Pet Naturals of Vermont Calming Chews hold a strong position by offering a veterinarian-informed, straightforward herbal formulation aimed at steady, everyday support for anxious dogs at a mid-range price point. They trade a slightly narrower ingredient list for clarity and vet-oriented branding, making them a good compromise between the robust blends of Zesty Paws and the budget-focused NaturVet Quiet Moments.
Vet-formulated blend
Low-calorie calm
Vet-formulated blend
Low-calorie calm
Review Summary
"Users commonly praise steady calming effects and simple ingredients, though a few say they need higher doses for severe anxiety."
Herbal-scented chew
Veterinarian-developed chewable formula for everyday use.
Herbal-scented chew
Veterinarian-developed chewable formula for everyday use.
Increased Safety & Security
Time-Saving Convenience
Pet Naturals of Vermont Calming Chews hold a strong position by offering a veterinarian-informed, straightforward herbal formulation aimed at steady, everyday support for anxious dogs at a mid-range price point. They trade a slightly narrower ingredient list for clarity and vet-oriented branding, making them a good compromise between the robust blends of Zesty Paws and the budget-focused NaturVet Quiet Moments.
Vet-formulated blend
Low-calorie calm
Herbal-scented chew
Veterinarian-developed chewable formula for everyday use.
Contains supportive nutrients and herbal extracts targeted for anxiety relief.
Vet-formulated blend
Low-calorie calm
Herbal-scented chew
Veterinarian-developed chewable formula for everyday use.
Contains supportive nutrients and herbal extracts targeted for anxiety relief.
VetriScience Composure Pro Chews
VetriScience Composure Pro Chews earns a top position for delivering concentrated amino-acid support in a palatable, chewable format designed for acute stress events and everyday anxiety; this product emphasizes convenient administration and high owner compliance. Compared with powder or capsule competitors here, its technical advantage is a flavor-forward chew and often higher per-dose potency—making it a premium but practical choice for dogs that refuse pills or require fast-acting oral delivery.
Clinically-backed calm
Fast-acting chews
Clinically-backed calm
Fast-acting chews
Review Summary
"Owners generally praise VetriScience Composure Pro Chews as palatable and often fast-acting for travel and noise-related anxiety, though a minority report limited effect on severe, chronic issues."
Lab-coat calm
Features clinically studied L-theanine (Suntheanine) to promote relaxation without sedation.
Lab-coat calm
Features clinically studied L-theanine (Suntheanine) to promote relaxation without sedation.
Increased Safety & Security
Time-Saving Convenience
VetriScience Composure Pro Chews earns a top position for delivering concentrated amino-acid support in a palatable, chewable format designed for acute stress events and everyday anxiety; this product emphasizes convenient administration and high owner compliance. Compared with powder or capsule competitors here, its technical advantage is a flavor-forward chew and often higher per-dose potency—making it a premium but practical choice for dogs that refuse pills or require fast-acting oral delivery.
Clinically-backed calm
Fast-acting chews
Lab-coat calm
Features clinically studied L-theanine (Suntheanine) to promote relaxation without sedation.
Palatable soft chews that are easy to give daily or during acute stress events like fireworks or travel.
Clinically-backed calm
Fast-acting chews
Lab-coat calm
Features clinically studied L-theanine (Suntheanine) to promote relaxation without sedation.
Palatable soft chews that are easy to give daily or during acute stress events like fireworks or travel.
$45-85 CAD
Zesty Paws Calming Bites are positioned as a fast-acting, palatable soft chew that blends melatonin, L-theanine and hemp-derived extracts to calm anxious dogs quickly; its consistent ingredient profile and broad retail presence make it a go-to for owners seeking reliable, measurable results. Compared with the other options on this list, Zesty Paws often delivers a favorable price-per-dose thanks to wide distribution and frequent promotions, giving it a practical financial edge for multi-dog households or repeat purchasers.
Fast-acting calm
Citrus-kissed treat
Fast-acting calm
Citrus-kissed treat
Review Summary
"Most users find Zesty Paws Calming Bites tasty and effective for mild stressors like travel or thunderstorms, though a minority report little to no effect and occasional digestive upset. Overall reviewers praise palatability and consistent mild calming benefits for repeated use."
Pocket-sized zen
Soft, flavored chew designed for easy administration
Pocket-sized zen
Soft, flavored chew designed for easy administration
Increased Safety & Security
Time-Saving Convenience
Zesty Paws Calming Bites are positioned as a fast-acting, palatable soft chew that blends melatonin, L-theanine and hemp-derived extracts to calm anxious dogs quickly; its consistent ingredient profile and broad retail presence make it a go-to for owners seeking reliable, measurable results. Compared with the other options on this list, Zesty Paws often delivers a favorable price-per-dose thanks to wide distribution and frequent promotions, giving it a practical financial edge for multi-dog households or repeat purchasers.
Fast-acting calm
Citrus-kissed treat
Pocket-sized zen
Soft, flavored chew designed for easy administration
Formulated to support relaxation during travel, storms, and separation
Fast-acting calm
Citrus-kissed treat
Pocket-sized zen
Soft, flavored chew designed for easy administration
Formulated to support relaxation during travel, storms, and separation
$20-35 CAD
Zylkene is a veterinary-recommended capsule containing a milk-derived peptide (alpha-casozepine) with clinical data supporting its calming effects, which earns it a best-in-class position for dogs with situational stress. Its single, well-studied active ingredient provides a technically targeted approach compared with multi-ingredient nutraceuticals on this list, though it is typically positioned as a premium vet product and can be more costly than mass-market OTC options.
Milk-protein calm
Vet-trusted dose
Milk-protein calm
Vet-trusted dose
Review Summary
"Many owners report mild to moderate calming effects for separation anxiety and noise events after consistent use, but results vary and it's relatively pricey; generally well tolerated with few side effects."
Snooze-button capsule
Contains alpha-casozepine, a milk-derived peptide shown to promote calm behavior in stressful situations.
Snooze-button capsule
Contains alpha-casozepine, a milk-derived peptide shown to promote calm behavior in stressful situations.
Increased Safety & Security
Time-Saving Convenience
Zylkene is a veterinary-recommended capsule containing a milk-derived peptide (alpha-casozepine) with clinical data supporting its calming effects, which earns it a best-in-class position for dogs with situational stress. Its single, well-studied active ingredient provides a technically targeted approach compared with multi-ingredient nutraceuticals on this list, though it is typically positioned as a premium vet product and can be more costly than mass-market OTC options.
Milk-protein calm
Vet-trusted dose
Snooze-button capsule
Contains alpha-casozepine, a milk-derived peptide shown to promote calm behavior in stressful situations.
Capsule format allows for easy dosing and can be opened to mix with food for picky dogs.
Milk-protein calm
Vet-trusted dose
Snooze-button capsule
Contains alpha-casozepine, a milk-derived peptide shown to promote calm behavior in stressful situations.
Capsule format allows for easy dosing and can be opened to mix with food for picky dogs.
Bach Rescue Remedy Pet Liquid is the market-leading homeopathic option noted for its simplicity, low-cost per bottle and long shelf stability; it relies on flower essences to provide gentle, non-pharmacological support suited to mild stress events. Unlike the multi-ingredient powders and hemp supplements here, Rescue Remedy appeals to owners seeking a mild, widely available liquid that can be used frequently with minimal risk, making it a distinct, softer alternative to more technically active calming products.
Flower-power drops
Gentle microdoses
Flower-power drops
Gentle microdoses
Review Summary
"Owners describe Rescue Remedy as a gentle, natural option that can reduce mild stress in many pets, but results are subjective and some users see no noticeable change."
Pocket calming classic
Homeopathic flower essence blend formulated specifically for pets to support situational stress like travel or vet visits.
Pocket calming classic
Homeopathic flower essence blend formulated specifically for pets to support situational stress like travel or vet visits.
Increased Safety & Security
Self-Improvement & Personal Growth
Bach Rescue Remedy Pet Liquid is the market-leading homeopathic option noted for its simplicity, low-cost per bottle and long shelf stability; it relies on flower essences to provide gentle, non-pharmacological support suited to mild stress events. Unlike the multi-ingredient powders and hemp supplements here, Rescue Remedy appeals to owners seeking a mild, widely available liquid that can be used frequently with minimal risk, making it a distinct, softer alternative to more technically active calming products.
Flower-power drops
Gentle microdoses
Pocket calming classic
Homeopathic flower essence blend formulated specifically for pets to support situational stress like travel or vet visits.
Pet-friendly, alcohol-free liquid version available for safe use with dogs and easy mixing into food.
Flower-power drops
Gentle microdoses
Pocket calming classic
Homeopathic flower essence blend formulated specifically for pets to support situational stress like travel or vet visits.
Pet-friendly, alcohol-free liquid version available for safe use with dogs and easy mixing into food.
ThunderWunders Hemp Dog Calming Chews
ThunderWunders offers a hemp-based calming chew that appeals to owners seeking cannabinoid-supported relaxation, which can engage different biochemical pathways than traditional nutraceuticals or pheromones and may be useful as part of a multimodal plan for separation and noise phobias. Financially and technically, hemp chews often sit mid-range in price and present a unique value proposition versus prescription meds—however buyers should weigh regulatory variability and pair them thoughtfully with pheromone (Adaptil) or veterinary options (VetriScience) for best results.
Hemp hug
Thunderproof chew
Hemp hug
Thunderproof chew
Review Summary
"ThunderWunders Hemp Dog Calming Chews receive mixed feedback — some owners report meaningful improvement in thunder/noise phobia, while others see little change; potency and batch variability are common concerns."
Snackable serenity
Broad-spectrum hemp (CBD) extract blended with calming botanicals to target noise phobia and hyperarousal
Snackable serenity
Broad-spectrum hemp (CBD) extract blended with calming botanicals to target noise phobia and hyperarousal
Increased Safety & Security
Recreational Enjoyment
ThunderWunders offers a hemp-based calming chew that appeals to owners seeking cannabinoid-supported relaxation, which can engage different biochemical pathways than traditional nutraceuticals or pheromones and may be useful as part of a multimodal plan for separation and noise phobias. Financially and technically, hemp chews often sit mid-range in price and present a unique value proposition versus prescription meds—however buyers should weigh regulatory variability and pair them thoughtfully with pheromone (Adaptil) or veterinary options (VetriScience) for best results.
Hemp hug
Thunderproof chew
Snackable serenity
Broad-spectrum hemp (CBD) extract blended with calming botanicals to target noise phobia and hyperarousal
Soft, palatable chews intended for rapid onset around stressful events like thunderstorms or fireworks
Hemp hug
Thunderproof chew
Snackable serenity
Broad-spectrum hemp (CBD) extract blended with calming botanicals to target noise phobia and hyperarousal
Soft, palatable chews intended for rapid onset around stressful events like thunderstorms or fireworks