Top 5 Vet-Recommended Antimicrobial Ophthalmic Drops for Dogs in Canada (2025): Polysporin, Vetericyn, I-Drop Vet, Optixcare Wipes & Remend. Find Which One Is Right for Your Dog

Published on Thursday, August 21, 2025

Broad-spectrum antibacterial and antiviral ophthalmic products for dogs are formulated to treat bacterial and viral eye infections and to support healing of corneal ulcers, conjunctivitis, and other infectious ocular conditions. In Canada these products include topical antibiotics, antiseptics and combination preparations that are used after clinical assessment and, when indicated, culture and sensitivity testing. Consumer demand in the Canadian market is driven by growing pet ownership, a preference for veterinarian-recommended and evidence-based solutions, greater interest in at-home treatments that are safe and easy to apply, and a desire for preservative-free or low-irritant formulas for sensitive eyes. Shoppers also look for clear labeling on prescription status, multi-format options (drops, gels, wipes and lubricants), and products backed by clinical use or positive veterinary feedback.

Quick Menu

1. Best Budget Antibacterial

2. Best Non-Antibiotic Antimicrobial Gel

3. Best Veterinary Tear Substitute

4. Best Pre-Cleaning Wipes

5. Best Soothing Lubricant Drops

1
BEST BUDGET ANTIBACTERIAL

Polysporin Eye Drops for Dogs

Polysporin Eye Drops for Dogs
🏠 Local Product

Polysporin Eye Drops for Dogs is presented as a best-in-class topical antibiotic option that leverages a long-established topical brand to provide broad-spectrum bacterial coverage in an OTC, easy-to-administer drop format. Compared with the other items on this list it offers a lower-cost, familiar antibiotic approach for acute bacterial concerns, though it is more antibiotic-focused than non-antibiotic antiseptics like Vetericyn and less specialized for lubrication than products such as I-Drop Vet Plus or Remend.

4.1
★★★★☆
  • Broad-spectrum protection

  • Rapid irritation relief

  • Broad-spectrum protection

  • Rapid irritation relief

Review Summary

82%

"Users generally find Polysporin eye drops effective and affordable for minor eye irritations and superficial infections, with many reporting quick improvement. Reviewers caution it is not a substitute for veterinary diagnosis for serious or persistent problems."

  • Dog-approved formula

  • OTC topical antibiotic formulation for minor superficial bacterial eye infections.

  • Dog-approved formula

  • OTC topical antibiotic formulation for minor superficial bacterial eye infections.

Increased Safety & Security

Time-Saving Convenience

Polysporin Eye Drops for Dogs is presented as a best-in-class topical antibiotic option that leverages a long-established topical brand to provide broad-spectrum bacterial coverage in an OTC, easy-to-administer drop format. Compared with the other items on this list it offers a lower-cost, familiar antibiotic approach for acute bacterial concerns, though it is more antibiotic-focused than non-antibiotic antiseptics like Vetericyn and less specialized for lubrication than products such as I-Drop Vet Plus or Remend.

  • Broad-spectrum protection

  • Rapid irritation relief

  • Dog-approved formula

  • OTC topical antibiotic formulation for minor superficial bacterial eye infections.

  • Small tube delivers targeted application for localized canine ocular issues.

  • Broad-spectrum protection

  • Rapid irritation relief

  • Dog-approved formula

  • OTC topical antibiotic formulation for minor superficial bacterial eye infections.

  • Small tube delivers targeted application for localized canine ocular issues.

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$10-20 CAD

2
BEST NON-ANTIBIOTIC ANTIMICROBIAL GEL

Vetericyn Plus Antimicrobial Ophthalmic Gel

Generic

Vetericyn Plus Antimicrobial Ophthalmic Gel is a market-leading non-antibiotic antiseptic gel designed to reduce microbial load while being gentle on ocular tissues, giving it a technical advantage for contaminated wounds or when avoiding traditional antibiotics. Compared with Polysporin's antibiotic strategy this gel emphasizes a broad-spectrum, non-antibiotic mechanism and longer ocular contact time, and while typically pricier, it serves as a versatile first-line antiseptic that pairs well with rinsing or lubricating drops like I-Drop Vet Plus or Remend.

4.2
★★★★☆
  • Long-lasting barrier

  • Soothing non-sting

  • Long-lasting barrier

  • Soothing non-sting

Review Summary

78%

"Vetericyn Plus Ophthalmic Gel is praised for being gentle, safe around the eye, and helpful in promoting healing of mild wounds and irritation. Opinions vary for severe infections—some users saw good results while others needed additional veterinary treatment."

  • Pup-comfort gel

  • Hypochlorous-based antimicrobial gel that helps reduce microbial load without traditional antibiotics.

  • Pup-comfort gel

  • Hypochlorous-based antimicrobial gel that helps reduce microbial load without traditional antibiotics.

Increased Safety & Security

Time-Saving Convenience

Vetericyn Plus Antimicrobial Ophthalmic Gel is a market-leading non-antibiotic antiseptic gel designed to reduce microbial load while being gentle on ocular tissues, giving it a technical advantage for contaminated wounds or when avoiding traditional antibiotics. Compared with Polysporin's antibiotic strategy this gel emphasizes a broad-spectrum, non-antibiotic mechanism and longer ocular contact time, and while typically pricier, it serves as a versatile first-line antiseptic that pairs well with rinsing or lubricating drops like I-Drop Vet Plus or Remend.

  • Long-lasting barrier

  • Soothing non-sting

  • Pup-comfort gel

  • Hypochlorous-based antimicrobial gel that helps reduce microbial load without traditional antibiotics.

  • Thicker gel consistency provides longer contact time on the ocular surface.

  • Long-lasting barrier

  • Soothing non-sting

  • Pup-comfort gel

  • Hypochlorous-based antimicrobial gel that helps reduce microbial load without traditional antibiotics.

  • Thicker gel consistency provides longer contact time on the ocular surface.

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From 14.99$
3
BEST VETERINARY TEAR SUBSTITUTE

I-Drop Vet Plus

I-DROP
🏠 Local Product

I-Drop Vet Plus positions itself as a veterinary-grade ophthalmic lubricant with a formulation optimized for post-operative care and chronic corneal surface support, offering preservative-conscious packaging that reduces irritation risk with repeated dosing. Technically it fills the niche between antimicrobial agents and simple cleansers: less antibiotic-centric than Polysporin and less antiseptic than Vetericyn, while generally being more advanced (and often costlier) than basic lubricants or wipes, making it attractive for clinicians managing long-term ocular surface disease.

4.6
★★★★☆
  • Preservative-free gentle

  • Long-lasting lubrication

  • Preservative-free gentle

  • Long-lasting lubrication

Review Summary

90%

"I-Drop Vet Plus is widely recommended for its long-lasting lubrication and relief for chronic dry eye conditions; many owners report significant improvement in comfort. It is viewed as effective and vet-preferred, though some note it is pricier than basic lubricants."

  • Vet-grade calm

  • Preservative-free lubricating drops that replace and stabilize the tear film.

  • Vet-grade calm

  • Preservative-free lubricating drops that replace and stabilize the tear film.

Increased Safety & Security

Time-Saving Convenience

I-Drop Vet Plus positions itself as a veterinary-grade ophthalmic lubricant with a formulation optimized for post-operative care and chronic corneal surface support, offering preservative-conscious packaging that reduces irritation risk with repeated dosing. Technically it fills the niche between antimicrobial agents and simple cleansers: less antibiotic-centric than Polysporin and less antiseptic than Vetericyn, while generally being more advanced (and often costlier) than basic lubricants or wipes, making it attractive for clinicians managing long-term ocular surface disease.

  • Preservative-free gentle

  • Long-lasting lubrication

  • Vet-grade calm

  • Preservative-free lubricating drops that replace and stabilize the tear film.

  • Provides long-lasting moisture for dry eye, post-operative care, or chronic irritation.

  • Preservative-free gentle

  • Long-lasting lubrication

  • Vet-grade calm

  • Preservative-free lubricating drops that replace and stabilize the tear film.

  • Provides long-lasting moisture for dry eye, post-operative care, or chronic irritation.

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From 28.07$
4
BEST PRE-CLEANING WIPES

Optixcare Eye Cleaning Wipes

Opticare

Optixcare Eye Cleaning Wipes are a complementary, low-cost ocular hygiene product intended to remove discharge and debris before applying drops or gels, offering quick, practical cleaning rather than direct antimicrobial therapy. In comparison to the drops and gels on this list, these wipes are less of a treatment modality and more of a preparatory or maintenance tool — they are cheaper and easier to use than topical medicated products, but they do not replace antimicrobial or lubricating drops for active infections or severe ocular disease.

4.4
★★★★☆
  • Quick debris removal

  • Pre-moistened convenience

  • Quick debris removal

  • Pre-moistened convenience

Review Summary

86%

"Optixcare eye cleaning wipes are popular for convenient, gentle removal of discharge and daily eye cleaning, with most owners appreciating the ease of use. A minority note they are less effective on heavy crusting compared with solution-and-wash methods."

  • Travel-ready wipes

  • Pre-moistened, gentle wipes for removing discharge, debris, and crusts from the eyelid margin.

  • Travel-ready wipes

  • Pre-moistened, gentle wipes for removing discharge, debris, and crusts from the eyelid margin.

Time-Saving Convenience

Increased Safety & Security

Optixcare Eye Cleaning Wipes are a complementary, low-cost ocular hygiene product intended to remove discharge and debris before applying drops or gels, offering quick, practical cleaning rather than direct antimicrobial therapy. In comparison to the drops and gels on this list, these wipes are less of a treatment modality and more of a preparatory or maintenance tool — they are cheaper and easier to use than topical medicated products, but they do not replace antimicrobial or lubricating drops for active infections or severe ocular disease.

  • Quick debris removal

  • Pre-moistened convenience

  • Travel-ready wipes

  • Pre-moistened, gentle wipes for removing discharge, debris, and crusts from the eyelid margin.

  • Alcohol-free and formulated to be safe for regular eyelid hygiene in dogs.

  • Quick debris removal

  • Pre-moistened convenience

  • Travel-ready wipes

  • Pre-moistened, gentle wipes for removing discharge, debris, and crusts from the eyelid margin.

  • Alcohol-free and formulated to be safe for regular eyelid hygiene in dogs.

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From 85.72$
5
BEST SOOTHING LUBRICANT DROPS

Remend Eye Lubricating Drops

Remend Eye Lubricating Drops

Remend Eye Lubricating Drops deliver a balance of soothing viscosity and mild preservative systems aimed at treating dry or irritated canine eyes and supporting recovery alongside antimicrobial therapy. Financially positioned as a mid-range lubricant, Remend is typically less expensive than specialized veterinary sterile vials like I-Drop Vet Plus but provides more sustained relief than simple saline or wipes; however, it does not replace targeted antimicrobial treatments such as Polysporin or Vetericyn when infection control is required.

4.3
★★★★☆
  • Restores moisture

  • Non-clouding clarity

  • Restores moisture

  • Non-clouding clarity

Review Summary

84%

"Remend eye lubricating drops are reported to provide fast relief and good temporary lubrication for dry, irritated eyes, and many owners see noticeable improvement. Some users say the effect can be short-lived and requires frequent application for chronic conditions."

  • Nap-time relief

  • Sterile lubricating drops that soothe irritation and protect the corneal surface.

  • Nap-time relief

  • Sterile lubricating drops that soothe irritation and protect the corneal surface.

Increased Safety & Security

Time-Saving Convenience

Remend Eye Lubricating Drops deliver a balance of soothing viscosity and mild preservative systems aimed at treating dry or irritated canine eyes and supporting recovery alongside antimicrobial therapy. Financially positioned as a mid-range lubricant, Remend is typically less expensive than specialized veterinary sterile vials like I-Drop Vet Plus but provides more sustained relief than simple saline or wipes; however, it does not replace targeted antimicrobial treatments such as Polysporin or Vetericyn when infection control is required.

  • Restores moisture

  • Non-clouding clarity

  • Nap-time relief

  • Sterile lubricating drops that soothe irritation and protect the corneal surface.

  • Fast-acting relief for mild redness, dryness, or minor abrasions in dogs.

  • Restores moisture

  • Non-clouding clarity

  • Nap-time relief

  • Sterile lubricating drops that soothe irritation and protect the corneal surface.

  • Fast-acting relief for mild redness, dryness, or minor abrasions in dogs.

Order Now

$15-30 CAD

What the Research and Veterinary Guidance Say

Clinical experience and published veterinary literature support the use of topical antimicrobials and antiseptics for canine ocular infections when chosen to match the likely organisms and the clinical picture. Culture and sensitivity testing improves targeted therapy, while antiseptic and non-antibiotic antimicrobial agents can be useful adjuncts or alternatives in certain cases. Lubricants and hyaluronic-acid-based drops promote epithelial healing and reduce friction during recovery. Evidence in veterinary ophthalmology includes controlled clinical studies, in vitro antimicrobial testing, and professional consensus statements from veterinary ophthalmologists.

Topical antibiotics reduce bacterial load and help resolve bacterial conjunctivitis and superficial corneal infections, particularly when therapy is guided by culture and sensitivity.

Antiseptics such as hypochlorous formulations and povidone-iodine show broad-spectrum activity in vitro and are commonly used as adjuncts for surface cleansing and infection control.

Lubricating agents (for example, hyaluronic acid or carboxymethylcellulose) support corneal epithelial healing and patient comfort, and are important alongside antimicrobial therapy in many cases.

Randomized controlled trials in canine ophthalmology are fewer than in human medicine; much clinical guidance is drawn from peer-reviewed case series, in vitro studies and veterinary ophthalmology consensus.

Overuse or incorrect use of topical antibiotics can contribute to antimicrobial resistance; veterinarians recommend culture/sensitivity for recurrent or severe infections and short, directed courses where possible.

Product compatibility, preservative profile, and application format (drop, gel, wipe) affect owner adherence and clinical outcomes—easy-to-apply formats increase proper use in home settings.

In the Canadian 2025 context, antimicrobial ophthalmic products for dogs span accessible over-the-counter options and veterinarian-prescribed treatments that together meet varied needs for infection control, cleaning and healing. On this page we compared Polysporin Eye Drops for Dogs, Vetericyn Plus Antimicrobial Ophthalmic Gel, I-Drop Vet Plus, Optixcare Eye Cleaning Wipes, and Remend Eye Lubricating Drops. For owners looking for a versatile, antimicrobial-focused home option when an antiseptic approach is appropriate, Vetericyn Plus Antimicrobial Ophthalmic Gel stands out as a practical all-around choice, though the right selection depends on your dog’s diagnosis and your veterinarian’s guidance. I hope you found what you were looking for — you can refine or expand your search using the site search to filter by prescription status, format (drops, gel, wipes), preservative-free options, or by specific conditions such as conjunctivitis or corneal ulcers.

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