Betoptic S 0.25% Ophthalmic Suspension
Betoptic S (betaxolol 0.25% suspension) is positioned as a cardioselective beta-1 blocker with a suspension formulation that can provide a favorable systemic safety profile for dogs with respiratory or cardiac sensitivity compared with nonselective timolol products. Although typically more expensive than generic timolol solutions, its technical advantage of beta-1 selectivity and a formulation designed for sustained ocular contact make it attractive for patients where reduced pulmonary side effects and targeted action are priorities.
Cardio-selective comfort
Suspension stays put
Cardio-selective comfort
Suspension stays put
Review Summary
"Betoptic S 0.25% is frequently praised for being better tolerated in dogs (less respiratory impact and less stinging) while still reducing IOP, though it is more expensive and availability can be limited. Long-term users appreciate the gentler side-effect profile."
Gentle-breathing friendly
Betaxolol (Betoptic S) is beta‑1 selective, reducing bronchoconstriction risk in airway‑sensitive dogs.
Gentle-breathing friendly
Betaxolol (Betoptic S) is beta‑1 selective, reducing bronchoconstriction risk in airway‑sensitive dogs.
Increased Safety & Security
Time-Saving Convenience
Betoptic S (betaxolol 0.25% suspension) is positioned as a cardioselective beta-1 blocker with a suspension formulation that can provide a favorable systemic safety profile for dogs with respiratory or cardiac sensitivity compared with nonselective timolol products. Although typically more expensive than generic timolol solutions, its technical advantage of beta-1 selectivity and a formulation designed for sustained ocular contact make it attractive for patients where reduced pulmonary side effects and targeted action are priorities.
Cardio-selective comfort
Suspension stays put
Gentle-breathing friendly
Betaxolol (Betoptic S) is beta‑1 selective, reducing bronchoconstriction risk in airway‑sensitive dogs.
Suspension formulation requires shaking and can improve corneal contact time.
Cardio-selective comfort
Suspension stays put
Gentle-breathing friendly
Betaxolol (Betoptic S) is beta‑1 selective, reducing bronchoconstriction risk in airway‑sensitive dogs.
Suspension formulation requires shaking and can improve corneal contact time.
$80-180 CAD
Azopt (Brinzolamide) 1% Ophthalmic Suspension
Azopt is the market-leading brinzolamide 1% suspension, valued in canine ophthalmology for a formulation that can be more comfortable and less stinging than acidic aqueous solutions. Compared with dorzolamide brands, Azopt often provides similar carbonic anhydrase inhibition with a distinct suspension profile — a technical advantage for tolerability in some dogs but sometimes at a higher branded price than generic monotherapies.
Creamy suspension
Clear vision aid
Creamy suspension
Clear vision aid
Review Summary
"Owners and veterinarians commonly praise brinzolamide for solid IOP control with less stinging than dorzolamide, though the suspension can blur vision briefly and requires shaking."
Smooth pour — tail-wag!
Brinzolamide 1% ophthalmic suspension reduces aqueous humor production via carbonic anhydrase inhibition.
Smooth pour — tail-wag!
Brinzolamide 1% ophthalmic suspension reduces aqueous humor production via carbonic anhydrase inhibition.
Increased Safety & Security
Time-Saving Convenience
Azopt is the market-leading brinzolamide 1% suspension, valued in canine ophthalmology for a formulation that can be more comfortable and less stinging than acidic aqueous solutions. Compared with dorzolamide brands, Azopt often provides similar carbonic anhydrase inhibition with a distinct suspension profile — a technical advantage for tolerability in some dogs but sometimes at a higher branded price than generic monotherapies.
Creamy suspension
Clear vision aid
Smooth pour — tail-wag!
Brinzolamide 1% ophthalmic suspension reduces aqueous humor production via carbonic anhydrase inhibition.
Suspension formulation may be better tolerated by some animals but requires shaking before use to ensure uniform dosing.
Creamy suspension
Clear vision aid
Smooth pour — tail-wag!
Brinzolamide 1% ophthalmic suspension reduces aqueous humor production via carbonic anhydrase inhibition.
Suspension formulation may be better tolerated by some animals but requires shaking before use to ensure uniform dosing.
$40-90 CAD
Neptazane 50mg Tablets
Neptazane 50mg (methazolamide, established brand) is valued for consistent manufacturing standards and predictable pharmacology, making it a reliable branded alternative when longer-duration systemic carbonic anhydrase inhibition is desired for dogs. Compared with generic methazolamide and acetazolamide products, Neptazane often carries a premium but is selected for perceived quality, batch consistency and clinician familiarity in sensitive or refractory glaucomatous cases.
Stable pressure control
Once-or twice-daily
Stable pressure control
Once-or twice-daily
Review Summary
"Neptazane 50mg (brand methazolamide) receives high marks for tolerability and steady IOP control in dogs, with users reporting fewer urinary side effects and better overall tolerance compared with acetazolamide."
Brand reliability — pharmacy favorite
Neptazane (brand methazolamide) provides a branded methazolamide option for systemic reduction of intraocular pressure in dogs.
Brand reliability — pharmacy favorite
Neptazane (brand methazolamide) provides a branded methazolamide option for systemic reduction of intraocular pressure in dogs.
Increased Safety & Security
Time-Saving Convenience
Neptazane 50mg (methazolamide, established brand) is valued for consistent manufacturing standards and predictable pharmacology, making it a reliable branded alternative when longer-duration systemic carbonic anhydrase inhibition is desired for dogs. Compared with generic methazolamide and acetazolamide products, Neptazane often carries a premium but is selected for perceived quality, batch consistency and clinician familiarity in sensitive or refractory glaucomatous cases.
Stable pressure control
Once-or twice-daily
Brand reliability — pharmacy favorite
Neptazane (brand methazolamide) provides a branded methazolamide option for systemic reduction of intraocular pressure in dogs.
Often chosen when acetazolamide is not tolerated; dosing is weight-based and may permit calmer dosing schedules due to pharmacokinetics.
Stable pressure control
Once-or twice-daily
Brand reliability — pharmacy favorite
Neptazane (brand methazolamide) provides a branded methazolamide option for systemic reduction of intraocular pressure in dogs.
Often chosen when acetazolamide is not tolerated; dosing is weight-based and may permit calmer dosing schedules due to pharmacokinetics.
$140-260 CAD
Xalatan (latanoprost) 0.005% ophthalmic solution
Xalatan (latanoprost) is widely regarded as a first-line topical prostaglandin analogue for acute intraocular pressure (IOP) lowering in dogs because of its rapid onset and strong IOP-reducing effect; its long history and availability as a generic translate into lower cost per dose compared with some newer branded alternatives. Compared with travoprost and bimatoprost, latanoprost often produces faster pressure drops, while it lacks the preservative-free delivery advantage of tafluprost (Zioptan) and the tolerability profile of lower-potency agents like unoprostone (Rescula).
Rapid IOP drop (zippy)
Proven track record (veteran)
Rapid IOP drop (zippy)
Proven track record (veteran)
Review Summary
"Veterinarians and dog owners report rapid, reliable intraocular pressure reduction with latanoprost in dogs, though many note transient ocular irritation, miosis and gradual periocular/pigment changes with long‑term use."
Easy once-daily (one-and-done)
Latanoprost 0.005% provides reliable once‑daily IOP reduction and is widely used off‑label in dogs.
Easy once-daily (one-and-done)
Latanoprost 0.005% provides reliable once‑daily IOP reduction and is widely used off‑label in dogs.
Increased Safety & Security
Time-Saving Convenience
Xalatan (latanoprost) is widely regarded as a first-line topical prostaglandin analogue for acute intraocular pressure (IOP) lowering in dogs because of its rapid onset and strong IOP-reducing effect; its long history and availability as a generic translate into lower cost per dose compared with some newer branded alternatives. Compared with travoprost and bimatoprost, latanoprost often produces faster pressure drops, while it lacks the preservative-free delivery advantage of tafluprost (Zioptan) and the tolerability profile of lower-potency agents like unoprostone (Rescula).
Rapid IOP drop (zippy)
Proven track record (veteran)
Easy once-daily (one-and-done)
Latanoprost 0.005% provides reliable once‑daily IOP reduction and is widely used off‑label in dogs.
Available as brand (Xalatan) and cheaper generics, increasing accessibility for long‑term treatment.
Rapid IOP drop (zippy)
Proven track record (veteran)
Easy once-daily (one-and-done)
Latanoprost 0.005% provides reliable once‑daily IOP reduction and is widely used off‑label in dogs.
Available as brand (Xalatan) and cheaper generics, increasing accessibility for long‑term treatment.
$60-120 CAD
Alphagan P 0.15% Ophthalmic Solution
Alphagan P 0.15% is positioned as a potent topical alpha-2 adrenergic agonist for canine glaucoma, offering a higher brimonidine concentration together with a Purite preservative designed to limit ocular surface toxicity. For the specific use case of topical antiglaucoma therapy in dogs it is often preferred for acute or refractory intraocular pressure elevation compared with the 0.1% formulation because of stronger IOP reduction, and though it typically carries a premium versus generic brimonidine it delivers a consistent proprietary formulation that can reduce the need for adjunctive agents.
Stronger pressure drop
Purite-preserved sparkle
Stronger pressure drop
Purite-preserved sparkle
Review Summary
"Long-term users report Alphagan P 0.15% frequently reduces intraocular pressure in dogs and is generally well tolerated, though some pets experience mild ocular irritation or transient lethargy. Many owners and vets consider it effective as part of chronic glaucoma management when monitored."
Rapidly soothing touch
Contains brimonidine 0.15%, an alpha-2 agonist used to reduce intraocular pressure in humans and commonly used off-label in dogs under veterinary guidance.
Rapidly soothing touch
Contains brimonidine 0.15%, an alpha-2 agonist used to reduce intraocular pressure in humans and commonly used off-label in dogs under veterinary guidance.
Increased Safety & Security
Time-Saving Convenience
Alphagan P 0.15% is positioned as a potent topical alpha-2 adrenergic agonist for canine glaucoma, offering a higher brimonidine concentration together with a Purite preservative designed to limit ocular surface toxicity. For the specific use case of topical antiglaucoma therapy in dogs it is often preferred for acute or refractory intraocular pressure elevation compared with the 0.1% formulation because of stronger IOP reduction, and though it typically carries a premium versus generic brimonidine it delivers a consistent proprietary formulation that can reduce the need for adjunctive agents.
Stronger pressure drop
Purite-preserved sparkle
Rapidly soothing touch
Contains brimonidine 0.15%, an alpha-2 agonist used to reduce intraocular pressure in humans and commonly used off-label in dogs under veterinary guidance.
Formulated with Purite preservative to minimize ocular surface irritation compared with older preservatives.
Stronger pressure drop
Purite-preserved sparkle
Rapidly soothing touch
Contains brimonidine 0.15%, an alpha-2 agonist used to reduce intraocular pressure in humans and commonly used off-label in dogs under veterinary guidance.
Formulated with Purite preservative to minimize ocular surface irritation compared with older preservatives.
$60-100 CAD
DuoTrav (travoprost-timolol)
DuoTrav brings together a prostaglandin analogue and a beta‑blocker, delivering some of the strongest IOP‑lowering seen in combination therapies and therefore often preferred in more advanced canine glaucoma cases. Its travoprost formulation and preservative system are positioned as a technical advantage for ocular tolerability compared with older prostaglandin combinations, but that premium positioning typically comes with higher acquisition cost versus generic prostaglandin/beta combos like Xalacom.
Prostaglandin powerhouse
Nighttime pressure cut
Prostaglandin powerhouse
Nighttime pressure cut
Review Summary
"DuoTrav receives high marks for potent pressure lowering with once‑daily dosing and good owner adherence, and most long‑term users report noticeable improvement with manageable side effects. A minority note local irritation or cost concerns but overall satisfaction is strong."
Once-daily snooze
Combines travoprost (prostaglandin analogue that increases uveoscleral outflow) with timolol for dual action
Once-daily snooze
Combines travoprost (prostaglandin analogue that increases uveoscleral outflow) with timolol for dual action
Increased Safety & Security
Time-Saving Convenience
DuoTrav brings together a prostaglandin analogue and a beta‑blocker, delivering some of the strongest IOP‑lowering seen in combination therapies and therefore often preferred in more advanced canine glaucoma cases. Its travoprost formulation and preservative system are positioned as a technical advantage for ocular tolerability compared with older prostaglandin combinations, but that premium positioning typically comes with higher acquisition cost versus generic prostaglandin/beta combos like Xalacom.
Prostaglandin powerhouse
Nighttime pressure cut
Once-daily snooze
Combines travoprost (prostaglandin analogue that increases uveoscleral outflow) with timolol for dual action
Typically dosed once daily (prostaglandin) with strong nocturnal IOP reduction—convenient for many regimens
Prostaglandin powerhouse
Nighttime pressure cut
Once-daily snooze
Combines travoprost (prostaglandin analogue that increases uveoscleral outflow) with timolol for dual action
Typically dosed once daily (prostaglandin) with strong nocturnal IOP reduction—convenient for many regimens
$120-220 CAD