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2025 Guide: Top 5 Vet-Recommended Long-Lasting Lubricating Gels & Ointments for Dogs in Canada — Nighttime Protection, Reduced Dosing, and How to Choose

Published on Thursday, August 21, 2025

Viscous gels and ointments designed to provide extended ocular surface protection and lubrication help dogs with severe tear deficiency, dry eye, post-operative care, or those that need overnight relief. In Canada the market has shifted toward longer-acting formulations because pet owners and veterinarians prioritize fewer daily doses, improved comfort for aging dogs, and reliable protection during sleep or when continuous tear production is compromised. These products typically use high-viscosity polymers or petrolatum blends to prolong contact time on the cornea, reducing dosing frequency and improving clinical outcomes. Consumers choose them for convenience, measurable improvement in clinical signs, and availability in both prescription and over-the-counter formats; key decision factors include viscosity, preservative status, tube size, and veterinary endorsement.

Quick Menu

1. Best Hyaluronic Acid Gel

2. Best Preservative‑Free Vet Gel

3. Best Petroleum-Based Ointment

4. Best Soothing Rewetting Drops

5. Best Overnight Relief Gel

1
BEST HYALURONIC ACID GEL

Optixcare Eye Lube Plus

Optixcare Eye Lube Plus

Optixcare Eye Lube Plus is positioned as a clinic-favorite long‑lasting ophthalmic gel for dogs thanks to its viscous, petrolatum‑based formulation that provides extended ocular surface contact. It stands out against lighter drops on this list by delivering prolonged lubrication in a single application, offering veterinary practices a cost‑effective option for routine dry‑eye management and postoperative care.

4.4
★★★★☆
  • Ultra long-lasting

  • No-sting formula

  • Ultra long-lasting

  • No-sting formula

Review Summary

88%

"Users report Optixcare Eye Lube Plus provides long-lasting, non-irritating lubrication that helps dogs with chronic dry eye; some find the tube nozzle awkward and a few note the gel can blur vision briefly after application. Overall it's praised for comfort and durability compared with standard drops."

  • Pillow-soft shield

  • Contains hyaluronic acid for long‑lasting ocular moisture and lubrication.

  • Pillow-soft shield

  • Contains hyaluronic acid for long‑lasting ocular moisture and lubrication.

Increased Safety & Security

Time-Saving Convenience

Optixcare Eye Lube Plus is positioned as a clinic-favorite long‑lasting ophthalmic gel for dogs thanks to its viscous, petrolatum‑based formulation that provides extended ocular surface contact. It stands out against lighter drops on this list by delivering prolonged lubrication in a single application, offering veterinary practices a cost‑effective option for routine dry‑eye management and postoperative care.

  • Ultra long-lasting

  • No-sting formula

  • Pillow-soft shield

  • Contains hyaluronic acid for long‑lasting ocular moisture and lubrication.

  • Preservative‑free and sterile formulation suitable for repeated use in dogs.

  • Ultra long-lasting

  • No-sting formula

  • Pillow-soft shield

  • Contains hyaluronic acid for long‑lasting ocular moisture and lubrication.

  • Preservative‑free and sterile formulation suitable for repeated use in dogs.

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$15-25 CAD

2
BEST PRESERVATIVE‑FREE VET GEL

I-Drop Vet Plus

I-Drop Vet Plus

I‑Drop Vet Plus is a preservative‑free, hyaluronic‑acid enriched lubricant designed for sensitive canine eyes, offering long retention with low irritation risk. Compared with petrolatum ointments like Puralube, it provides a more modern tear‑mimicking hydration profile and can command a premium price for its preservative‑free, vet‑focused formulation favored in specialty care.

4.3
★★★★☆
  • Vet-strength drops

  • Non-blurring wear

  • Vet-strength drops

  • Non-blurring wear

Review Summary

85%

"I-Drop Vet Plus is commonly rated as a reliable, well-tolerated veterinary lubricant that offers good retention and ease of application for dogs; a minority of users wish it had a thicker gel consistency for even longer protection. Most owners appreciate its vet-grade formulation and tolerability."

  • Gentle-touch relief

  • Viscous, veterinary‑grade gel designed to remain on the eye longer than standard drops.

  • Gentle-touch relief

  • Viscous, veterinary‑grade gel designed to remain on the eye longer than standard drops.

Increased Safety & Security

Time-Saving Convenience

I‑Drop Vet Plus is a preservative‑free, hyaluronic‑acid enriched lubricant designed for sensitive canine eyes, offering long retention with low irritation risk. Compared with petrolatum ointments like Puralube, it provides a more modern tear‑mimicking hydration profile and can command a premium price for its preservative‑free, vet‑focused formulation favored in specialty care.

  • Vet-strength drops

  • Non-blurring wear

  • Gentle-touch relief

  • Viscous, veterinary‑grade gel designed to remain on the eye longer than standard drops.

  • Preservative‑free formulation reduces irritation risk for sensitive canine eyes.

  • Vet-strength drops

  • Non-blurring wear

  • Gentle-touch relief

  • Viscous, veterinary‑grade gel designed to remain on the eye longer than standard drops.

  • Preservative‑free formulation reduces irritation risk for sensitive canine eyes.

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$12-22 CAD

3
BEST PETROLEUM-BASED OINTMENT

Puralube Vet Ointment

Puralube Vet Ointment

Puralube Vet Ointment is a traditional, petrolatum‑based ophthalmic ointment prized for very long contact time and a straightforward, durable barrier effect on the canine ocular surface. It competes on value and durability with Optixcare by offering bulk, low‑complexity packaging that tends to reduce per‑unit cost for clinics and owners while delivering similarly long‑lasting lubrication.

4.5
★★★★☆
  • Dense moisture barrier

  • Cuddle-safe greaseless

  • Dense moisture barrier

  • Cuddle-safe greaseless

Review Summary

90%

"Puralube Vet Ointment is frequently praised for its very long-lasting, protective greasiness that soothes and shields canine eyes for extended periods, though some owners dislike the heavy, oily residue and temporary vision blur. It’s often recommended when longest-lasting lubrication is the priority."

  • Multi-use tube

  • Petrolatum‑based ointment that creates a lasting protective barrier on the ocular surface.

  • Multi-use tube

  • Petrolatum‑based ointment that creates a lasting protective barrier on the ocular surface.

Increased Safety & Security

Time-Saving Convenience

Puralube Vet Ointment is a traditional, petrolatum‑based ophthalmic ointment prized for very long contact time and a straightforward, durable barrier effect on the canine ocular surface. It competes on value and durability with Optixcare by offering bulk, low‑complexity packaging that tends to reduce per‑unit cost for clinics and owners while delivering similarly long‑lasting lubrication.

  • Dense moisture barrier

  • Cuddle-safe greaseless

  • Multi-use tube

  • Petrolatum‑based ointment that creates a lasting protective barrier on the ocular surface.

  • Very long‑acting lubrication often used overnight or for severe dryness.

  • Dense moisture barrier

  • Cuddle-safe greaseless

  • Multi-use tube

  • Petrolatum‑based ointment that creates a lasting protective barrier on the ocular surface.

  • Very long‑acting lubrication often used overnight or for severe dryness.

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$8-18 CAD

4
BEST SOOTHING REWETTING DROPS

Remend Lubricating Eye Drops

Remend Lubricating Eye Drops

Remend Lubricating Eye Drops provide a gel‑like lubrication aimed at balancing comfort and clarity, making them a versatile choice for dogs that need frequent application with less visual blurring than heavy ointments. They sit between lighter drops and thick ointments on this list, offering a mid‑range price/performance tradeoff suitable for owners who want longer relief than standard tears but less greasy residue than petrolatum options.

4
★★★★☆
  • Rapid relief drops

  • Clear non-greasy

  • Rapid relief drops

  • Clear non-greasy

Review Summary

78%

"Remend Lubricating Eye Drops receive mixed-to-positive reviews: many owners find them effective and comfortable for regular use, while others report they are less durable than ointments and require more frequent reapplication. They are generally seen as a good, gentler option but not the longest-lasting."

  • Drop-and-go ease

  • Lightweight lubricating drops that provide immediate soothing relief and rewetting.

  • Drop-and-go ease

  • Lightweight lubricating drops that provide immediate soothing relief and rewetting.

Increased Safety & Security

Time-Saving Convenience

Remend Lubricating Eye Drops provide a gel‑like lubrication aimed at balancing comfort and clarity, making them a versatile choice for dogs that need frequent application with less visual blurring than heavy ointments. They sit between lighter drops and thick ointments on this list, offering a mid‑range price/performance tradeoff suitable for owners who want longer relief than standard tears but less greasy residue than petrolatum options.

  • Rapid relief drops

  • Clear non-greasy

  • Drop-and-go ease

  • Lightweight lubricating drops that provide immediate soothing relief and rewetting.

  • Suitable for frequent use during the day and for dogs that need regular comfort boosts.

  • Rapid relief drops

  • Clear non-greasy

  • Drop-and-go ease

  • Lightweight lubricating drops that provide immediate soothing relief and rewetting.

  • Suitable for frequent use during the day and for dogs that need regular comfort boosts.

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$10-20 CAD

5
BEST OVERNIGHT RELIEF GEL

Viscotears Liquid Gel

Viscotears Liquid Gel

Viscotears Liquid Gel is a polymer‑based liquid gel that delivers sustained relief through a formulation developed for extended ocular retention and consistent tear film support. Backed by a large pharmaceutical manufacturer with broad distribution, it brings strong quality control and global availability to the veterinary market, typically at a premium versus generic ointments but with reliable shelf and supply characteristics.

4.2
★★★★☆
  • Tear-like gel

  • Long-wear comfort

  • Tear-like gel

  • Long-wear comfort

Review Summary

82%

"Viscotears Liquid Gel is noted for its viscous, long-retaining formula that provides substantial relief for dogs with moderate to severe dry eye, though some users report temporary blurring and sensitivity to preservatives in certain formulations. Overall it’s considered an effective liquid-gel compromise between drops and heavy ointments."

  • Snooze-friendly hold

  • Viscous liquid gel formulation designed to increase ocular residence time for prolonged relief.

  • Snooze-friendly hold

  • Viscous liquid gel formulation designed to increase ocular residence time for prolonged relief.

Increased Safety & Security

Time-Saving Convenience

Viscotears Liquid Gel is a polymer‑based liquid gel that delivers sustained relief through a formulation developed for extended ocular retention and consistent tear film support. Backed by a large pharmaceutical manufacturer with broad distribution, it brings strong quality control and global availability to the veterinary market, typically at a premium versus generic ointments but with reliable shelf and supply characteristics.

  • Tear-like gel

  • Long-wear comfort

  • Snooze-friendly hold

  • Viscous liquid gel formulation designed to increase ocular residence time for prolonged relief.

  • Provides a thicker, longer‑lasting film than standard drops, helpful overnight or between doses.

  • Tear-like gel

  • Long-wear comfort

  • Snooze-friendly hold

  • Viscous liquid gel formulation designed to increase ocular residence time for prolonged relief.

  • Provides a thicker, longer‑lasting film than standard drops, helpful overnight or between doses.

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$15-30 CAD

What the research and veterinary guidance say

Veterinary ophthalmology and laboratory studies explain why viscous lubricants and ointments work well for long-lasting ocular protection. The benefits arise from increased residence time on the eye surface and the ability to stabilize the tear film, which research and clinical practice link to reduced corneal irritation and improved healing in dogs with tear-film deficiencies. Below is a beginner-friendly summary of the mechanisms and the evidence veterinarians use when recommending these products.

Mechanism: High-viscosity polymers (for example, carbomers or cross-linked hyaluronic acid derivatives) and petrolatum/oil blends form a protective layer that slows tear evaporation and keeps the ocular surface lubricated for longer periods.

Clinical outcomes: Multiple veterinary ophthalmology reports and clinical case series document improved corneal staining scores, reduced discomfort, and better clinical control of chronic dry eye when long-acting lubricants are used regularly.

Dosing advantage: Long-acting gels and ointments can reduce dosing frequency compared with watery drops, which helps with owner compliance and consistent protection during sleep or when frequent dosing is impractical.

Safety and tolerability: Preservative-free or low-preservative formulations are generally recommended for chronic use to lower the risk of irritation; transient blurring of vision is a common, expected side effect immediately after application.

Practical guidance: Veterinary assessment is important to determine whether a long-acting ointment is appropriate, to rule out active infection, and to select a product that balances viscosity, comfort, and ease of administration for the individual dog.

In Canada the five long-lasting ocular lubricants highlighted here — Optixcare Eye Lube Plus, I-Drop Vet Plus, Puralube Vet Ointment, Remend Lubricating Eye Drops, and Viscotears Liquid Gel — represent the range of formulations veterinarians commonly recommend for nighttime protection and severe tear deficiency. For most dog owners seeking a dependable balance of long-lasting protection and ease of use, Optixcare Eye Lube Plus stands out as the best choice on this list due to its sustained contact time and broad availability in Canadian clinics and retailers. We hope you found what you were looking for; you can refine or expand your search by specifying concern, prescription status, or price range in the search box to find the ideal product for your dog.

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