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Top 5 Veterinary Prescription Ophthalmic Medications for Dogs in Canada (2025): Clinician-Verified Options to Protect Your Dog's Vision - Which Is Right for Your Pet?

Prescription eye drops, ointments, and systemic agents are essential tools for treating ocular infections, inflammation, glaucoma, and other eye disorders in dogs. This category covers clinician-prescribed topical antibiotics and antifungals, anti-inflammatories and immunomodulators (for example, cyclosporine and tacrolimus), prostaglandin analogues and beta-blockers for glaucoma management, and systemic agents used when topical therapy is insufficient. Canadian pet owners and veterinarians increasingly prefer evidence-driven, diagnostic-guided therapy that balances efficacy with safety — including preservative-free or low-preservative formulations to reduce corneal toxicity, compounded preparations when commercial products are unavailable, and clear instructions on application technique to maximize compliance. Accessibility, regulatory requirements for prescriptions in Canada, cost, and the ability to follow up with telemedicine or regional ophthalmology specialists also shape consumer preference in 2025, making a curated top-5 list valuable for quick, informed decisions.

1
BEST VETERINARY PRESCRIPTION ANTIGLAUCOMA EYE MEDICATIONS FOR DOGS

Xalatan (latanoprost) 0.005% ophthalmic solution

Xalatan (latanoprost) 0.005% ophthalmic solution

Xalatan (latanoprost) is widely regarded as a first-line topical prostaglandin analogue for acute intraocular pressure (IOP) lowering in dogs because of its rapid onset and strong IOP-reducing effect; its long history and availability as a generic translate into lower cost per dose compared with some newer branded alternatives. Compared with travoprost and bimatoprost, latanoprost often produces faster pressure drops, while it lacks the preservative-free delivery advantage of tafluprost (Zioptan) and the tolerability profile of lower-potency agents like unoprostone (Rescula).

4.5
Show More Veterinary Prescription Antiglaucoma Eye Medications for Dogs
  • Rapid IOP drop (zippy)

  • Proven track record (veteran)

  • Rapid IOP drop (zippy)

  • Proven track record (veteran)

Review Summary

88%

"Veterinarians and dog owners report rapid, reliable intraocular pressure reduction with latanoprost in dogs, though many note transient ocular irritation, miosis and gradual periocular/pigment changes with long‑term use."

  • Easy once-daily (one-and-done)

  • Latanoprost 0.005% provides reliable once‑daily IOP reduction and is widely used off‑label in dogs.

  • Easy once-daily (one-and-done)

  • Latanoprost 0.005% provides reliable once‑daily IOP reduction and is widely used off‑label in dogs.

Increased Safety & Security

Time-Saving Convenience

Xalatan (latanoprost) is widely regarded as a first-line topical prostaglandin analogue for acute intraocular pressure (IOP) lowering in dogs because of its rapid onset and strong IOP-reducing effect; its long history and availability as a generic translate into lower cost per dose compared with some newer branded alternatives. Compared with travoprost and bimatoprost, latanoprost often produces faster pressure drops, while it lacks the preservative-free delivery advantage of tafluprost (Zioptan) and the tolerability profile of lower-potency agents like unoprostone (Rescula).

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$60-120 CAD

2
BEST VETERINARY PRESCRIPTION DIAGNOSTIC OPHTHALMIC AGENTS FOR DOGS

Fluorescein Sodium Ophthalmic Strips USP

VetFluor Fluorescein Sodium Ophthalmic Strips USP

VetFluor is positioned as the market-leading fluorescein strip for veterinary use in dogs because it delivers a consistent, standardized 1 mg dye load per strip with sterile, single-use packaging that minimizes contamination risk and waste. Compared with the other diagnostics in this list, VetFluor offers the quickest and most cost-effective screening for corneal epithelial defects and foreign bodies, making it an economical frontline test that pairs well with Schirmer and Rose Bengal testing for comprehensive ocular assessment.

4.7
Show More Veterinary Prescription Diagnostic Ophthalmic Agents for Dogs
  • Highlights corneas

  • Instant fluorescent glow

  • Highlights corneas

  • Instant fluorescent glow

Review Summary

93%

"Users (veterinarians and techs) consistently praise fluorescein strips as simple, reliable, and highly effective for detecting corneal defects and tear-film problems; complaints are rare and usually limited to packaging or individual strip drying."

  • Single-use convenience

  • Single-use sterile strips for rapid corneal ulcer and abrasion detection

  • Single-use convenience

  • Single-use sterile strips for rapid corneal ulcer and abrasion detection

Increased Safety & Security

Time-Saving Convenience

VetFluor is positioned as the market-leading fluorescein strip for veterinary use in dogs because it delivers a consistent, standardized 1 mg dye load per strip with sterile, single-use packaging that minimizes contamination risk and waste. Compared with the other diagnostics in this list, VetFluor offers the quickest and most cost-effective screening for corneal epithelial defects and foreign bodies, making it an economical frontline test that pairs well with Schirmer and Rose Bengal testing for comprehensive ocular assessment.

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$10-30 CAD

3

Optixcare Eye Lube Plus is positioned as a veterinary-specific lubricant designed for canine ocular comfort and protection, offering a thicker, ointment-like gel that creates durable surface coating suitable for frequent use in dogs. Compared with the other products on this list, Optixcare's veterinary-focused formulation and tube packaging make it a cost-effective option for long-term management, trading some immediate visual clarity for extended surface retention that many clinicians prefer for maintenance therapy.

4.8
Show More Veterinary Prescription Ocular Lubricants and Tear Replacers for Dogs
  • Long-lasting moisture

  • Vet-formulated shield

  • Long-lasting moisture

  • Vet-formulated shield

Review Summary

95%

"Users consistently praise Optixcare Eye Lube Plus for its long-lasting, veterinary-grade lubrication that soothes severe dry eye and corneal issues; a minority mention the price and bulky dispenser as downsides."

  • Overnight snooze-proof

  • Veterinary-grade lubricant ointment providing long-lasting ocular protection for exposure and lubrication.

  • Overnight snooze-proof

  • Veterinary-grade lubricant ointment providing long-lasting ocular protection for exposure and lubrication.

Increased Safety & Security

Time-Saving Convenience

Optixcare Eye Lube Plus is positioned as a veterinary-specific lubricant designed for canine ocular comfort and protection, offering a thicker, ointment-like gel that creates durable surface coating suitable for frequent use in dogs. Compared with the other products on this list, Optixcare's veterinary-focused formulation and tube packaging make it a cost-effective option for long-term management, trading some immediate visual clarity for extended surface retention that many clinicians prefer for maintenance therapy.

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$20-40 CAD

4
BEST VETERINARY PRESCRIPTION MYDRIATICS AND MIOTICS FOR DOGS

Tropicamide 1% Ophthalmic Solution

Mydriacyl (Tropicamide 1%)

Mydriacyl is a fast‑acting, short‑duration tropicamide formulation widely used in veterinary ophthalmology for diagnostic mydriasis in dogs; its rapid onset and relatively brief effect make it the go‑to choice when brief pupil dilation is needed without prolonged cycloplegia. Compared with atropine and cyclopentolate it offers lower monitoring burden and quicker return of vision, and when paired with phenylephrine it provides predictable dilation at a modest cost, making it financially attractive for routine clinic use.

4.4
Show More Veterinary Prescription Mydriatics and Miotics for Dogs
  • Rapid dilation

  • Short duration

  • Rapid dilation

  • Short duration

Review Summary

88%

"Veterinarians and clinic staff generally find Tropicamide 1% fast-acting and reliable for routine mydriasis with a short, predictable duration; a few users report mild transient irritation or the need for repeat dosing during longer exams."

  • Examroom magic

  • Rapid onset within 15–30 minutes for pupil dilation

  • Examroom magic

  • Rapid onset within 15–30 minutes for pupil dilation

Time-Saving Convenience

Skill Development & Mastery

Mydriacyl is a fast‑acting, short‑duration tropicamide formulation widely used in veterinary ophthalmology for diagnostic mydriasis in dogs; its rapid onset and relatively brief effect make it the go‑to choice when brief pupil dilation is needed without prolonged cycloplegia. Compared with atropine and cyclopentolate it offers lower monitoring burden and quicker return of vision, and when paired with phenylephrine it provides predictable dilation at a modest cost, making it financially attractive for routine clinic use.

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$15-40 CAD

5
BEST VETERINARY PRESCRIPTION OPHTHALMIC ALLERGY TREATMENTS FOR DOGS

Optimmune Ophthalmic Ointment

Optimmune Ophthalmic Ointment

Optimmune (cyclosporine ophthalmic ointment) is best-in-class for chronic veterinary ophthalmic allergy in dogs because it provides a licensed, veterinary-specific, steroid-sparing immunomodulatory option with a long-acting ointment vehicle that supports less frequent dosing and improved owner compliance. Compared with compounded tacrolimus and short‑term corticosteroid suspensions, Optimmune offers predictable manufacturing and label support for chronic use, which can reduce downstream costs from steroid complications and repeated clinic visits.

4.4
Show More Veterinary Prescription Ophthalmic Allergy Treatments for Dogs
  • Long-lasting comfort

  • Owner-friendly dosing

  • Long-lasting comfort

  • Owner-friendly dosing

Review Summary

88%

"Long‑term users report significant improvement in tear production and comfort for dogs with dry eye or immune‑mediated corneal disease; the ointment is greasy, some dogs resist application, and it is relatively expensive."

  • Velcro-like cling

  • Contains cyclosporine ophthalmic ointment that modulates ocular immune response to increase tear production.

  • Velcro-like cling

  • Contains cyclosporine ophthalmic ointment that modulates ocular immune response to increase tear production.

Increased Safety & Security

Optimmune (cyclosporine ophthalmic ointment) is best-in-class for chronic veterinary ophthalmic allergy in dogs because it provides a licensed, veterinary-specific, steroid-sparing immunomodulatory option with a long-acting ointment vehicle that supports less frequent dosing and improved owner compliance. Compared with compounded tacrolimus and short‑term corticosteroid suspensions, Optimmune offers predictable manufacturing and label support for chronic use, which can reduce downstream costs from steroid complications and repeated clinic visits.

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$60-120 CAD

What the Research and Clinical Guidelines Say

Contemporary veterinary ophthalmology emphasizes diagnosis-driven treatment, safety around topical preservatives, and targeted use of systemic drugs when indicated. Research and clinical guidelines support culture and sensitivity testing for nonresponsive infections, the use of immunomodulators for chronic dry eye, careful use of topical corticosteroids only after ruling out corneal ulcers, and evidence-based glaucoma protocols. Below are accessible summaries of key findings that inform prescribing decisions.

Culture-guided therapy improves outcomes: Multiple clinical reports and guideline reviews in veterinary ophthalmology indicate that corneal cytology and bacterial culture with sensitivity testing reduce time to resolution and limit inappropriate antibiotic use.

Immunomodulators for KCS: Controlled studies and long-term case series have demonstrated that topical cyclosporine and tacrolimus increase tear production and reduce reliance on lubricants in dogs with keratoconjunctivitis sicca (KCS).

Glaucoma control: Prostaglandin analogues (where appropriate) and topical beta-blockers or carbonic anhydrase inhibitors are supported by clinical trials and consensus guidance for lowering intraocular pressure; drug selection depends on glaucoma type and contraindications.

Preservative toxicity matters: Research has documented that certain preservatives, notably benzalkonium chloride at repeated exposure, can damage the corneal epithelium in animals. Preservative-free or low-preservative options are preferred for chronic therapy or compromised corneas.

Topical antibiotics and fluoroquinolones: Broad-spectrum topical antibiotics are effective first-line choices for many bacterial keratitis cases, but culture and sensitivity testing is recommended for deep or nonhealing ulcers to prevent resistance and ensure targeted therapy.

Systemic agents in severe disease: Systemic antimicrobials or anti-inflammatory drugs are indicated for deep stromal infections, extension beyond the globe, or when topical penetration is inadequate. Evidence supports a combined topical and systemic approach for selected severe infections.

Owner compliance and dosing technique: Studies show that dosing frequency, ease of application (drops versus ointment), and clear client instruction significantly affect adherence and outcomes; practical training and written instructions improve success rates.

This curated category focuses on prescription ophthalmic treatments available and commonly recommended in Canada for 2025, with attention to diagnostic-driven therapy, preservative considerations, and practical application guidance. We hope you found the information you were looking for. If you want to narrow results by condition (for example, keratitis, KCS, or glaucoma), product type (drops, ointments, systemic), or availability in your province, use the search or filters to refine or expand your search.