Seachem ParaGuard
Seachem ParaGuard is a broad-spectrum antiparasitic and antifungal liquid formulated for both freshwater and marine systems. It stands out for concentrated dosing that treats a wide range of external and internal parasites without relying on food-based delivery, making it more flexible and often more cost-effective per treated volume than tablet-only or single-target products in this list.
Rapid parasite knockout!
Dual internal+external
Rapid parasite knockout!
Dual internal+external
Review Summary
"Most users find ParaGuard an effective broad‑spectrum medication that quickly clears many external parasites and helps with some internal issues, though it can stress sensitive fish and will harm invertebrates and sometimes requires repeat dosing."
Easy tank dosing
Broad-spectrum treatment for many external and internal parasites in aquarium fish.
Easy tank dosing
Broad-spectrum treatment for many external and internal parasites in aquarium fish.
Increased Safety & Security
Recreational Enjoyment
Time-Saving Convenience
Seachem ParaGuard is a broad-spectrum antiparasitic and antifungal liquid formulated for both freshwater and marine systems. It stands out for concentrated dosing that treats a wide range of external and internal parasites without relying on food-based delivery, making it more flexible and often more cost-effective per treated volume than tablet-only or single-target products in this list.
Rapid parasite knockout!
Dual internal+external
Easy tank dosing
Broad-spectrum treatment for many external and internal parasites in aquarium fish.
Rapid-acting liquid formulation for easy dosing of tanks and quarantine systems.
Rapid parasite knockout!
Dual internal+external
Easy tank dosing
Broad-spectrum treatment for many external and internal parasites in aquarium fish.
Rapid-acting liquid formulation for easy dosing of tanks and quarantine systems.
API General Cure
API General Cure is an economical, widely available internal parasite treatment favored by hobbyists who prioritize low cost per dose and a straightforward dosing regimen. Compared with Seachem's concentrated liquids it is less versatile for mixed systems but serves as a reliable, budget-conscious first-line option when a simple course-based therapy for internal parasites is desired.
Two-in-one formula!
Gentle on fish
Two-in-one formula!
Gentle on fish
Review Summary
"Reviewers commonly report API General Cure is an affordable, often effective option for tapeworms and other internal parasites, but results can be inconsistent and frequently require repeat treatments and careful water changes."
Simple instructions
Combines agents effective against internal helminths and some protozoan infections for comprehensive treatment.
Simple instructions
Combines agents effective against internal helminths and some protozoan infections for comprehensive treatment.
Increased Safety & Security
Recreational Enjoyment
Time-Saving Convenience
API General Cure is an economical, widely available internal parasite treatment favored by hobbyists who prioritize low cost per dose and a straightforward dosing regimen. Compared with Seachem's concentrated liquids it is less versatile for mixed systems but serves as a reliable, budget-conscious first-line option when a simple course-based therapy for internal parasites is desired.
Two-in-one formula!
Gentle on fish
Simple instructions
Combines agents effective against internal helminths and some protozoan infections for comprehensive treatment.
Affordable, commonly used for routine aquarium parasite protocols and spot treatments.
Two-in-one formula!
Gentle on fish
Simple instructions
Combines agents effective against internal helminths and some protozoan infections for comprehensive treatment.
Affordable, commonly used for routine aquarium parasite protocols and spot treatments.
$6-15 CAD
Hikari PraziPro
Hikari PraziPro is a targeted, professional-grade option for treating tapeworms and fluke infections, prized for its high efficacy when a specific helminth infection is known. Although typically higher in price per treatment than broad-spectrum alternatives, its focused action makes it the market leader for precision therapy where other products on this list would be less specific or require combination use.
High-dose praziquantel!
Micro-dose convenience
High-dose praziquantel!
Micro-dose convenience
Review Summary
"Hikari PraziPro is widely praised for rapid, reliable removal of tapeworms and flukes with easy, concentrated dosing; the main caveat in reviews is toxicity to shrimp/snails and occasional need for follow‑up treatments for heavy infestations."
Minimal water change
High-concentration praziquantel liquid specifically effective against tapeworms and flukes.
Minimal water change
High-concentration praziquantel liquid specifically effective against tapeworms and flukes.
Increased Safety & Security
Time-Saving Convenience
Hikari PraziPro is a targeted, professional-grade option for treating tapeworms and fluke infections, prized for its high efficacy when a specific helminth infection is known. Although typically higher in price per treatment than broad-spectrum alternatives, its focused action makes it the market leader for precision therapy where other products on this list would be less specific or require combination use.
High-dose praziquantel!
Micro-dose convenience
Minimal water change
High-concentration praziquantel liquid specifically effective against tapeworms and flukes.
Concentrated formula allows flexible dosing for tanks and medicated baths.
High-dose praziquantel!
Micro-dose convenience
Minimal water change
High-concentration praziquantel liquid specifically effective against tapeworms and flukes.
Concentrated formula allows flexible dosing for tanks and medicated baths.
$12-30 CAD
Fritz ParaCleanse
Fritz ParaCleanse is an aquarium-oriented internal dewormer designed to minimize stress on community fish through a gentle, user-friendly protocol. It competes by offering simple dosing packs and proven compatibility with common aquarium setups, providing a mid-range financial and technical choice between single-agent precision products and concentrated repeat-use formulations.
Gut-targeted cleanse!
Broad internal reach
Gut-targeted cleanse!
Broad internal reach
Review Summary
"Fritz ParaCleanse receives positive feedback for consistently treating internal worms and flagellates, with many users reporting clear improvement, though reviewers note the treatment course can be long, somewhat pricey, and risky for invertebrates."
Pond & tank safe
Medicated food formulation designed to deliver internal antiparasitic agents via ingestion for targeted gut parasite treatment.
Pond & tank safe
Medicated food formulation designed to deliver internal antiparasitic agents via ingestion for targeted gut parasite treatment.
Increased Safety & Security
Recreational Enjoyment
Fritz ParaCleanse is an aquarium-oriented internal dewormer designed to minimize stress on community fish through a gentle, user-friendly protocol. It competes by offering simple dosing packs and proven compatibility with common aquarium setups, providing a mid-range financial and technical choice between single-agent precision products and concentrated repeat-use formulations.
Gut-targeted cleanse!
Broad internal reach
Pond & tank safe
Medicated food formulation designed to deliver internal antiparasitic agents via ingestion for targeted gut parasite treatment.
Convenient for treating schooling and small fish that readily accept medicated food.
Gut-targeted cleanse!
Broad internal reach
Pond & tank safe
Medicated food formulation designed to deliver internal antiparasitic agents via ingestion for targeted gut parasite treatment.
Convenient for treating schooling and small fish that readily accept medicated food.
$15-30 CAD
Seachem Metroplex
Seachem MetroPlex is a water-soluble formulation optimized for treating protozoan parasites and anaerobic-associated internal infections. As part of Seachem's treatment suite it offers clear technical synergy with ParaGuard for combined or sequential therapies; while narrower in spectrum on its own, its powdered format allows precise dosing and can be more economical for repeated or follow-up courses.
Metronidazole power!
Long-lasting action
Metronidazole power!
Long-lasting action
Review Summary
"Seachem MetroPlex is often reported to help with protozoan infections and anaerobic bacteria (e.g., hexamita), delivering good results for many hobbyists, but some find it slower acting and less effective on certain parasites compared with alternatives."
No daily water swaps
Formulated to target intestinal protozoans (e.g., Hexamita) and certain anaerobic bacterial infections.
No daily water swaps
Formulated to target intestinal protozoans (e.g., Hexamita) and certain anaerobic bacterial infections.
Increased Safety & Security
Time-Saving Convenience
Recreational Enjoyment
Seachem MetroPlex is a water-soluble formulation optimized for treating protozoan parasites and anaerobic-associated internal infections. As part of Seachem's treatment suite it offers clear technical synergy with ParaGuard for combined or sequential therapies; while narrower in spectrum on its own, its powdered format allows precise dosing and can be more economical for repeated or follow-up courses.
Metronidazole power!
Long-lasting action
No daily water swaps
Formulated to target intestinal protozoans (e.g., Hexamita) and certain anaerobic bacterial infections.
Liquid medication suitable for bath dosing or whole-tank treatment with clear directions.
Metronidazole power!
Long-lasting action
No daily water swaps
Formulated to target intestinal protozoans (e.g., Hexamita) and certain anaerobic bacterial infections.
Liquid medication suitable for bath dosing or whole-tank treatment with clear directions.