Simparica Trio
Simparica Trio (sarolaner/moxidectin/pyrantel) is positioned as a best-in-class monthly chewable for prescription antiparasitic care because it combines flea/tick control with heartworm prevention and intestinal worm treatment in a single product, reducing the need for multiple prescriptions. Compared with single-focus competitors on this list, its technical advantage is comprehensive multi-parasite protection in one dose, which can lower overall annual cost and improve owner compliance for canine antiparasitic regimens.
Triple-action protection
Monthly chewable dose
Triple-action protection
Monthly chewable dose
Review Summary
"Users report Simparica Trio is highly effective at preventing fleas, ticks, heartworm, and common intestinal worms with a palatable chew and fast action; occasional mild GI or neurologic side effects are reported but are uncommon."
Pup-approved snack
Monthly oral chewable combining sarolaner, moxidectin and pyrantel for fleas, ticks, heartworm prevention and common intestinal worms.
Pup-approved snack
Monthly oral chewable combining sarolaner, moxidectin and pyrantel for fleas, ticks, heartworm prevention and common intestinal worms.
Increased Safety & Security
Time-Saving Convenience
Recreational Enjoyment
Simparica Trio (sarolaner/moxidectin/pyrantel) is positioned as a best-in-class monthly chewable for prescription antiparasitic care because it combines flea/tick control with heartworm prevention and intestinal worm treatment in a single product, reducing the need for multiple prescriptions. Compared with single-focus competitors on this list, its technical advantage is comprehensive multi-parasite protection in one dose, which can lower overall annual cost and improve owner compliance for canine antiparasitic regimens.
Triple-action protection
Monthly chewable dose
Pup-approved snack
Monthly oral chewable combining sarolaner, moxidectin and pyrantel for fleas, ticks, heartworm prevention and common intestinal worms.
Designed as a single prescription product to simplify year-round parasite control for most dogs.
Triple-action protection
Monthly chewable dose
Pup-approved snack
Monthly oral chewable combining sarolaner, moxidectin and pyrantel for fleas, ticks, heartworm prevention and common intestinal worms.
Designed as a single prescription product to simplify year-round parasite control for most dogs.
$200-350 CAD
Bravecto
Bravecto (fluralaner) is a market leader due to its long-acting efficacy — up to 12 weeks per dose for many flea and tick indications — offering superior dosing convenience for prescription antiparasitic care. While it does not provide heartworm or broad intestinal parasite prevention like some combination products listed here, its reduced dosing frequency can translate to better compliance and lower touchpoint costs for owners who combine it with separate internal parasite coverage.
12-week protection
Chew or topical
12-week protection
Chew or topical
Review Summary
"Bravecto is praised for its long-lasting (up to 12-week) flea and tick protection and convenience, with many owners noting strong effectiveness; a small minority report adverse reactions, including GI or neurologic events."
Quarterly freedom
Provides up to 12 weeks of flea and tick protection per dose using the active ingredient fluralaner.
Quarterly freedom
Provides up to 12 weeks of flea and tick protection per dose using the active ingredient fluralaner.
Increased Safety & Security
Time-Saving Convenience
Bravecto (fluralaner) is a market leader due to its long-acting efficacy — up to 12 weeks per dose for many flea and tick indications — offering superior dosing convenience for prescription antiparasitic care. While it does not provide heartworm or broad intestinal parasite prevention like some combination products listed here, its reduced dosing frequency can translate to better compliance and lower touchpoint costs for owners who combine it with separate internal parasite coverage.
12-week protection
Chew or topical
Quarterly freedom
Provides up to 12 weeks of flea and tick protection per dose using the active ingredient fluralaner.
Available as an oral chew or topical formulation depending on product version and dog preference.
12-week protection
Chew or topical
Quarterly freedom
Provides up to 12 weeks of flea and tick protection per dose using the active ingredient fluralaner.
Available as an oral chew or topical formulation depending on product version and dog preference.
$180-450 CAD
NexGard Spectra
NexGard Spectra (afoxolaner/milbemycin oxime) holds a strong market position as a monthly chewable that pairs robust ectoparasite control with protection against heartworm and several intestinal parasites, giving it a technical profile similar to other combos but with a different active-ingredient mix. Financially competitive against other combination products, it offers clinics and owners an alternative single-prescription option that avoids the need for separate heartworm or deworming products while matching many of the protection features of rivals.
Broad-spectrum coverage
Monthly beef chew
Broad-spectrum coverage
Monthly beef chew
Review Summary
"NexGard Spectra is frequently rated effective and easy to administer monthly for fleas, ticks, and internal parasites, with most dogs accepting the chew; some users note occasional vomiting or decreased appetite."
Parasite combo hero
Monthly chewable that combines afoxolaner and milbemycin oxime to treat fleas, ticks, heartworm prevention and common intestinal worms.
Parasite combo hero
Monthly chewable that combines afoxolaner and milbemycin oxime to treat fleas, ticks, heartworm prevention and common intestinal worms.
Increased Safety & Security
Time-Saving Convenience
NexGard Spectra (afoxolaner/milbemycin oxime) holds a strong market position as a monthly chewable that pairs robust ectoparasite control with protection against heartworm and several intestinal parasites, giving it a technical profile similar to other combos but with a different active-ingredient mix. Financially competitive against other combination products, it offers clinics and owners an alternative single-prescription option that avoids the need for separate heartworm or deworming products while matching many of the protection features of rivals.
Broad-spectrum coverage
Monthly beef chew
Parasite combo hero
Monthly chewable that combines afoxolaner and milbemycin oxime to treat fleas, ticks, heartworm prevention and common intestinal worms.
Prescription product offering convenient monthly dosing for comprehensive external and internal parasite control.
Broad-spectrum coverage
Monthly beef chew
Parasite combo hero
Monthly chewable that combines afoxolaner and milbemycin oxime to treat fleas, ticks, heartworm prevention and common intestinal worms.
Prescription product offering convenient monthly dosing for comprehensive external and internal parasite control.
$200-360 CAD
Revolution Plus
Revolution Plus (selamectin/sarolaner) is notable for bringing broad-spectrum, topical monthly protection to the prescription antiparasitic category, combining heartworm prevention with flea, tick and mite control in a non-oral formulation. Its technical advantage is being a topical alternative for dogs that resist chews or require multi-species household management, though topicals may command different pricing and administration preferences versus oral combos on this list.
Topical monthly ease
Covers mites & fleas
Topical monthly ease
Covers mites & fleas
Review Summary
"Revolution Plus topical gets solid marks for broad parasite coverage (fleas, ticks, mites, heartworm and some worms) and ease of use, though a subset of owners report local skin reactions or concerns about effectiveness on certain tick species."
Bath-friendly formula
Topical monthly treatment combining selamectin and sarolaner to control fleas, ticks, ear mites, and prevent heartworm.
Bath-friendly formula
Topical monthly treatment combining selamectin and sarolaner to control fleas, ticks, ear mites, and prevent heartworm.
Increased Safety & Security
Time-Saving Convenience
Revolution Plus (selamectin/sarolaner) is notable for bringing broad-spectrum, topical monthly protection to the prescription antiparasitic category, combining heartworm prevention with flea, tick and mite control in a non-oral formulation. Its technical advantage is being a topical alternative for dogs that resist chews or require multi-species household management, though topicals may command different pricing and administration preferences versus oral combos on this list.
Topical monthly ease
Covers mites & fleas
Bath-friendly formula
Topical monthly treatment combining selamectin and sarolaner to control fleas, ticks, ear mites, and prevent heartworm.
Useful for dogs that cannot take oral chews or where topical delivery is preferred by the veterinarian.
Topical monthly ease
Covers mites & fleas
Bath-friendly formula
Topical monthly treatment combining selamectin and sarolaner to control fleas, ticks, ear mites, and prevent heartworm.
Useful for dogs that cannot take oral chews or where topical delivery is preferred by the veterinarian.
$240-480 CAD
Interceptor Plus
Interceptor Plus (milbemycin oxime/praziquantel) is a prescription-focused choice for clinics prioritizing internal parasite control, offering dependable monthly heartworm prevention and broad-spectrum intestinal parasite (including tapeworm) treatment. Unlike the ectoparasite-covering products in this list, its technical and financial niche is targeted, cost-effective internal parasite management that is often prescribed alongside a separate flea/tick product when comprehensive protection is required.
Comprehensive worm control
Monthly palatable tablet
Comprehensive worm control
Monthly palatable tablet
Review Summary
"Interceptor Plus is generally viewed as effective for heartworm and intestinal parasite control with a familiar monthly dosing, but some owners dislike pill administration and a minority report mild side effects like vomiting or lethargy."
Tapeworm terminator
Monthly tablet (milbemycin oxime + praziquantel) focused on heartworm prevention and treatment of tapeworms and other intestinal parasites.
Tapeworm terminator
Monthly tablet (milbemycin oxime + praziquantel) focused on heartworm prevention and treatment of tapeworms and other intestinal parasites.
Increased Safety & Security
Interceptor Plus (milbemycin oxime/praziquantel) is a prescription-focused choice for clinics prioritizing internal parasite control, offering dependable monthly heartworm prevention and broad-spectrum intestinal parasite (including tapeworm) treatment. Unlike the ectoparasite-covering products in this list, its technical and financial niche is targeted, cost-effective internal parasite management that is often prescribed alongside a separate flea/tick product when comprehensive protection is required.
Comprehensive worm control
Monthly palatable tablet
Tapeworm terminator
Monthly tablet (milbemycin oxime + praziquantel) focused on heartworm prevention and treatment of tapeworms and other intestinal parasites.
Cost-effective prescription option when primary concern is internal parasites rather than fleas or ticks.
Comprehensive worm control
Monthly palatable tablet
Tapeworm terminator
Monthly tablet (milbemycin oxime + praziquantel) focused on heartworm prevention and treatment of tapeworms and other intestinal parasites.
Cost-effective prescription option when primary concern is internal parasites rather than fleas or ticks.
$120-260 CAD