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Veterinary Prescription Anti‑Inflammatory Eye Drops for Dogs in Canada — 2025 Expert Guide to the Top 5 Options (Maxidex, Pred Forte, Diclofenac, Neo Poly Dex, Ketorolac)

Published on Thursday, August 21, 2025

Prescription-only steroidal and nonsteroidal anti-inflammatory ophthalmic solutions and suspensions are essential tools in veterinary ophthalmology to control ocular inflammation, pain, and allergic reactions in dogs. Indicated for conditions such as uveitis, keratitis, and post-operative inflammation, these products are used under veterinary supervision to balance rapid symptom relief with careful monitoring for side effects. Canadian consumers and veterinary professionals prefer these therapies for their targeted action, proven pharmacology, and availability through veterinary clinics and licensed compounding pharmacies; buying decisions are guided by the specific diagnosis, safety profile, dosing convenience, and provincial prescription rules.

Quick Menu

1. Best Short‑term Corticosteroid for Dogs

2. Best Potent Steroid for Severe Canine Inflammation

3. Best Non‑Steroidal (NSAID) Option for Dogs

4. Best Antibiotic‑Steroid Combo for Canine Cases

5. Best NSAID for Post‑Op Pain & Inflammation in Dogs

1
BEST SHORT‑TERM CORTICOSTEROID FOR DOGS

Maxidex Ophthalmic Suspension

Maxidex Ophthalmic Suspension

Maxidex (dexamethasone) is positioned as a best-in-class topical steroid for veterinary use because it delivers potent anti‑inflammatory action in a suspension formulation that many clinicians find effective for canine anterior uveitis and allergic ocular disease. Compared with Pred Forte it is often seen as a more cost‑efficient steroid option with excellent anti‑inflammatory potency, while its steroid class necessitates careful avoidance in corneal ulceration where NSAID options on this list would be safer.

4.2
★★★★☆
  • Potent steroid relief

  • Swift redness reduction

  • Potent steroid relief

  • Swift redness reduction

Review Summary

84%

"Users report rapid reduction in ocular inflammation and improved comfort with consistent use; some note temporary stinging on instillation and express caution about long-term steroid use, but most find it effective."

  • Spa-like comfort

  • Contains dexamethasone, a potent topical corticosteroid for rapid reduction of ocular inflammation.

  • Spa-like comfort

  • Contains dexamethasone, a potent topical corticosteroid for rapid reduction of ocular inflammation.

Increased Safety & Security

Time-Saving Convenience

Maxidex (dexamethasone) is positioned as a best-in-class topical steroid for veterinary use because it delivers potent anti‑inflammatory action in a suspension formulation that many clinicians find effective for canine anterior uveitis and allergic ocular disease. Compared with Pred Forte it is often seen as a more cost‑efficient steroid option with excellent anti‑inflammatory potency, while its steroid class necessitates careful avoidance in corneal ulceration where NSAID options on this list would be safer.

  • Potent steroid relief

  • Swift redness reduction

  • Spa-like comfort

  • Contains dexamethasone, a potent topical corticosteroid for rapid reduction of ocular inflammation.

  • Typically fast‑acting for acute inflammatory conditions but contraindicated with corneal ulcers or untreated infections.

  • Potent steroid relief

  • Swift redness reduction

  • Spa-like comfort

  • Contains dexamethasone, a potent topical corticosteroid for rapid reduction of ocular inflammation.

  • Typically fast‑acting for acute inflammatory conditions but contraindicated with corneal ulcers or untreated infections.

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$10-35 CAD

2
BEST POTENT STEROID FOR SEVERE CANINE INFLAMMATION

Pred Forte 1% Eye Drops

Pred Forte 1% Eye Drops

Pred Forte (prednisolone acetate 1%) is a market leader for severe intraocular inflammation and postoperative control in dogs because of its strong tissue penetration and established clinical profile; many veterinary ophthalmologists prefer it for intense uveitic cases. It tends to be pricier than Maxidex but can offer superior control in select cases; as with other steroids on the list it is technically contraindicated when corneal integrity is compromised, where diclofenac or ketorolac provide safer anti‑inflammatory alternatives.

4.3
★★★★☆
  • Strong anti-inflammatory

  • Calms ocular pain

  • Strong anti-inflammatory

  • Calms ocular pain

Review Summary

86%

"Widely praised for strong, fast anti-inflammatory effects and clear symptom relief; occasional reports of transient burning and concerns over prolonged steroid exposure, yet the majority rate it highly."

  • Vet-trusted classic

  • Prednisolone acetate 1% suspension provides strong anti‑inflammatory effects for anterior segment inflammation.

  • Vet-trusted classic

  • Prednisolone acetate 1% suspension provides strong anti‑inflammatory effects for anterior segment inflammation.

Increased Safety & Security

Time-Saving Convenience

Pred Forte (prednisolone acetate 1%) is a market leader for severe intraocular inflammation and postoperative control in dogs because of its strong tissue penetration and established clinical profile; many veterinary ophthalmologists prefer it for intense uveitic cases. It tends to be pricier than Maxidex but can offer superior control in select cases; as with other steroids on the list it is technically contraindicated when corneal integrity is compromised, where diclofenac or ketorolac provide safer anti‑inflammatory alternatives.

  • Strong anti-inflammatory

  • Calms ocular pain

  • Vet-trusted classic

  • Prednisolone acetate 1% suspension provides strong anti‑inflammatory effects for anterior segment inflammation.

  • Requires shaking before use to re‑suspend medication for consistent dosing.

  • Strong anti-inflammatory

  • Calms ocular pain

  • Vet-trusted classic

  • Prednisolone acetate 1% suspension provides strong anti‑inflammatory effects for anterior segment inflammation.

  • Requires shaking before use to re‑suspend medication for consistent dosing.

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$20-45 CAD

3
BEST NON‑STEROIDAL (NSAID) OPTION FOR DOGS

Diclofenac Sodium Ophthalmic Solution

Diclofenac Sodium Ophthalmic Solution

Diclofenac sodium ophthalmic solution is the non‑steroidal, cost‑effective choice favored when steroid use is contraindicated in dogs (for example with corneal ulcers) because it reduces inflammation and pain without the immunosuppressive risks of corticosteroids. Compared with ketorolac/Acular it is often available as lower‑cost generics with broad availability, though NSAIDs are generally less potent than steroids for severe intraocular inflammation.

3.8
★★★☆☆
  • Non-steroidal relief

  • Targets corneal pain

  • Non-steroidal relief

  • Targets corneal pain

Review Summary

72%

"Appreciated as a steroid-sparing anti-inflammatory option with fewer steroid-related risks, but users report more variable effectiveness and some initial irritation or discomfort."

  • Lens-friendly wink

  • Diclofenac is a topical NSAID that reduces prostaglandin‑mediated ocular inflammation and pain.

  • Lens-friendly wink

  • Diclofenac is a topical NSAID that reduces prostaglandin‑mediated ocular inflammation and pain.

Increased Safety & Security

Time-Saving Convenience

Diclofenac sodium ophthalmic solution is the non‑steroidal, cost‑effective choice favored when steroid use is contraindicated in dogs (for example with corneal ulcers) because it reduces inflammation and pain without the immunosuppressive risks of corticosteroids. Compared with ketorolac/Acular it is often available as lower‑cost generics with broad availability, though NSAIDs are generally less potent than steroids for severe intraocular inflammation.

  • Non-steroidal relief

  • Targets corneal pain

  • Lens-friendly wink

  • Diclofenac is a topical NSAID that reduces prostaglandin‑mediated ocular inflammation and pain.

  • Useful when steroid use is undesirable, such as with some corneal surface diseases where steroids may delay healing.

  • Non-steroidal relief

  • Targets corneal pain

  • Lens-friendly wink

  • Diclofenac is a topical NSAID that reduces prostaglandin‑mediated ocular inflammation and pain.

  • Useful when steroid use is undesirable, such as with some corneal surface diseases where steroids may delay healing.

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$35-80 CAD

4
BEST ANTIBIOTIC‑STEROID COMBO FOR CANINE CASES

Neo Poly Dex Ophthalmic Suspension

Neo Poly Dex Ophthalmic Suspension

Neo-Poly-Dex combines a topical steroid with broad‑spectrum antibiotics (neomycin and polymyxin B plus dexamethasone), offering a convenient single‑bottle solution for dogs with concurrent bacterial infection and inflammation and reducing overall prescription complexity and dispensing costs. Its financial and practical advantage over single‑agent drops is clear when both antibiotic and anti‑inflammatory therapy are required, but it is inappropriate where corneal ulceration is suspected and where targeted antibiotic selection is preferred.

4.1
★★★★☆
  • Antibiotic+steroid combo

  • Broad infection control

  • Antibiotic+steroid combo

  • Broad infection control

Review Summary

80%

"Valued for combining antibiotic and steroid action to treat inflammatory infections; reviewers report generally good results though some experience irritation and worry about antibiotic overuse."

  • Triple-threat sparkle

  • Combination of topical antibiotic (neomycin/polymyxin B) with dexamethasone treats inflammation when bacterial infection is suspected.

  • Triple-threat sparkle

  • Combination of topical antibiotic (neomycin/polymyxin B) with dexamethasone treats inflammation when bacterial infection is suspected.

Increased Safety & Security

Time-Saving Convenience

Neo-Poly-Dex combines a topical steroid with broad‑spectrum antibiotics (neomycin and polymyxin B plus dexamethasone), offering a convenient single‑bottle solution for dogs with concurrent bacterial infection and inflammation and reducing overall prescription complexity and dispensing costs. Its financial and practical advantage over single‑agent drops is clear when both antibiotic and anti‑inflammatory therapy are required, but it is inappropriate where corneal ulceration is suspected and where targeted antibiotic selection is preferred.

  • Antibiotic+steroid combo

  • Broad infection control

  • Triple-threat sparkle

  • Combination of topical antibiotic (neomycin/polymyxin B) with dexamethasone treats inflammation when bacterial infection is suspected.

  • Convenient single‑bottle therapy for inflammatory conditions with an infectious component in dogs.

  • Antibiotic+steroid combo

  • Broad infection control

  • Triple-threat sparkle

  • Combination of topical antibiotic (neomycin/polymyxin B) with dexamethasone treats inflammation when bacterial infection is suspected.

  • Convenient single‑bottle therapy for inflammatory conditions with an infectious component in dogs.

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$12-40 CAD

5
BEST NSAID FOR POST‑OP PAIN & INFLAMMATION IN DOGS

Ketorolac Tromethamine 0.5% Ophthalmic Solution

Ketorolac Tromethamine 0.5% Ophthalmic Solution (Acular)

Ketorolac (marketed as Acular) is a veterinary‑useable NSAID commonly chosen for postoperative ocular pain control and chronic inflammatory conditions in dogs because it provides effective analgesia and anti‑inflammatory effects without steroid‑related risks. Although often more expensive than some generic NSAIDs, ketorolac is favored for ocular surface comfort and as a steroid‑sparing agent—making it a practical alternative when avoiding corticosteroids is clinically indicated.

3.9
★★★☆☆
  • Rapid pain relief

  • Minimal steroid risk

  • Rapid pain relief

  • Minimal steroid risk

Review Summary

76%

"Reported to control inflammation without steroid-associated risks and be useful post-operatively, though many users note stinging on application and a slower onset compared with steroids."

  • Clear-vision boost

  • Ketorolac 0.5% provides non‑steroidal anti‑inflammatory and analgesic effects for ocular pain and post‑operative inflammation.

  • Clear-vision boost

  • Ketorolac 0.5% provides non‑steroidal anti‑inflammatory and analgesic effects for ocular pain and post‑operative inflammation.

Increased Safety & Security

Time-Saving Convenience

Ketorolac (marketed as Acular) is a veterinary‑useable NSAID commonly chosen for postoperative ocular pain control and chronic inflammatory conditions in dogs because it provides effective analgesia and anti‑inflammatory effects without steroid‑related risks. Although often more expensive than some generic NSAIDs, ketorolac is favored for ocular surface comfort and as a steroid‑sparing agent—making it a practical alternative when avoiding corticosteroids is clinically indicated.

  • Rapid pain relief

  • Minimal steroid risk

  • Clear-vision boost

  • Ketorolac 0.5% provides non‑steroidal anti‑inflammatory and analgesic effects for ocular pain and post‑operative inflammation.

  • Does not carry steroid‑related risks like delayed wound healing, making it useful in some post‑surgical canine patients.

  • Rapid pain relief

  • Minimal steroid risk

  • Clear-vision boost

  • Ketorolac 0.5% provides non‑steroidal anti‑inflammatory and analgesic effects for ocular pain and post‑operative inflammation.

  • Does not carry steroid‑related risks like delayed wound healing, making it useful in some post‑surgical canine patients.

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$25-60 CAD

What the Research Says — Simple, Evidence-Based Points

Clinical literature and veterinary practice guidelines show that corticosteroid eye drops (like prednisolone acetate) rapidly reduce intraocular inflammation, while topical nonsteroidal anti-inflammatory drugs (NSAIDs, like ketorolac or diclofenac) reduce pain and prostaglandin-mediated inflammation with different risk profiles. Evidence from veterinary ophthalmology case series and human ophthalmic trials—often used to inform veterinary practice—supports use of both drug classes when chosen appropriately and monitored closely. The following beginner-friendly points summarize the main findings and practical implications.

Corticosteroids (for example prednisolone acetate) are highly effective at suppressing intraocular inflammation but can delay corneal healing or raise intraocular pressure if used inappropriately.

Topical NSAIDs (ketorolac, diclofenac) reduce inflammatory mediators and ocular pain with a lower risk of raising intraocular pressure, but they provide weaker anti-inflammatory potency than steroids for severe uveitis.

Combination antibiotic-steroid suspensions (such as formulations like Neo Poly Dex) are useful when inflammation coexists with or risks bacterial infection, but they require diagnostic certainty and short courses to limit side effects.

Ophthalmic formulations differ in vehicle (solution vs suspension), preservative content, and dosing frequency, which affects comfort, adherence, and tolerability in dogs.

Veterinary studies emphasize the importance of baseline ophthalmic exams, corneal integrity checks, and follow-up monitoring—early detection of adverse effects improves outcomes.

Where published randomized controlled trials in dogs are limited, veterinary clinicians often rely on controlled human ophthalmic data, pharmacology, and peer-reviewed case series to guide off-label and on-label veterinary use.

In Canada in 2025, prescription-only anti-inflammatory ophthalmic products remain a key part of veterinary care for conditions like uveitis and post-operative inflammation. The main options on this page — Maxidex Ophthalmic Suspension, Pred Forte 1% Eye Drops, Diclofenac Sodium Ophthalmic Solution, Neo Poly Dex Ophthalmic Suspension, and Ketorolac Tromethamine 0.5% Ophthalmic Solution — each have specific strengths: Pred Forte 1% Eye Drops often serve as the most potent anti-inflammatory choice for severe intraocular inflammation when used under veterinary guidance, while NSAIDs like Ketorolac and Diclofenac are preferred when steroid risks must be minimized. Maxidex and Neo Poly Dex are valuable for particular inflammatory or combined infectious scenarios. We hope you found the information you were looking for; refine or expand your search using the site search to compare dosing, side effects, provincial availability, or to find guidance specific to your dog’s diagnosis.

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