Revolution Plus Subscribe & Save
Revolution Plus Subscribe & Save stands out as the broadest-spectrum monthly topical subscription, combining flea, tick and internal parasite protection with heartworm prevention in one shipment, which economically replaces multiple separate products for many households. Its financial advantage comes from reducing the need for additional prescriptions and consolidating coverage under a single auto-refill plan, making it a preferable choice for owners seeking comprehensive protection versus the primarily ectoparasite-focused spot-ons on this list.
Monthly full-coverage
Heartworm defense
Monthly full-coverage
Heartworm defense
Review Summary
"Revolution Plus gets strong reviews for broad-spectrum protection (fleas, ticks, heartworm, mites and some intestinal parasites) and the subscription convenience, with users noting excellent efficacy and low side effects in most pets. A minority report mild digestive or skin reactions, but satisfaction and perceived value are high."
Tiny-mite ninja
Monthly topical combining selamectin + sarolaner to treat/control fleas, ticks, mites and also help prevent heartworm disease.
Tiny-mite ninja
Monthly topical combining selamectin + sarolaner to treat/control fleas, ticks, mites and also help prevent heartworm disease.
Increased Safety & Security
Time-Saving Convenience
Revolution Plus Subscribe & Save stands out as the broadest-spectrum monthly topical subscription, combining flea, tick and internal parasite protection with heartworm prevention in one shipment, which economically replaces multiple separate products for many households. Its financial advantage comes from reducing the need for additional prescriptions and consolidating coverage under a single auto-refill plan, making it a preferable choice for owners seeking comprehensive protection versus the primarily ectoparasite-focused spot-ons on this list.
Monthly full-coverage
Heartworm defense
Tiny-mite ninja
Monthly topical combining selamectin + sarolaner to treat/control fleas, ticks, mites and also help prevent heartworm disease.
Veterinarian-prescribed product in many Canadian channels and commonly available via Subscribe & Save programs.
Monthly full-coverage
Heartworm defense
Tiny-mite ninja
Monthly topical combining selamectin + sarolaner to treat/control fleas, ticks, mites and also help prevent heartworm disease.
Veterinarian-prescribed product in many Canadian channels and commonly available via Subscribe & Save programs.
$360-600 CAD
Simparica TRIO is positioned as a best-in-class monthly chewable because it bundles flea/tick control with heartworm and intestinal parasite protection in a single, palatable dose—ideal for the "Automatic Refill Subscription Oral Chewable Preventives for Dogs" use case where simplicity matters. Compared with single-agent chewables like Bravecto and NexGard Chewables, its full-spectrum coverage can reduce the need for multiple separate products (and separate subscription line items), even if the per-dose price is higher than a flea-only product.
Triple-action — flea ninja
Heartworm-safe — tail-happy
Triple-action — flea ninja
Heartworm-safe — tail-happy
Review Summary
"Most owners report fast, reliable monthly protection against fleas, ticks, heartworms and intestinal parasites with excellent palatability and convenient refill/subscription options. A small minority report mild gastrointestinal or rare neurological side effects."
Subscription-ready — forgetful-proof
Monthly chewable combining flea and tick control with heartworm and intestinal parasite prevention.
Subscription-ready — forgetful-proof
Monthly chewable combining flea and tick control with heartworm and intestinal parasite prevention.
Increased Safety & Security
Time-Saving Convenience
Simparica TRIO is positioned as a best-in-class monthly chewable because it bundles flea/tick control with heartworm and intestinal parasite protection in a single, palatable dose—ideal for the "Automatic Refill Subscription Oral Chewable Preventives for Dogs" use case where simplicity matters. Compared with single-agent chewables like Bravecto and NexGard Chewables, its full-spectrum coverage can reduce the need for multiple separate products (and separate subscription line items), even if the per-dose price is higher than a flea-only product.
Triple-action — flea ninja
Heartworm-safe — tail-happy
Subscription-ready — forgetful-proof
Monthly chewable combining flea and tick control with heartworm and intestinal parasite prevention.
Contains sarolaner, moxidectin and pyrantel for wide parasite coverage and fast flea kill.
Triple-action — flea ninja
Heartworm-safe — tail-happy
Subscription-ready — forgetful-proof
Monthly chewable combining flea and tick control with heartworm and intestinal parasite prevention.
Contains sarolaner, moxidectin and pyrantel for wide parasite coverage and fast flea kill.
$300-500 CAD
Seresto Flea and Tick Collar for Dogs
Seresto is positioned as the premium, best-in-class option because its proprietary slow-release technology delivers up to eight months of continuous protection, making it the most cost-efficient choice for an automatic refill subscription by minimizing refill frequency and shipping costs. Compared with cheaper collars on this list, Seresto’s longer wear time and broad-spectrum claims offer technical advantages for owners who want set-and-forget protection and fewer subscription interruptions.
8-month magic
Slow-release sorcery
8-month magic
Slow-release sorcery
Review Summary
"Most users find Seresto highly effective at preventing fleas and ticks for the full advertised duration with easy application and minimal maintenance; a small minority report skin irritation or adverse reactions."
No-mess ninja
Provides up to 8 months continuous flea and tick protection.
No-mess ninja
Provides up to 8 months continuous flea and tick protection.
Increased Safety & Security
Time-Saving Convenience
Seresto is positioned as the premium, best-in-class option because its proprietary slow-release technology delivers up to eight months of continuous protection, making it the most cost-efficient choice for an automatic refill subscription by minimizing refill frequency and shipping costs. Compared with cheaper collars on this list, Seresto’s longer wear time and broad-spectrum claims offer technical advantages for owners who want set-and-forget protection and fewer subscription interruptions.
8-month magic
Slow-release sorcery
No-mess ninja
Provides up to 8 months continuous flea and tick protection.
Contains imidacloprid and flumethrin for broad-spectrum control.
8-month magic
Slow-release sorcery
No-mess ninja
Provides up to 8 months continuous flea and tick protection.
Contains imidacloprid and flumethrin for broad-spectrum control.
$50-90 CAD
NexGard Spectra Subscription
NexGard Spectra's subscription offering shines as a market leader for chewable, monthly broad-spectrum protection, with widespread veterinary use and a reputation for palatability and steady efficacy against fleas, ticks and intestinal worms. Financially it can be competitive with other monthly chews and subscriptions commonly include vet oversight and discounts, making it a close alternative to Simparica Trio for owners prioritizing oral dosing and frequent, predictable refills.
Broad-spectrum guard
Subscription simple
Broad-spectrum guard
Subscription simple
Review Summary
"Owners praise the broad parasite coverage and easy monthly chewable format, with auto-delivery reducing missed doses; occasional vomiting or lethargy is reported by a small number of users. Many reviewers cite consistent effectiveness against fleas and worms."
Beef-flavored boost
Monthly beef-flavored chew that protects against fleas, ticks, heartworm and several intestinal worms.
Beef-flavored boost
Monthly beef-flavored chew that protects against fleas, ticks, heartworm and several intestinal worms.
Increased Safety & Security
Time-Saving Convenience
NexGard Spectra's subscription offering shines as a market leader for chewable, monthly broad-spectrum protection, with widespread veterinary use and a reputation for palatability and steady efficacy against fleas, ticks and intestinal worms. Financially it can be competitive with other monthly chews and subscriptions commonly include vet oversight and discounts, making it a close alternative to Simparica Trio for owners prioritizing oral dosing and frequent, predictable refills.
Broad-spectrum guard
Subscription simple
Beef-flavored boost
Monthly beef-flavored chew that protects against fleas, ticks, heartworm and several intestinal worms.
Widely available as a subscription with scheduled refills and dose adjustments by weight.
Broad-spectrum guard
Subscription simple
Beef-flavored boost
Monthly beef-flavored chew that protects against fleas, ticks, heartworm and several intestinal worms.
Widely available as a subscription with scheduled refills and dose adjustments by weight.
$300-660 CAD
Simparica Trio Auto-Ship Program
Simparica Trio's auto-ship program stands out for combining sarolaner, moxidectin and pyrantel in a single monthly chewable that covers fleas, ticks, heartworms and common intestinal worms across size and life-stage bands, making it a convenient all-in-one for multi-parasite control. Its subscription is optimized for predictable monthly dosing and veterinary oversight, offering owners a balance of comprehensive coverage and steady refill cadence versus longer-interval products and topical alternatives on this list.
Triple-action chew — tasty
Auto-ship reminders — hassle-free
Triple-action chew — tasty
Auto-ship reminders — hassle-free
Review Summary
"Users consistently praise Simparica Trio for reliably preventing fleas, ticks, and intestinal parasites with the convenience of monthly auto-ship; a minority report mild GI upset or transient lethargy after doses. Overall owners appreciate its broad protection and ease of subscription management."
Life-stage sizes — grows with pup
Monthly chewable combining flea, tick, heartworm and intestinal worm protection in one dose.
Life-stage sizes — grows with pup
Monthly chewable combining flea, tick, heartworm and intestinal worm protection in one dose.
Increased Safety & Security
Time-Saving Convenience
Simparica Trio's auto-ship program stands out for combining sarolaner, moxidectin and pyrantel in a single monthly chewable that covers fleas, ticks, heartworms and common intestinal worms across size and life-stage bands, making it a convenient all-in-one for multi-parasite control. Its subscription is optimized for predictable monthly dosing and veterinary oversight, offering owners a balance of comprehensive coverage and steady refill cadence versus longer-interval products and topical alternatives on this list.
Triple-action chew — tasty
Auto-ship reminders — hassle-free
Life-stage sizes — grows with pup
Monthly chewable combining flea, tick, heartworm and intestinal worm protection in one dose.
Available in multiple strengths to match dog size and common life stages (puppy to adult).
Triple-action chew — tasty
Auto-ship reminders — hassle-free
Life-stage sizes — grows with pup
Monthly chewable combining flea, tick, heartworm and intestinal worm protection in one dose.
Available in multiple strengths to match dog size and common life stages (puppy to adult).
$200-420 CAD