Simparica TRIO
Simparica TRIO is positioned as a best-in-class monthly chewable because it bundles flea/tick control with heartworm and intestinal parasite protection in a single, palatable dose—ideal for the "Automatic Refill Subscription Oral Chewable Preventives for Dogs" use case where simplicity matters. Compared with single-agent chewables like Bravecto and NexGard Chewables, its full-spectrum coverage can reduce the need for multiple separate products (and separate subscription line items), even if the per-dose price is higher than a flea-only product.
Triple-action — flea ninja
Heartworm-safe — tail-happy
Triple-action — flea ninja
Heartworm-safe — tail-happy
Review Summary
"Most owners report fast, reliable monthly protection against fleas, ticks, heartworms and intestinal parasites with excellent palatability and convenient refill/subscription options. A small minority report mild gastrointestinal or rare neurological side effects."
Subscription-ready — forgetful-proof
Monthly chewable combining flea and tick control with heartworm and intestinal parasite prevention.
Subscription-ready — forgetful-proof
Monthly chewable combining flea and tick control with heartworm and intestinal parasite prevention.
Increased Safety & Security
Time-Saving Convenience
Simparica TRIO is positioned as a best-in-class monthly chewable because it bundles flea/tick control with heartworm and intestinal parasite protection in a single, palatable dose—ideal for the "Automatic Refill Subscription Oral Chewable Preventives for Dogs" use case where simplicity matters. Compared with single-agent chewables like Bravecto and NexGard Chewables, its full-spectrum coverage can reduce the need for multiple separate products (and separate subscription line items), even if the per-dose price is higher than a flea-only product.
Triple-action — flea ninja
Heartworm-safe — tail-happy
Subscription-ready — forgetful-proof
Monthly chewable combining flea and tick control with heartworm and intestinal parasite prevention.
Contains sarolaner, moxidectin and pyrantel for wide parasite coverage and fast flea kill.
Triple-action — flea ninja
Heartworm-safe — tail-happy
Subscription-ready — forgetful-proof
Monthly chewable combining flea and tick control with heartworm and intestinal parasite prevention.
Contains sarolaner, moxidectin and pyrantel for wide parasite coverage and fast flea kill.
$300-500 CAD
NexGard PLUS
NexGard PLUS combines afoxolaner with milbemycin oxime in a monthly chewable that pairs proven flea/tick efficacy with intestinal and heartworm parasite control, making it a market leader for owners who want consolidated protection on a subscription. Technically similar in scope to Simparica TRIO but using different actives, it often competes on price and widespread availability, which can drive lower per-dose costs and better subscription retention for vendors.
Flea+tick duo — superhero chew
Monthly pulse — tail-wagging
Flea+tick duo — superhero chew
Monthly pulse — tail-wagging
Review Summary
"Users appreciate the broad-spectrum coverage and easy-to-administer beef-flavored chews, reporting consistent flea/tick control and intestinal worm prevention. A minority note vomiting, lethargy or rare adverse events after repeated use."
Auto-refill friendly — never-miss
Monthly chewable that treats fleas and ticks while also controlling common intestinal parasites and heartworm risk.
Auto-refill friendly — never-miss
Monthly chewable that treats fleas and ticks while also controlling common intestinal parasites and heartworm risk.
Increased Safety & Security
Time-Saving Convenience
NexGard PLUS combines afoxolaner with milbemycin oxime in a monthly chewable that pairs proven flea/tick efficacy with intestinal and heartworm parasite control, making it a market leader for owners who want consolidated protection on a subscription. Technically similar in scope to Simparica TRIO but using different actives, it often competes on price and widespread availability, which can drive lower per-dose costs and better subscription retention for vendors.
Flea+tick duo — superhero chew
Monthly pulse — tail-wagging
Auto-refill friendly — never-miss
Monthly chewable that treats fleas and ticks while also controlling common intestinal parasites and heartworm risk.
Formulated with afoxolaner plus milbemycin oxime for broad-spectrum parasite protection.
Flea+tick duo — superhero chew
Monthly pulse — tail-wagging
Auto-refill friendly — never-miss
Monthly chewable that treats fleas and ticks while also controlling common intestinal parasites and heartworm risk.
Formulated with afoxolaner plus milbemycin oxime for broad-spectrum parasite protection.
$240-420 CAD
Bravecto Chews
Bravecto Chews stand out for their long-duration fluralaner formulation that provides up to 12 weeks of flea and tick protection per dose, reducing the number of refill events and shipping/billing cycles in a subscription model. Unlike the combo monthly products, Bravecto does not cover heartworm or intestinal worms, so while it lowers logistical costs and subscription churn, it usually must be paired with a separate heartworm preventive to match the protection breadth of combo chews.
12-week protection — lazy-dog dream
Fast kill — itch relief
12-week protection — lazy-dog dream
Fast kill — itch relief
Review Summary
"Many owners like the 12-week dosing interval and find it highly effective at preventing fleas and ticks, which reduces dosing hassle. Some users report seizures or other adverse reactions in rare cases and palatability can be mixed for picky dogs."
Subscription OK — calendar-free
Long-duration chewable that provides up to 12 weeks of protection against fleas and ticks per dose.
Subscription OK — calendar-free
Long-duration chewable that provides up to 12 weeks of protection against fleas and ticks per dose.
Increased Safety & Security
Time-Saving Convenience
Bravecto Chews stand out for their long-duration fluralaner formulation that provides up to 12 weeks of flea and tick protection per dose, reducing the number of refill events and shipping/billing cycles in a subscription model. Unlike the combo monthly products, Bravecto does not cover heartworm or intestinal worms, so while it lowers logistical costs and subscription churn, it usually must be paired with a separate heartworm preventive to match the protection breadth of combo chews.
12-week protection — lazy-dog dream
Fast kill — itch relief
Subscription OK — calendar-free
Long-duration chewable that provides up to 12 weeks of protection against fleas and ticks per dose.
Contains fluralaner for rapid and sustained flea and tick kill, reducing dosing frequency.
12-week protection — lazy-dog dream
Fast kill — itch relief
Subscription OK — calendar-free
Long-duration chewable that provides up to 12 weeks of protection against fleas and ticks per dose.
Contains fluralaner for rapid and sustained flea and tick kill, reducing dosing frequency.
$160-320 CAD
Credelio PLUS
Credelio PLUS offers a monthly chewable combining lotilaner with milbemycin oxime, delivering fast-acting flea and tick control alongside intestinal and heartworm protection that fits neatly into recurring refill plans. It competes directly with other combo products on technical speed of kill and often on pricing, making it an attractive option for subscription services targeting cost-conscious pet owners seeking consolidated protection.
Rapid kill — flea vanisher
Broad worm cover — tummy guard
Rapid kill — flea vanisher
Broad worm cover — tummy guard
Review Summary
"Owners report strong monthly flea and tick control with good palatability and added intestinal parasite coverage; many appreciate the straightforward dosing and subscription convenience. Long-term, large-cohort experience is still building, but reported side effects appear relatively uncommon."
Subscription-ready — pantry-perfect
Monthly chewable combining a potent ectoparasiticide with heartworm and intestinal parasite prevention.
Subscription-ready — pantry-perfect
Monthly chewable combining a potent ectoparasiticide with heartworm and intestinal parasite prevention.
Increased Safety & Security
Time-Saving Convenience
Credelio PLUS offers a monthly chewable combining lotilaner with milbemycin oxime, delivering fast-acting flea and tick control alongside intestinal and heartworm protection that fits neatly into recurring refill plans. It competes directly with other combo products on technical speed of kill and often on pricing, making it an attractive option for subscription services targeting cost-conscious pet owners seeking consolidated protection.
Rapid kill — flea vanisher
Broad worm cover — tummy guard
Subscription-ready — pantry-perfect
Monthly chewable combining a potent ectoparasiticide with heartworm and intestinal parasite prevention.
Contains lotilaner plus milbemycin oxime for effective flea, tick and worm control.
Rapid kill — flea vanisher
Broad worm cover — tummy guard
Subscription-ready — pantry-perfect
Monthly chewable combining a potent ectoparasiticide with heartworm and intestinal parasite prevention.
Contains lotilaner plus milbemycin oxime for effective flea, tick and worm control.
$220-400 CAD
NexGard Chewables
NexGard Chewables (afoxolaner) are a well-established monthly flea and tick-only chewable that often represents the lower-cost entry point for subscription buyers who prioritize ectoparasite control. While simpler and typically less expensive per month than combo products, subscribers should be aware it does not include heartworm or intestinal parasite coverage, which can increase overall program complexity and total spend if additional preventives are added to the subscription.
Powerful tick kill — backyard-proof
Beef-flavored — treat-like
Powerful tick kill — backyard-proof
Beef-flavored — treat-like
Review Summary
"Widely rated as effective and tasty for monthly flea and tick prevention, with most users seeing quick results and easy administration. A minority report vomiting, lethargy or rare neurological events after repeated doses."
Easy auto-refill — pill-free routine
Monthly chewable focused on fast and reliable flea and tick control with afoxolaner as the active ingredient.
Easy auto-refill — pill-free routine
Monthly chewable focused on fast and reliable flea and tick control with afoxolaner as the active ingredient.
Increased Safety & Security
Time-Saving Convenience
NexGard Chewables (afoxolaner) are a well-established monthly flea and tick-only chewable that often represents the lower-cost entry point for subscription buyers who prioritize ectoparasite control. While simpler and typically less expensive per month than combo products, subscribers should be aware it does not include heartworm or intestinal parasite coverage, which can increase overall program complexity and total spend if additional preventives are added to the subscription.
Powerful tick kill — backyard-proof
Beef-flavored — treat-like
Easy auto-refill — pill-free routine
Monthly chewable focused on fast and reliable flea and tick control with afoxolaner as the active ingredient.
Popular, palatable option with proven efficacy and easy monthly dosing.
Powerful tick kill — backyard-proof
Beef-flavored — treat-like
Easy auto-refill — pill-free routine
Monthly chewable focused on fast and reliable flea and tick control with afoxolaner as the active ingredient.
Popular, palatable option with proven efficacy and easy monthly dosing.
$200-380 CAD