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2025 Canadian Guide: Top 5 Roundworm and Hookworm Dewormers for Small Animals - Veterinarian Reviewed Options Safe for Puppies and Pregnant Pets | Which One Fits Your Needs?

Published on Thursday, August 21, 2025

This category covers proven deworming products targeting common nematode infections in small animals, including roundworms and hookworms. Products listed here emphasize fast acting formulas, reliable follow up dosing schedules, and options that are considered safe for young animals and pregnant females when used as indicated. Canadian pet owners tend to choose treatments that combine strong clinical efficacy with ease of administration, palatable formulations, clear dosing guidance, and veterinarian endorsement. That preference drives demand for chewable tablets, flavored tablets, and granules that can be mixed with food, plus multi-parasite products that simplify prevention and treatment in multi-pet households.

Quick Menu

1. Best Broad-spectrum Flavoured Tablet

2. Best Fenbendazole Granules for Small Animals

3. Best Puppy-Friendly Chewable Option

4. Best Combination for Broad Parasite Control

5. Best Topical for Combined Heartworm and Intestinal Control

1
BEST BROAD-SPECTRUM FLAVOURED TABLET

Drontal Plus Flavour Tablets for Dogs

Bayer

Drontal Plus is a broad‑spectrum, palatable tablet that combines active ingredients to treat roundworms, hookworms and tapeworms in a single dose, making it a go‑to for fast, on‑the‑spot intestinal parasite control. It holds its position for cost‑effective, clinic‑friendly deworming compared with multi‑day granule regimens like Panacur, while offering a simpler oral alternative to topical combination products such as Advantage Multi and monthly preventives like Interceptor Plus.

4.5
★★★★☆
  • Triple-worm knockout

  • Tasty beef treat

  • Triple-worm knockout

  • Tasty beef treat

Review Summary

88%

"Widely praised as a broad‑spectrum, fast‑acting and generally palatable tablet that reliably clears roundworms, hookworms and tapeworms; a minority of owners note tablet size can be large for very small dogs or cause occasional mild GI upset."

  • Fast symptom relief

  • Contains praziquantel, pyrantel and febantel for effective treatment of roundworms, hookworms and tapeworms.

  • Fast symptom relief

  • Contains praziquantel, pyrantel and febantel for effective treatment of roundworms, hookworms and tapeworms.

Increased Safety & Security

Time-Saving Convenience

Drontal Plus is a broad‑spectrum, palatable tablet that combines active ingredients to treat roundworms, hookworms and tapeworms in a single dose, making it a go‑to for fast, on‑the‑spot intestinal parasite control. It holds its position for cost‑effective, clinic‑friendly deworming compared with multi‑day granule regimens like Panacur, while offering a simpler oral alternative to topical combination products such as Advantage Multi and monthly preventives like Interceptor Plus.

  • Triple-worm knockout

  • Tasty beef treat

  • Fast symptom relief

  • Contains praziquantel, pyrantel and febantel for effective treatment of roundworms, hookworms and tapeworms.

  • Palatable chewable tablets to simplify dosing for dogs that resist pills.

  • Triple-worm knockout

  • Tasty beef treat

  • Fast symptom relief

  • Contains praziquantel, pyrantel and febantel for effective treatment of roundworms, hookworms and tapeworms.

  • Palatable chewable tablets to simplify dosing for dogs that resist pills.

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-8%59.99$
Suggested Price: 64.99$
2
BEST FENBENDAZOLE GRANULES FOR SMALL ANIMALS

Panacur Granules 22.2%

Panacur Granules 22.2%

Panacur (fenbendazole) granules are a flexible, veterinary‑proven option for roundworm and hookworm control that can be dosed over multiple days and adjusted precisely for small or young animals, and are widely used where tailored regimens are preferred. While it typically requires several days of treatment unlike single‑dose chewables such as Drontal or Milbemax, Panacur's generic availability and ease of dose titration give it a financial and technical advantage for long or targeted treatment courses.

4.7
★★★★☆
  • Broad-spectrum hero

  • Mix-and-go granules

  • Broad-spectrum hero

  • Mix-and-go granules

Review Summary

92%

"Trusted fenbendazole granules known for excellent safety and high efficacy across multiple parasite types; reviewers appreciate tolerability and ease of mixing with food but frequently note the need for multi‑day dosing regimens for full clearance."

  • Flexible dosing

  • 22.2% fenbendazole granules effective against roundworms, hookworms and whipworms with flexible off-label uses.

  • Flexible dosing

  • 22.2% fenbendazole granules effective against roundworms, hookworms and whipworms with flexible off-label uses.

Time-Saving Convenience

Skill Development & Mastery

Panacur (fenbendazole) granules are a flexible, veterinary‑proven option for roundworm and hookworm control that can be dosed over multiple days and adjusted precisely for small or young animals, and are widely used where tailored regimens are preferred. While it typically requires several days of treatment unlike single‑dose chewables such as Drontal or Milbemax, Panacur's generic availability and ease of dose titration give it a financial and technical advantage for long or targeted treatment courses.

  • Broad-spectrum hero

  • Mix-and-go granules

  • Flexible dosing

  • 22.2% fenbendazole granules effective against roundworms, hookworms and whipworms with flexible off-label uses.

  • Granule formulation can be easily mixed with food for dogs, cats and some small mammals.

  • Broad-spectrum hero

  • Mix-and-go granules

  • Flexible dosing

  • 22.2% fenbendazole granules effective against roundworms, hookworms and whipworms with flexible off-label uses.

  • Granule formulation can be easily mixed with food for dogs, cats and some small mammals.

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$30-80 CAD

3
BEST PUPPY-FRIENDLY CHEWABLE OPTION

Milbemax Chewable Tablets for Dogs

Milbemax Chewable Tablets for Dogs

Milbemax chewables combine milbemycin oxime and praziquantel to deliver convenient, single‑tablet coverage against roundworms, hookworms and tapeworms, offering a strong balance of palatability and spectrum for routine deworming. Positioned between budget multi‑day products and premium combination preventives, Milbemax gives clinics and owners a mid‑range, single‑treatment option that avoids the longer dosing of fenbendazole granules and the broader systemic protection (and cost) of products like Interceptor Plus or Advantage Multi.

4.4
★★★★☆
  • Chewable convenience

  • Broad parasite coverage

  • Chewable convenience

  • Broad parasite coverage

Review Summary

86%

"Convenient, palatable chewable that many owners find effective against roundworms, hookworms and tapeworms; occasional reports of mild vomiting or diarrhea and emphasis on accurate weight‑based dosing."

  • Treat-like tablet

  • Contains milbemycin oxime and praziquantel to control roundworms, hookworms and tapeworms and assist with heartworm prevention.

  • Treat-like tablet

  • Contains milbemycin oxime and praziquantel to control roundworms, hookworms and tapeworms and assist with heartworm prevention.

Increased Safety & Security

Time-Saving Convenience

Milbemax chewables combine milbemycin oxime and praziquantel to deliver convenient, single‑tablet coverage against roundworms, hookworms and tapeworms, offering a strong balance of palatability and spectrum for routine deworming. Positioned between budget multi‑day products and premium combination preventives, Milbemax gives clinics and owners a mid‑range, single‑treatment option that avoids the longer dosing of fenbendazole granules and the broader systemic protection (and cost) of products like Interceptor Plus or Advantage Multi.

  • Chewable convenience

  • Broad parasite coverage

  • Treat-like tablet

  • Contains milbemycin oxime and praziquantel to control roundworms, hookworms and tapeworms and assist with heartworm prevention.

  • Flavoured chewable tablets improve acceptance in puppies and adult dogs.

  • Chewable convenience

  • Broad parasite coverage

  • Treat-like tablet

  • Contains milbemycin oxime and praziquantel to control roundworms, hookworms and tapeworms and assist with heartworm prevention.

  • Flavoured chewable tablets improve acceptance in puppies and adult dogs.

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$35-120 CAD

4
BEST COMBINATION FOR BROAD PARASITE CONTROL

Interceptor Plus Chewable Tablets

Interceptor Plus Chewable Tablets

Interceptor Plus provides monthly oral protection that not only treats roundworms and hookworms but also adds heartworm prevention and expanded intestinal parasite control in one chewable, making it a market leader for comprehensive monthly parasite management. Its technical advantage is the preventive, ongoing coverage that reduces the need for separate deworming courses—which typically raises upfront cost—yet can be more economical long‑term compared with purchasing multiple single‑purpose products.

4.5
★★★★☆
  • Heartworm + intestinal

  • Monthly peace-of-mind

  • Heartworm + intestinal

  • Monthly peace-of-mind

Review Summary

87%

"Well regarded monthly chewable offering combined heartworm and intestinal parasite protection with good efficacy and ease of administration; common minor complaints are cost and rare short‑lived side effects in sensitive animals."

  • Vet-trusted formula

  • Combines milbemycin oxime with afoxolaner to prevent heartworm and control intestinal nematodes including roundworms and hookworms while addressing fleas/ticks.

  • Vet-trusted formula

  • Combines milbemycin oxime with afoxolaner to prevent heartworm and control intestinal nematodes including roundworms and hookworms while addressing fleas/ticks.

Increased Safety & Security

Time-Saving Convenience

Interceptor Plus provides monthly oral protection that not only treats roundworms and hookworms but also adds heartworm prevention and expanded intestinal parasite control in one chewable, making it a market leader for comprehensive monthly parasite management. Its technical advantage is the preventive, ongoing coverage that reduces the need for separate deworming courses—which typically raises upfront cost—yet can be more economical long‑term compared with purchasing multiple single‑purpose products.

  • Heartworm + intestinal

  • Monthly peace-of-mind

  • Vet-trusted formula

  • Combines milbemycin oxime with afoxolaner to prevent heartworm and control intestinal nematodes including roundworms and hookworms while addressing fleas/ticks.

  • Monthly chewable tablet format supports year-round prevention programs.

  • Heartworm + intestinal

  • Monthly peace-of-mind

  • Vet-trusted formula

  • Combines milbemycin oxime with afoxolaner to prevent heartworm and control intestinal nematodes including roundworms and hookworms while addressing fleas/ticks.

  • Monthly chewable tablet format supports year-round prevention programs.

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$60-160 CAD

5
BEST TOPICAL FOR COMBINED HEARTWORM AND INTESTINAL CONTROL

Advantage Multi for Dogs

Advantage Multi for Dogs

Advantage Multi is a topical combination (imidacloprid + moxidectin) that simultaneously treats fleas and provides systemic control of roundworms and hookworms while preventing heartworm disease, offering a highly convenient monthly topical route for multi‑parasite protection. As a bundled, multipurpose product it often reduces overall spend and handling compared with buying separate dewormers and flea control, and is a strong choice where topical application and combined external/internal parasite control are priorities.

4.2
★★★★☆
  • Topical all-in-one

  • Water-resistant dose

  • Topical all-in-one

  • Water-resistant dose

Review Summary

83%

"Convenient once‑monthly topical that many users report is effective for heartworm prevention and control of roundworms/hookworms while also reducing fleas; some owners report localized skin irritation, odor or reduced effectiveness if the dog is bathed soon after application."

  • One-drop wizardry

  • Topical formulation of imidacloprid and moxidectin that prevents heartworm and controls certain intestinal parasites including roundworms and hookworms.

  • One-drop wizardry

  • Topical formulation of imidacloprid and moxidectin that prevents heartworm and controls certain intestinal parasites including roundworms and hookworms.

Increased Safety & Security

Time-Saving Convenience

Advantage Multi is a topical combination (imidacloprid + moxidectin) that simultaneously treats fleas and provides systemic control of roundworms and hookworms while preventing heartworm disease, offering a highly convenient monthly topical route for multi‑parasite protection. As a bundled, multipurpose product it often reduces overall spend and handling compared with buying separate dewormers and flea control, and is a strong choice where topical application and combined external/internal parasite control are priorities.

  • Topical all-in-one

  • Water-resistant dose

  • One-drop wizardry

  • Topical formulation of imidacloprid and moxidectin that prevents heartworm and controls certain intestinal parasites including roundworms and hookworms.

  • Monthly spot-on application offers a non-oral alternative for animals that are difficult to pill.

  • Topical all-in-one

  • Water-resistant dose

  • One-drop wizardry

  • Topical formulation of imidacloprid and moxidectin that prevents heartworm and controls certain intestinal parasites including roundworms and hookworms.

  • Monthly spot-on application offers a non-oral alternative for animals that are difficult to pill.

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$80-200 CAD

What the Research Says about Deworming Efficacy and Safety

Clinical trials and veterinary guidelines support the use of the active ingredients found in these five products for effective control of roundworm and hookworm infections. Research emphasizes matching the drug class to the parasite, following recommended dosing schedules, and combining medical treatment with environmental hygiene to prevent reinfection. Several well-established actives, such as fenbendazole, pyrantel, praziquantel, milbemycin oxime, and moxidectin, have strong evidence bases for safety and efficacy in both routine and targeted deworming programs.

Fenbendazole (Panacur) has long-standing clinical evidence for reliably eliminating Toxocara and Ancylostoma species and is notable for documented safety in pregnant bitches and young animals when used at recommended regimens.

Pyrantel-based combinations, as found in products like Drontal Plus, provide rapid neuromuscular paralysis of roundworms and hookworms, supporting quick expulsion and symptomatic improvement.

Praziquantel combined with milbemycin oxime or other actives expands coverage to include certain tapeworms while maintaining proven efficacy against intestinal nematodes in licensed clinical trials.

Moxidectin-containing topical formulations, such as Advantage Multi, and oral macrocyclic lactones provide broad nematode control and add value for integrated parasite prevention when heartworm protection is also a priority.

Veterinary guidance and peer-reviewed control strategies recommend scheduled follow-up dosing (often repeating treatment after 2 to 4 weeks in high-risk settings) and fecal monitoring to confirm elimination and to guide any needed retreatment.

In Canada the five options profiled here each serve clear roles: Drontal Plus Flavour Tablets for Dogs offers a fast-acting, palatable tablet for broad intestinal worm control; Panacur Granules 22.2% (fenbendazole) is a trusted, pregnancy-safe choice with flexible dosing; Milbemax Chewable Tablets for Dogs delivers a convenient chewable with broad nematode and cestode coverage; Interceptor Plus Chewable Tablets combines heartworm prevention with roundworm and hookworm treatment; and Advantage Multi for Dogs provides topical, combined flea, heartworm and nematode control using moxidectin. For owners prioritizing safety in young and pregnant animals while retaining broad nematode efficacy, Panacur Granules 22.2% is often the best single choice on this list. We hope you found what you were looking for. You can refine or expand your search using the site search to compare dosages, age and weight guides, or veterinarian recommendations for your pet.

Discover More
  • Oral Dewormer Tablets for Intestinal Parasites in Small Animals
  • Oral Dewormer Liquids for Intestinal Parasites in Small Animals
  • Injectable Dewormers for Intestinal Parasites in Small Animals
  • Broad Spectrum Combination Dewormers for Intestinal Parasites in Small Animals
  • Tapeworm Dewormers for Intestinal Parasites in Small Animals
  • Deworming Kits and Prevention Protocols for Intestinal Parasites in Small Animals
  • Single Ingredient Anthelmintics for Intestinal Parasites in Small Animals

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