Zylkene Capsules for Dogs
Zylkene is a veterinary-recommended capsule containing a milk-derived peptide (alpha-casozepine) with clinical data supporting its calming effects, which earns it a best-in-class position for dogs with situational stress. Its single, well-studied active ingredient provides a technically targeted approach compared with multi-ingredient nutraceuticals on this list, though it is typically positioned as a premium vet product and can be more costly than mass-market OTC options.
Milk-protein calm
Vet-trusted dose
Milk-protein calm
Vet-trusted dose
Review Summary
"Many owners report mild to moderate calming effects for separation anxiety and noise events after consistent use, but results vary and it's relatively pricey; generally well tolerated with few side effects."
Snooze-button capsule
Contains alpha-casozepine, a milk-derived peptide shown to promote calm behavior in stressful situations.
Snooze-button capsule
Contains alpha-casozepine, a milk-derived peptide shown to promote calm behavior in stressful situations.
Increased Safety & Security
Time-Saving Convenience
Zylkene is a veterinary-recommended capsule containing a milk-derived peptide (alpha-casozepine) with clinical data supporting its calming effects, which earns it a best-in-class position for dogs with situational stress. Its single, well-studied active ingredient provides a technically targeted approach compared with multi-ingredient nutraceuticals on this list, though it is typically positioned as a premium vet product and can be more costly than mass-market OTC options.
Milk-protein calm
Vet-trusted dose
Snooze-button capsule
Contains alpha-casozepine, a milk-derived peptide shown to promote calm behavior in stressful situations.
Capsule format allows for easy dosing and can be opened to mix with food for picky dogs.
Milk-protein calm
Vet-trusted dose
Snooze-button capsule
Contains alpha-casozepine, a milk-derived peptide shown to promote calm behavior in stressful situations.
Capsule format allows for easy dosing and can be opened to mix with food for picky dogs.
Composure Pro Chewable Tablets
Composure Pro chewable tablets leverage Purina's formulation and research resources to deliver a palatable, widely available calming supplement that balances efficacy and cost, making it a market-leader choice for owners seeking clinic-quality support without vet-only pricing. Compared with Zylkene's single-ingredient, research-focused profile and prescription-style products like Anxitane, Composure Pro stands out for retail availability, brand-backed trials and competitive pricing across large-volume channels.
Probiotic calm boost
Chewable treat-style
Probiotic calm boost
Chewable treat-style
Review Summary
"Most users find these palatable chews provide relatively fast relief for situational anxiety (travel, storms), though some dogs show little change and effectiveness depends on dose and timing."
Pocket-sized zen
Veterinarian-formulated chewable designed for situational anxiety like storms and travel.
Pocket-sized zen
Veterinarian-formulated chewable designed for situational anxiety like storms and travel.
Increased Safety & Security
Recreational Enjoyment
Time-Saving Convenience
Composure Pro chewable tablets leverage Purina's formulation and research resources to deliver a palatable, widely available calming supplement that balances efficacy and cost, making it a market-leader choice for owners seeking clinic-quality support without vet-only pricing. Compared with Zylkene's single-ingredient, research-focused profile and prescription-style products like Anxitane, Composure Pro stands out for retail availability, brand-backed trials and competitive pricing across large-volume channels.
Probiotic calm boost
Chewable treat-style
Pocket-sized zen
Veterinarian-formulated chewable designed for situational anxiety like storms and travel.
Palatable tablet that most dogs accept without struggle, simplifying administration.
Probiotic calm boost
Chewable treat-style
Pocket-sized zen
Veterinarian-formulated chewable designed for situational anxiety like storms and travel.
Palatable tablet that most dogs accept without struggle, simplifying administration.
Anxitane Tablets
Anxitane offers a pharmaceutical-grade approach based on L-theanine and is commonly recommended by veterinarians as an adjunct or alternative to other nutraceuticals, giving it a strong technical claim for dogs with moderate anxiety. It competes with Zylkene on clinical credibility but is distinct from broader herbal blends and economy OTC tablets by focusing on a single, well-characterized calming amino acid that integrates easily with veterinary treatment plans.
L-theanine focus
Clinically studied
L-theanine focus
Clinically studied
Review Summary
"Frequently recommended by veterinarians and many owners see steady improvement in baseline anxiety with regular dosing, but some dogs show minimal response and it can be more expensive than OTC options."
Stress-halt tabs
Formulated around L-theanine, an amino acid commonly used to support relaxation without sedation.
Stress-halt tabs
Formulated around L-theanine, an amino acid commonly used to support relaxation without sedation.
Increased Safety & Security
Time-Saving Convenience
Anxitane offers a pharmaceutical-grade approach based on L-theanine and is commonly recommended by veterinarians as an adjunct or alternative to other nutraceuticals, giving it a strong technical claim for dogs with moderate anxiety. It competes with Zylkene on clinical credibility but is distinct from broader herbal blends and economy OTC tablets by focusing on a single, well-characterized calming amino acid that integrates easily with veterinary treatment plans.
L-theanine focus
Clinically studied
Stress-halt tabs
Formulated around L-theanine, an amino acid commonly used to support relaxation without sedation.
Tablet form permits straightforward dosing and is often used for both situational and ongoing anxiety.
L-theanine focus
Clinically studied
Stress-halt tabs
Formulated around L-theanine, an amino acid commonly used to support relaxation without sedation.
Tablet form permits straightforward dosing and is often used for both situational and ongoing anxiety.
Solliquin Chewable Tablets
Solliquin is a mid-range, chewable calming tablet built around a multi-ingredient nutraceutical strategy aimed at longer-term behavior support, making it a market leader for owners who prefer synergistic formulations over single-actives. Its value proposition is the combination of palatability and sustained behavioral support, which positions it between premium, vet-prescribed options and the lowest-cost OTC remedies in both technical breadth and price.
Multi-ingredient blend
Tasty chewable form
Multi-ingredient blend
Tasty chewable form
Review Summary
"Widely regarded for consistent calming effects and good palatability; many report noticeable behavioral improvements over time, though a minority of pets do not respond."
Calm, not sedated
Combines multiple calming-support ingredients in a tasty chew for broader behavioral support.
Calm, not sedated
Combines multiple calming-support ingredients in a tasty chew for broader behavioral support.
Increased Safety & Security
Time-Saving Convenience
Solliquin is a mid-range, chewable calming tablet built around a multi-ingredient nutraceutical strategy aimed at longer-term behavior support, making it a market leader for owners who prefer synergistic formulations over single-actives. Its value proposition is the combination of palatability and sustained behavioral support, which positions it between premium, vet-prescribed options and the lowest-cost OTC remedies in both technical breadth and price.
Multi-ingredient blend
Tasty chewable form
Calm, not sedated
Combines multiple calming-support ingredients in a tasty chew for broader behavioral support.
Developed by a veterinary supplement maker with a track record in joint and behavior products.
Multi-ingredient blend
Tasty chewable form
Calm, not sedated
Combines multiple calming-support ingredients in a tasty chew for broader behavioral support.
Developed by a veterinary supplement maker with a track record in joint and behavior products.
$40-90 CAD
NaturVet Quiet Moments Calming Aid Tablets
NaturVet Quiet Moments is an affordable, widely distributed calming tablet geared to owners looking for an accessible OTC option for mild stressors; its price and retail availability are its chief advantages for routine use. While it lacks the concentrated clinical backing of Zylkene or Anxitane and the branded research of Composure Pro, its low cost and easy purchase make it a practical first-step option before escalating to vet-grade products.
Herbal melatonin mix
Budget-friendly calm
Herbal melatonin mix
Budget-friendly calm
Review Summary
"Budget-friendly and widely available, some owners report reduced anxiety and improved sleep while others find little effect or mild sedation; results are mixed across users."
Snackable serenity
Economical, over-the-counter tablets suitable for owners seeking an affordable calming aid.
Snackable serenity
Economical, over-the-counter tablets suitable for owners seeking an affordable calming aid.
Increased Safety & Security
Time-Saving Convenience
NaturVet Quiet Moments is an affordable, widely distributed calming tablet geared to owners looking for an accessible OTC option for mild stressors; its price and retail availability are its chief advantages for routine use. While it lacks the concentrated clinical backing of Zylkene or Anxitane and the branded research of Composure Pro, its low cost and easy purchase make it a practical first-step option before escalating to vet-grade products.
Herbal melatonin mix
Budget-friendly calm
Snackable serenity
Economical, over-the-counter tablets suitable for owners seeking an affordable calming aid.
Easy-to-give tablets designed for occasional situational stress like travel or fireworks.
Herbal melatonin mix
Budget-friendly calm
Snackable serenity
Economical, over-the-counter tablets suitable for owners seeking an affordable calming aid.
Easy-to-give tablets designed for occasional situational stress like travel or fireworks.