Top 6 Eye Drops and Lubricating Solutions in Canada for 2025: A Clinician-Backed Guide to Preservative-Free, Long-Lasting Relief and How to Pick the Best Fit

I-Drop Vet Plus is a veterinary-focused preservative-free single-use lubricant designed specifically for animal eyes, offering a balance of viscosity to provide longer ocular surface residence without the sting of preservatives. It stands out against human-focused single-dose options by being formulated for common canine needs and generally priced competitively for clinics that buy in bulk, making it a cost-effective choice for routine lubrication compared with higher-viscosity specialty corneal products. Compared with other entries on this list, I-Drop Vet Plus emphasizes veterinary labeling and dosing convenience, which reduces administration errors in busy practices.

Puralube Vet Ointment is a traditional, petrolatum‑based ophthalmic ointment prized for very long contact time and a straightforward, durable barrier effect on the canine ocular surface. It competes on value and durability with Optixcare by offering bulk, low‑complexity packaging that tends to reduce per‑unit cost for clinics and owners while delivering similarly long‑lasting lubrication.

Pred Forte (prednisolone acetate 1%) is a market leader for severe intraocular inflammation and postoperative control in dogs because of its strong tissue penetration and established clinical profile; many veterinary ophthalmologists prefer it for intense uveitic cases. It tends to be pricier than Maxidex but can offer superior control in select cases; as with other steroids on the list it is technically contraindicated when corneal integrity is compromised, where diclofenac or ketorolac provide safer anti‑inflammatory alternatives.

I-Drop Vet Plus positions itself as a veterinary-grade ophthalmic lubricant with a formulation optimized for post-operative care and chronic corneal surface support, offering preservative-conscious packaging that reduces irritation risk with repeated dosing. Technically it fills the niche between antimicrobial agents and simple cleansers: less antibiotic-centric than Polysporin and less antiseptic than Vetericyn, while generally being more advanced (and often costlier) than basic lubricants or wipes, making it attractive for clinicians managing long-term ocular surface disease.

I-Drop Vet Plus is a veterinary-formulated, preservative-free lubricating drop designed for frequent use in dogs; its single-use vials reduce preservative-related irritation and make it a strong economical choice for chronic, high-frequency dosing. Compared with Optimmune it does not stimulate tear production but offers a safer, low-cost option for ongoing lubrication with fewer toxicity concerns than some multi-dose products.