Florinef Acetate 0.1mg
Florinef (fludrocortisone acetate) 0.1 mg is an oral mineralocorticoid with intrinsic glucocorticoid activity commonly used for canine adrenal replacement when owners prefer daily at‑home dosing. Compared with Percorten‑V injectable it offers combined mineralocorticoid and glucocorticoid effects without clinic visits, but typically incurs higher ongoing pill costs and relies on strict owner adherence; versus pure glucocorticoids like prednisolone and dexamethasone it uniquely provides mineralocorticoid support needed in Addisonian dogs.
Stabilizes electrolytes
Pocket-sized powerhouse
Stabilizes electrolytes
Pocket-sized powerhouse
Review Summary
"Owners report Florinef reliably controls Addisonian symptoms with steady daily dosing; some note the need for electrolyte monitoring, occasional side effects, and moderate cost."
Keeps tails wagging
Oral fludrocortisone for long-term mineralocorticoid support in hypoadrenocorticism.
Keeps tails wagging
Oral fludrocortisone for long-term mineralocorticoid support in hypoadrenocorticism.
Increased Safety & Security
Time-Saving Convenience
Florinef (fludrocortisone acetate) 0.1 mg is an oral mineralocorticoid with intrinsic glucocorticoid activity commonly used for canine adrenal replacement when owners prefer daily at‑home dosing. Compared with Percorten‑V injectable it offers combined mineralocorticoid and glucocorticoid effects without clinic visits, but typically incurs higher ongoing pill costs and relies on strict owner adherence; versus pure glucocorticoids like prednisolone and dexamethasone it uniquely provides mineralocorticoid support needed in Addisonian dogs.
Stabilizes electrolytes
Pocket-sized powerhouse
Keeps tails wagging
Oral fludrocortisone for long-term mineralocorticoid support in hypoadrenocorticism.
Low-dose 0.1 mg tablets allow precise titration for small dogs.
Stabilizes electrolytes
Pocket-sized powerhouse
Keeps tails wagging
Oral fludrocortisone for long-term mineralocorticoid support in hypoadrenocorticism.
Low-dose 0.1 mg tablets allow precise titration for small dogs.
$30-80 CAD
Percorten-V Injectable
Percorten‑V (desoxycorticosterone pivalate, DOCP) Injectable is the market‑leading long‑acting parenteral mineralocorticoid for dogs with primary hypoadrenocorticism, delivering predictable monthly electrolyte control. Its technical advantage over oral Florinef is steadier mineralocorticoid replacement with fewer compliance issues and often better long‑term cost‑effectiveness despite higher upfront injection visit charges; because it lacks glucocorticoid activity it is routinely used alongside a separate glucocorticoid such as prednisolone.
Long-acting injection
Fewer daily pills
Long-acting injection
Fewer daily pills
Review Summary
"Percorten-V is widely praised for consistent, long-lasting mineralocorticoid replacement and predictable monthly control; main complaints are expense and the necessity of veterinary-administered injections."
Bounce-back energy
Monthly injectable desoxycorticosterone pivalate for reliable mineralocorticoid replacement.
Bounce-back energy
Monthly injectable desoxycorticosterone pivalate for reliable mineralocorticoid replacement.
Increased Safety & Security
Time-Saving Convenience
Percorten‑V (desoxycorticosterone pivalate, DOCP) Injectable is the market‑leading long‑acting parenteral mineralocorticoid for dogs with primary hypoadrenocorticism, delivering predictable monthly electrolyte control. Its technical advantage over oral Florinef is steadier mineralocorticoid replacement with fewer compliance issues and often better long‑term cost‑effectiveness despite higher upfront injection visit charges; because it lacks glucocorticoid activity it is routinely used alongside a separate glucocorticoid such as prednisolone.
Long-acting injection
Fewer daily pills
Bounce-back energy
Monthly injectable desoxycorticosterone pivalate for reliable mineralocorticoid replacement.
Provides consistent electrolyte control with less frequent dosing than oral options.
Long-acting injection
Fewer daily pills
Bounce-back energy
Monthly injectable desoxycorticosterone pivalate for reliable mineralocorticoid replacement.
Provides consistent electrolyte control with less frequent dosing than oral options.
$120-250 CAD
Prednisolone 5mg Tablets
Prednisolone 5 mg tablets are the most commonly used, cost‑effective oral glucocorticoid for physiologic replacement and anti‑inflammatory or immunosuppressive indications in dogs. Widely available as an inexpensive generic, prednisolone is the practical glucocorticoid partner to mineralocorticoid agents (Percorten‑V or Florinef) for Addisonian management, and is generally preferred over dexamethasone for routine replacement because of its more physiologic potency and dosing profile.
Controls inflammation
Easy oral dosing
Controls inflammation
Easy oral dosing
Review Summary
"Prednisolone 5mg is commonly rated effective for inflammation and immune conditions, but many long-term users report side effects such as increased thirst, appetite, and weight gain."
Calm, comfy pup
Systemic glucocorticoid for anti-inflammatory and immunosuppressive therapy in dogs.
Calm, comfy pup
Systemic glucocorticoid for anti-inflammatory and immunosuppressive therapy in dogs.
Increased Safety & Security
Time-Saving Convenience
Prednisolone 5 mg tablets are the most commonly used, cost‑effective oral glucocorticoid for physiologic replacement and anti‑inflammatory or immunosuppressive indications in dogs. Widely available as an inexpensive generic, prednisolone is the practical glucocorticoid partner to mineralocorticoid agents (Percorten‑V or Florinef) for Addisonian management, and is generally preferred over dexamethasone for routine replacement because of its more physiologic potency and dosing profile.
Controls inflammation
Easy oral dosing
Calm, comfy pup
Systemic glucocorticoid for anti-inflammatory and immunosuppressive therapy in dogs.
Preferred over prednisone in patients with hepatic dysfunction because it is the active metabolite.
Controls inflammation
Easy oral dosing
Calm, comfy pup
Systemic glucocorticoid for anti-inflammatory and immunosuppressive therapy in dogs.
Preferred over prednisone in patients with hepatic dysfunction because it is the active metabolite.
$15-50 CAD
Dexamethasone 0.5mg Tablets
Dexamethasone 0.5 mg tablets provide a highly potent, long‑acting glucocorticoid useful for acute anti‑inflammatory therapy and certain diagnostic protocols where strong suppression or rapid clinical effect is required. Not appropriate for chronic physiologic replacement due to potency and duration, dexamethasone's low mineralocorticoid activity and rapid onset make it a technical choice in emergencies and specific testing situations, distinguishing it from the daily replacement role of prednisolone or the mineralocorticoids in this list.
Potent anti-inflammatory
Rapid symptom relief
Potent anti-inflammatory
Rapid symptom relief
Review Summary
"Dexamethasone 0.5mg is valued for rapid, strong anti-inflammatory effect; reviewers emphasize careful dosing due to more pronounced steroid side effects with prolonged use."
Emergency-ready boost
Potent glucocorticoid used for severe inflammation and certain diagnostic protocols.
Emergency-ready boost
Potent glucocorticoid used for severe inflammation and certain diagnostic protocols.
Increased Safety & Security
Time-Saving Convenience
Dexamethasone 0.5 mg tablets provide a highly potent, long‑acting glucocorticoid useful for acute anti‑inflammatory therapy and certain diagnostic protocols where strong suppression or rapid clinical effect is required. Not appropriate for chronic physiologic replacement due to potency and duration, dexamethasone's low mineralocorticoid activity and rapid onset make it a technical choice in emergencies and specific testing situations, distinguishing it from the daily replacement role of prednisolone or the mineralocorticoids in this list.
Potent anti-inflammatory
Rapid symptom relief
Emergency-ready boost
Potent glucocorticoid used for severe inflammation and certain diagnostic protocols.
Low-dose 0.5 mg tablets enable precise dosing for acute or short-term therapy.
Potent anti-inflammatory
Rapid symptom relief
Emergency-ready boost
Potent glucocorticoid used for severe inflammation and certain diagnostic protocols.
Low-dose 0.5 mg tablets enable precise dosing for acute or short-term therapy.
$10-40 CAD
Cortrosyn Injectable
Cortrosyn (cosyntropin) Injectable is the synthetic ACTH standard used in ACTH stimulation testing to diagnose adrenal insufficiency in dogs and is therefore central to targeted adrenal therapy. Its diagnostic precision reduces unnecessary long‑term medication costs by ensuring DOCP or fludrocortisone are prescribed only when indicated, making it an essential complement to the therapeutic agents on this list rather than a replacement.
Assesses adrenal function
Single-dose precision
Assesses adrenal function
Single-dose precision
Review Summary
"Cortrosyn injectable is considered the diagnostic standard for ACTH stimulation testing and generally performs reliably, though users frequently cite high cost, occasional supply shortages, and variable lab logistics."
Vet-approved detective
Synthetic ACTH (cosyntropin) used to perform ACTH stimulation tests to evaluate adrenal function.
Vet-approved detective
Synthetic ACTH (cosyntropin) used to perform ACTH stimulation tests to evaluate adrenal function.
Increased Safety & Security
Skill Development & Mastery
Cortrosyn (cosyntropin) Injectable is the synthetic ACTH standard used in ACTH stimulation testing to diagnose adrenal insufficiency in dogs and is therefore central to targeted adrenal therapy. Its diagnostic precision reduces unnecessary long‑term medication costs by ensuring DOCP or fludrocortisone are prescribed only when indicated, making it an essential complement to the therapeutic agents on this list rather than a replacement.
Assesses adrenal function
Single-dose precision
Vet-approved detective
Synthetic ACTH (cosyntropin) used to perform ACTH stimulation tests to evaluate adrenal function.
Typically supplied as single-use vials or kits for in-clinic diagnostic use.
Assesses adrenal function
Single-dose precision
Vet-approved detective
Synthetic ACTH (cosyntropin) used to perform ACTH stimulation tests to evaluate adrenal function.
Typically supplied as single-use vials or kits for in-clinic diagnostic use.
$250-450 CAD