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Top 5 Antioxidant Complexes in Canada 2025: Vet-Backed Vitamin C & E Blends for Small Animals — Evidence-Based Picks to Reduce Oxidative Stress

Published on Thursday, August 21, 2025

Antioxidant complexes centered on vitamin C and vitamin E combine classic, clinically studied antioxidants with complementary compounds such as polyphenols, omega fatty acids, and probiotics to reduce oxidative stress and support cellular immune function in small animals. These formulations are appealing to Canadian pet owners and veterinarians because they target common, age-related and inflammatory pathways—helping protect tissues during infection, aging, and chronic inflammatory conditions—while often offering palatable delivery formats (chews, liquids, or capsules) and clear ingredient sourcing. In the 2025 Canadian market, demand is driven by an aging pet population, increased vet recommendation of nutraceutical strategies, interest in multi-benefit formulas that pair antioxidants with joint or digestive support, and a preference for products with transparent labeling and third-party quality checks.

Quick Menu

1. Best Budget Antioxidant Blend

2. Best Advanced Antioxidant Formula

3. Best Everyday Value Antioxidants

4. Best Veterinary-Grade Antioxidant Support

5. Best Omega-Enriched Antioxidant Mobility

1
BEST BUDGET ANTIOXIDANT BLEND

NaturVet VitaPet Senior Daily Vitamins Plus Glucosamine

NaturVet

NaturVet VitaPet Senior holds a best-in-class position for pet owners seeking an affordable, all-in-one senior formula that pairs basic antioxidant support (notably Vitamin E and commonly included Vitamin C) with glucosamine for joint health. Its primary advantage is a cost-effective combination of antioxidant protection and mobility support in a single daily chew, making it a budget-friendly alternative to more specialized antioxidant blends listed here. Compared with premium multivitamins like Zesty Paws and VetriScience, NaturVet trades some ingredient concentration for broader value and wider retail availability.

4.2
★★★★☆
  • Senior joint boost (wag!)

  • Antioxidant skin shine (citrus zap)

  • Senior joint boost (wag!)

  • Antioxidant skin shine (citrus zap)

Review Summary

76%

"Users commonly report this senior multivitamin with glucosamine is palatable and helpful for overall senior dog vitality, though a minority say they saw little joint improvement or that their dog refused the chew. Packaging and scent are occasionally mentioned as negatives."

  • Easy chew delight (senior hug)

  • Formulated for senior dogs with added joint support and general multivitamin coverage.

  • Easy chew delight (senior hug)

  • Formulated for senior dogs with added joint support and general multivitamin coverage.

Self-Improvement & Personal Growth

Time-Saving Convenience

NaturVet VitaPet Senior holds a best-in-class position for pet owners seeking an affordable, all-in-one senior formula that pairs basic antioxidant support (notably Vitamin E and commonly included Vitamin C) with glucosamine for joint health. Its primary advantage is a cost-effective combination of antioxidant protection and mobility support in a single daily chew, making it a budget-friendly alternative to more specialized antioxidant blends listed here. Compared with premium multivitamins like Zesty Paws and VetriScience, NaturVet trades some ingredient concentration for broader value and wider retail availability.

  • Senior joint boost (wag!)

  • Antioxidant skin shine (citrus zap)

  • Easy chew delight (senior hug)

  • Formulated for senior dogs with added joint support and general multivitamin coverage.

  • Provides antioxidant nutrients and supportive vitamins intended to complement diet.

  • Senior joint boost (wag!)

  • Antioxidant skin shine (citrus zap)

  • Easy chew delight (senior hug)

  • Formulated for senior dogs with added joint support and general multivitamin coverage.

  • Provides antioxidant nutrients and supportive vitamins intended to complement diet.

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From 33.48$
2
BEST ADVANCED ANTIOXIDANT FORMULA

Zesty Paws Advanced Multivitamin for Dogs

Zesty Paws

Zesty Paws Advanced Multivitamin is a market leader for pet antioxidant complexes thanks to a higher-potency, flavor-forward soft chew formulation that emphasizes Vitamins C and E alongside botanical antioxidants for enhanced free-radical protection. Its technical advantage is a consumer-friendly delivery and perceived premium ingredient profile, which supports a higher price point but often better palatability and targeted nutrient dosing versus basic chewables. When compared to Nutri-Vet and NaturVet, Zesty Paws is positioned as a premium, taste-focused option for owners prioritizing potency and compliance.

4.6
★★★★☆
  • Immune antioxidant kick (zesty pop)

  • Coat glossy wow (lickable!)

  • Immune antioxidant kick (zesty pop)

  • Coat glossy wow (lickable!)

Review Summary

86%

"Buyers praise Zesty Paws for high palatability and noticeable improvements in coat, energy, and general health; a few reviewers reported mild stomach upset or no clear benefit. Overall it's regarded as a reliable, premium multivitamin option."

  • Flavor-first chew (paw-pleaser)

  • Broad-spectrum multivitamin designed to include antioxidants alongside key minerals.

  • Flavor-first chew (paw-pleaser)

  • Broad-spectrum multivitamin designed to include antioxidants alongside key minerals.

Recreational Enjoyment

Self-Improvement & Personal Growth

Zesty Paws Advanced Multivitamin is a market leader for pet antioxidant complexes thanks to a higher-potency, flavor-forward soft chew formulation that emphasizes Vitamins C and E alongside botanical antioxidants for enhanced free-radical protection. Its technical advantage is a consumer-friendly delivery and perceived premium ingredient profile, which supports a higher price point but often better palatability and targeted nutrient dosing versus basic chewables. When compared to Nutri-Vet and NaturVet, Zesty Paws is positioned as a premium, taste-focused option for owners prioritizing potency and compliance.

  • Immune antioxidant kick (zesty pop)

  • Coat glossy wow (lickable!)

  • Flavor-first chew (paw-pleaser)

  • Broad-spectrum multivitamin designed to include antioxidants alongside key minerals.

  • Often contains concentrated antioxidant ingredients aimed at immune and cellular support.

  • Immune antioxidant kick (zesty pop)

  • Coat glossy wow (lickable!)

  • Flavor-first chew (paw-pleaser)

  • Broad-spectrum multivitamin designed to include antioxidants alongside key minerals.

  • Often contains concentrated antioxidant ingredients aimed at immune and cellular support.

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From 39.97$
3
BEST EVERYDAY VALUE ANTIOXIDANTS

Nutri-Vet Multi-Vite Chewables for Dogs

Nutri-Vet

Nutri-Vet Multi-Vite Chewables is recognized as a dependable, low-cost multivitamin that typically includes essential antioxidants such as Vitamin E and supportive vitamin complex components suitable for routine antioxidant maintenance. Its financial advantage is consistent affordability and broad distribution, making it a practical everyday supplement compared with higher-priced specialty blends like Zesty Paws or vet-formulated products. Technically it offers straightforward nutrient coverage rather than the higher concentrations or joint-targeted delivery seen in Omega Alpha or VetriScience formulas.

4.4
★★★★☆
  • Daily nutrient cover (vet-tested)

  • Antioxidant boost (citrus hint)

  • Daily nutrient cover (vet-tested)

  • Antioxidant boost (citrus hint)

Review Summary

82%

"Nutri-Vet chewables are frequently noted for good value, easy dosing, and being well-accepted by most dogs, though some owners report inconsistent results or occasional packaging issues. It's seen as an affordable everyday multivitamin."

  • Chewable convenience (no-pill drama)

  • Value-oriented chewable multivitamin providing core vitamins and antioxidants for maintenance.

  • Chewable convenience (no-pill drama)

  • Value-oriented chewable multivitamin providing core vitamins and antioxidants for maintenance.

Time-Saving Convenience

Self-Improvement & Personal Growth

Nutri-Vet Multi-Vite Chewables is recognized as a dependable, low-cost multivitamin that typically includes essential antioxidants such as Vitamin E and supportive vitamin complex components suitable for routine antioxidant maintenance. Its financial advantage is consistent affordability and broad distribution, making it a practical everyday supplement compared with higher-priced specialty blends like Zesty Paws or vet-formulated products. Technically it offers straightforward nutrient coverage rather than the higher concentrations or joint-targeted delivery seen in Omega Alpha or VetriScience formulas.

  • Daily nutrient cover (vet-tested)

  • Antioxidant boost (citrus hint)

  • Chewable convenience (no-pill drama)

  • Value-oriented chewable multivitamin providing core vitamins and antioxidants for maintenance.

  • Simple ingredient profile aimed at routine supplementation for adult dogs.

  • Daily nutrient cover (vet-tested)

  • Antioxidant boost (citrus hint)

  • Chewable convenience (no-pill drama)

  • Value-oriented chewable multivitamin providing core vitamins and antioxidants for maintenance.

  • Simple ingredient profile aimed at routine supplementation for adult dogs.

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From 26.99$
4
BEST VETERINARY-GRADE ANTIOXIDANT SUPPORT

VetriScience Canine Plus Senior Multivitamin

VetriScience Canine Plus Senior Multivitamin

VetriScience Canine Plus is a market leader among veterinarian-formulated antioxidant complexes, offering a scientifically oriented ingredient profile that emphasizes bioavailable forms of Vitamins C and E alongside complementary cofactors for senior dogs. Its technical strength lies in professional-grade formulation and manufacturing standards, which justify a premium price and often higher efficacy claims relative to off-the-shelf chewables. Compared to the value-oriented NaturVet and Nutri-Vet, VetriScience targets owners and clinicians seeking clinically minded antioxidant dosing and formulation transparency.

4.7
★★★★☆
  • Targeted senior care (lab-smart)

  • Antioxidant immune help (E+C punch)

  • Targeted senior care (lab-smart)

  • Antioxidant immune help (E+C punch)

Review Summary

88%

"VetriScience Canine Plus is often recommended by owners and vets for senior dogs — reviewers cite quality ingredients and measurable improvements in energy and mobility, with most finding it worth the price. A few note cost and occasional lack of effect for some pets."

  • Soft tablet ease (golden years)

  • Veterinary-focused formula with targeted antioxidant support and complementary nutrients.

  • Soft tablet ease (golden years)

  • Veterinary-focused formula with targeted antioxidant support and complementary nutrients.

Self-Improvement & Personal Growth

Time-Saving Convenience

VetriScience Canine Plus is a market leader among veterinarian-formulated antioxidant complexes, offering a scientifically oriented ingredient profile that emphasizes bioavailable forms of Vitamins C and E alongside complementary cofactors for senior dogs. Its technical strength lies in professional-grade formulation and manufacturing standards, which justify a premium price and often higher efficacy claims relative to off-the-shelf chewables. Compared to the value-oriented NaturVet and Nutri-Vet, VetriScience targets owners and clinicians seeking clinically minded antioxidant dosing and formulation transparency.

  • Targeted senior care (lab-smart)

  • Antioxidant immune help (E+C punch)

  • Soft tablet ease (golden years)

  • Veterinary-focused formula with targeted antioxidant support and complementary nutrients.

  • Designed for senior dogs with emphasis on immune health and healthy aging.

  • Targeted senior care (lab-smart)

  • Antioxidant immune help (E+C punch)

  • Soft tablet ease (golden years)

  • Veterinary-focused formula with targeted antioxidant support and complementary nutrients.

  • Designed for senior dogs with emphasis on immune health and healthy aging.

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$45-70 CAD

5
BEST OMEGA-ENRICHED ANTIOXIDANT MOBILITY

Omega Alpha E-Z Mobility

Omega Alpha

Omega Alpha E-Z Mobility is positioned as a specialized mobility product that integrates antioxidant support (commonly including Vitamin E, with Vitamin C often present in formulations) into a joint-focused delivery system, giving it a technical edge for dogs where oxidative stress and cartilage support are both concerns. Its advantage is targeted joint support—frequently delivered as a liquid or concentrated dose—allowing for adjunctive antioxidant therapy alongside primary mobility actives, which can be more cost-effective for pets needing focused treatment versus broad-spectrum multivitamins. In comparison with broad multivitamins like Zesty Paws or Nutri-Vet, Omega Alpha prioritizes mobility outcomes while still contributing antioxidant benefits.

4.1
★★★★☆
  • Mobility lubricant (easy-swipe)

  • Antioxidant inflammation aid (Vit C+E zip)

  • Mobility lubricant (easy-swipe)

  • Antioxidant inflammation aid (Vit C+E zip)

Review Summary

73%

"Omega Alpha E-Z Mobility receives mixed but generally positive feedback: many owners see joint comfort benefits, while others report minimal change or palatability issues. It is considered effective for some dogs but not universally consistent."

  • Rapid absorption formula (fast trot)

  • Mobility-focused supplement that combines omega fatty acids with antioxidant protection.

  • Rapid absorption formula (fast trot)

  • Mobility-focused supplement that combines omega fatty acids with antioxidant protection.

Self-Improvement & Personal Growth

Recreational Enjoyment

Omega Alpha E-Z Mobility is positioned as a specialized mobility product that integrates antioxidant support (commonly including Vitamin E, with Vitamin C often present in formulations) into a joint-focused delivery system, giving it a technical edge for dogs where oxidative stress and cartilage support are both concerns. Its advantage is targeted joint support—frequently delivered as a liquid or concentrated dose—allowing for adjunctive antioxidant therapy alongside primary mobility actives, which can be more cost-effective for pets needing focused treatment versus broad-spectrum multivitamins. In comparison with broad multivitamins like Zesty Paws or Nutri-Vet, Omega Alpha prioritizes mobility outcomes while still contributing antioxidant benefits.

  • Mobility lubricant (easy-swipe)

  • Antioxidant inflammation aid (Vit C+E zip)

  • Rapid absorption formula (fast trot)

  • Mobility-focused supplement that combines omega fatty acids with antioxidant protection.

  • Includes ingredients aimed at joint comfort while protecting oils from oxidation.

  • Mobility lubricant (easy-swipe)

  • Antioxidant inflammation aid (Vit C+E zip)

  • Rapid absorption formula (fast trot)

  • Mobility-focused supplement that combines omega fatty acids with antioxidant protection.

  • Includes ingredients aimed at joint comfort while protecting oils from oxidation.

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From 32.25$

What the Research Says About Vitamin C, Vitamin E, and Antioxidant Blends

Research in veterinary nutraceuticals and comparative physiology shows that vitamin C and vitamin E act via complementary mechanisms to neutralize free radicals and protect cellular components. In many studies, combined antioxidant strategies—especially when paired with polyphenols or probiotic strains—raise systemic antioxidant capacity, reduce markers of lipid peroxidation, and support immune cell function. While some evidence comes from controlled studies in dogs and laboratory models, other findings are drawn from broader mammalian research; overall, results suggest these blends can be a valuable adjunct to veterinary care for aging, inflammatory, or infection-prone animals when used at safe, guideline-based doses.

Antioxidant mechanisms: Vitamin E protects cell membranes from lipid peroxidation; vitamin C helps regenerate oxidized vitamin E and supports enzymatic antioxidant systems.

Biomarker improvements: Controlled studies report reductions in oxidative markers (for example, malondialdehyde) and increases in antioxidant enzymes (superoxide dismutase, glutathione peroxidase) after supplementation in affected animals.

Synergy with polyphenols and probiotics: Combining vitamins C and E with flavonoids or established probiotic strains can increase total antioxidant capacity and support immune modulation more than single-agent approaches.

Clinical relevance in small animals: Trials and clinical reports indicate potential benefits for senior pets, animals recovering from infection, and those with chronic inflammatory or degenerative conditions when used alongside standard veterinary care.

Safety and dosing: Evidence supports benefits at appropriate, veterinary-guided dosages; excessive dosing can cause gastrointestinal upset or interfere with diagnostic assays, so veterinarian consultation is recommended.

Quality matters: Studies highlight variability between formulations; products with standardized extracts, clear dosing, and third-party testing show more consistent outcomes.

In the Canadian 2025 context, antioxidant complexes that combine vitamins C and E with complementary compounds provide a practical, evidence-informed option for pet owners managing aging, immune resilience, or inflammatory concerns. The five options listed here cover a range of formats and target audiences: NaturVet VitaPet Senior Daily Vitamins Plus Glucosamine, Zesty Paws Advanced Multivitamin for Dogs, Nutri-Vet Multi-Vite Chewables for Dogs, VetriScience Canine Plus Senior Multivitamin, and Omega Alpha E-Z Mobility. For balanced antioxidant support with strong veterinary formulation and quality controls, VetriScience Canine Plus Senior Multivitamin is highlighted as our best choice among these options. We hope you found what you were looking for; refine or expand your search using the site search to compare ingredient lists, dosing guidance, or Canada-specific sourcing and testing information.

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