Antisedan (atipamezole)
Antisedan is the veterinary standard atipamezole product for reversing alpha-2 agonist sedation in dogs, valued for rapid, predictable recovery and broad veterinary labeling. Compared with other agents on this list, Antisedan's manufacturer support, established clinical track record and widespread availability give it a technical and commercial advantage for clinic-based anesthetic reversal, while its mechanism is complementary—not interchangeable—with opioid and benzodiazepine antagonists.
Rapid wake-up — quick!
Alpha-selective reversal — tidy!
Rapid wake-up — quick!
Alpha-selective reversal — tidy!
Review Summary
"Users report Antisedan (atipamezole) reliably reverses alpha-2 agonist sedation in dogs with rapid recovery and generally predictable effects; occasional injection-site reactions and transient agitation are the most commonly noted issues. Overall it's considered a dependable veterinary reversal when dosed appropriately."
Predictable recovery — calm!
Specific alpha-2 antagonist licensed for reversing medetomidine/dexmedetomidine in dogs.
Predictable recovery — calm!
Specific alpha-2 antagonist licensed for reversing medetomidine/dexmedetomidine in dogs.
Increased Safety & Security
Time-Saving Convenience
Antisedan is the veterinary standard atipamezole product for reversing alpha-2 agonist sedation in dogs, valued for rapid, predictable recovery and broad veterinary labeling. Compared with other agents on this list, Antisedan's manufacturer support, established clinical track record and widespread availability give it a technical and commercial advantage for clinic-based anesthetic reversal, while its mechanism is complementary—not interchangeable—with opioid and benzodiazepine antagonists.
Rapid wake-up — quick!
Alpha-selective reversal — tidy!
Predictable recovery — calm!
Specific alpha-2 antagonist licensed for reversing medetomidine/dexmedetomidine in dogs.
Typically given IM with rapid onset of clinical recovery within minutes.
Rapid wake-up — quick!
Alpha-selective reversal — tidy!
Predictable recovery — calm!
Specific alpha-2 antagonist licensed for reversing medetomidine/dexmedetomidine in dogs.
Typically given IM with rapid onset of clinical recovery within minutes.
$80-160 CAD
Naloxone Injection USP
Naloxone Injection USP is a low-cost, generic opioid antagonist widely used to reverse opioid-induced sedation and respiratory depression in dogs and is prized for flexible IV/IM/SC administration in clinical settings. Compared with branded intranasal formulations it is generally less expensive per dose and more versatile for monitored veterinary use, though it lacks the noninvasive administration advantage of nasal sprays used in field or owner-administered rescues.
Opioid reversal — instant!
Restores respiration — lifesaver!
Opioid reversal — instant!
Restores respiration — lifesaver!
Review Summary
"Naloxone Injection USP is widely praised for promptly reversing opioid effects in veterinary patients, with most users noting fast onset and clear improvement; some report the need for repeat dosing due to naloxone's shorter duration than certain opioids. It is regarded as an essential, effective emergency agent."
EMT-ready solution — steady!
Pure opioid antagonist that quickly reverses opioid-induced respiratory depression in dogs.
EMT-ready solution — steady!
Pure opioid antagonist that quickly reverses opioid-induced respiratory depression in dogs.
Increased Safety & Security
Time-Saving Convenience
Naloxone Injection USP is a low-cost, generic opioid antagonist widely used to reverse opioid-induced sedation and respiratory depression in dogs and is prized for flexible IV/IM/SC administration in clinical settings. Compared with branded intranasal formulations it is generally less expensive per dose and more versatile for monitored veterinary use, though it lacks the noninvasive administration advantage of nasal sprays used in field or owner-administered rescues.
Opioid reversal — instant!
Restores respiration — lifesaver!
EMT-ready solution — steady!
Pure opioid antagonist that quickly reverses opioid-induced respiratory depression in dogs.
Available as injectable formulation for IV/IM/SQ administration in emergency or perioperative settings.
Opioid reversal — instant!
Restores respiration — lifesaver!
EMT-ready solution — steady!
Pure opioid antagonist that quickly reverses opioid-induced respiratory depression in dogs.
Available as injectable formulation for IV/IM/SQ administration in emergency or perioperative settings.
$30-80 CAD
Flumazenil Injection
Flumazenil Injection is the specific benzodiazepine antagonist used to reverse benzodiazepine-induced sedation in dogs, providing rapid and targeted reversal when benzodiazepines are involved in the anesthetic protocol. Its technical strength is this specificity—making it indispensable in mixed-drug cases where neither atipamezole nor naloxone would be effective—though it tends to be a more specialized, sometimes higher-cost agent with a narrower clinical niche.
Benzodiazepine antidote — sharp!
Rapid arousal — focused!
Benzodiazepine antidote — sharp!
Rapid arousal — focused!
Review Summary
"Flumazenil Injection is effective at reversing benzodiazepine-induced sedation in dogs but reviewers frequently mention limited availability, higher cost, and a shorter action that can require monitoring for resedation. Users appreciate its targeted action but note mixed practical experience due to access and duration concerns."
Short action window — controllable!
Selective benzodiazepine antagonist used to reverse sedative effects of benzodiazepines in dogs.
Short action window — controllable!
Selective benzodiazepine antagonist used to reverse sedative effects of benzodiazepines in dogs.
Increased Safety & Security
Time-Saving Convenience
Flumazenil Injection is the specific benzodiazepine antagonist used to reverse benzodiazepine-induced sedation in dogs, providing rapid and targeted reversal when benzodiazepines are involved in the anesthetic protocol. Its technical strength is this specificity—making it indispensable in mixed-drug cases where neither atipamezole nor naloxone would be effective—though it tends to be a more specialized, sometimes higher-cost agent with a narrower clinical niche.
Benzodiazepine antidote — sharp!
Rapid arousal — focused!
Short action window — controllable!
Selective benzodiazepine antagonist used to reverse sedative effects of benzodiazepines in dogs.
Given IV with rapid onset to restore mentation and respiratory drive.
Benzodiazepine antidote — sharp!
Rapid arousal — focused!
Short action window — controllable!
Selective benzodiazepine antagonist used to reverse sedative effects of benzodiazepines in dogs.
Given IV with rapid onset to restore mentation and respiratory drive.
$60-120 CAD
Narcan Nasal Spray
Narcan Nasal Spray is a branded naloxone product formulated for easy, noninvasive intranasal rescue of opioid effects and is useful for rapid field or owner-administered intervention in dogs exposed to opioids. Compared with injectable naloxone it trades some dosing flexibility for simplicity and speed of administration, and while typically more expensive per unit, its usability can reduce time-to-treatment outside the clinic.
Needle-free rescue — easy!
Fast nasal onset — zippy!
Needle-free rescue — easy!
Fast nasal onset — zippy!
Review Summary
"Narcan Nasal Spray receives strong praise for ease of use and rapid opioid reversal in emergency situations; buyers cite high reliability and usefulness for first-response situations, though some mention cost and occasional need for multiple doses. It is highly rated for accessibility and life-saving potential."
Carry-and-deploy — public-ready!
User-friendly intranasal naloxone spray suitable for rapid opioid reversal in emergency canine cases.
Carry-and-deploy — public-ready!
User-friendly intranasal naloxone spray suitable for rapid opioid reversal in emergency canine cases.
Increased Safety & Security
Time-Saving Convenience
Narcan Nasal Spray is a branded naloxone product formulated for easy, noninvasive intranasal rescue of opioid effects and is useful for rapid field or owner-administered intervention in dogs exposed to opioids. Compared with injectable naloxone it trades some dosing flexibility for simplicity and speed of administration, and while typically more expensive per unit, its usability can reduce time-to-treatment outside the clinic.
Needle-free rescue — easy!
Fast nasal onset — zippy!
Carry-and-deploy — public-ready!
User-friendly intranasal naloxone spray suitable for rapid opioid reversal in emergency canine cases.
Non-invasive administration helpful when IV/IM access is difficult; often used off-label in veterinary practice.
Needle-free rescue — easy!
Fast nasal onset — zippy!
Carry-and-deploy — public-ready!
User-friendly intranasal naloxone spray suitable for rapid opioid reversal in emergency canine cases.
Non-invasive administration helpful when IV/IM access is difficult; often used off-label in veterinary practice.
$40-80 CAD
Revertor (atipamezole)
Revertor is an alternative atipamezole preparation for reversing alpha-2 agonists in dogs that offers similar pharmacologic efficacy to other atipamezole brands while often competing on regional price or vial-size options. Against Antisedan, Revertor can represent a cost-competitive choice for practices in certain markets or supply chains, though it may have less global brand recognition and variable availability depending on the distributor.
Swift reversal — reliable!
Veterinary staple — classic!
Swift reversal — reliable!
Veterinary staple — classic!
Review Summary
"Revertor (atipamezole) is generally viewed as an effective alternative to Antisedan for reversing alpha-2 agonists in dogs, producing reliable recovery with similar side-effect profiles; a few users note variability between formulations and occasional supply issues. Overall it is well-regarded by clinicians and owners familiar with repeated use."
Precise dosing — consistent!
Generic atipamezole formulation that provides the same alpha-2 antagonism as branded options at lower cost.
Precise dosing — consistent!
Generic atipamezole formulation that provides the same alpha-2 antagonism as branded options at lower cost.
Increased Safety & Security
Time-Saving Convenience
Revertor is an alternative atipamezole preparation for reversing alpha-2 agonists in dogs that offers similar pharmacologic efficacy to other atipamezole brands while often competing on regional price or vial-size options. Against Antisedan, Revertor can represent a cost-competitive choice for practices in certain markets or supply chains, though it may have less global brand recognition and variable availability depending on the distributor.
Swift reversal — reliable!
Veterinary staple — classic!
Precise dosing — consistent!
Generic atipamezole formulation that provides the same alpha-2 antagonism as branded options at lower cost.
Administered IM to reverse alpha-2 agonist sedation in dogs with comparable efficacy.
Swift reversal — reliable!
Veterinary staple — classic!
Precise dosing — consistent!
Generic atipamezole formulation that provides the same alpha-2 antagonism as branded options at lower cost.
Administered IM to reverse alpha-2 agonist sedation in dogs with comparable efficacy.
$50-110 CAD