Sileo Oromucosal Gel
Sileo is the market-leading transmucosal dexmedetomidine gel designed specifically for rapid, situational sedation in dogs and stands out for its mucosal absorption and fast onset compared with oral tablet options. For the oral and transmucosal sedative use case it offers predictable, short-duration effects ideal for noise or situational anxiety, though it is typically priced higher than generic oral agents and is used more for acute events than chronic management.
Rapid calm onset
Easy buccal dosing
Rapid calm onset
Easy buccal dosing
Review Summary
"Sileo oromucosal gel is widely praised for reliably reducing noise-phobia and situational anxiety in dogs with quick onset and easy administration, though some pets experience mild to moderate sedation, drooling or vomiting. Owners appreciate the targeted, veterinarian-prescribed formulation but note cost and need for supervision after dosing."
Fireworks whisperer
Alpha-2 adrenergic agonist gel formulated for oromucosal administration to rapidly reduce noise-related anxiety in dogs.
Fireworks whisperer
Alpha-2 adrenergic agonist gel formulated for oromucosal administration to rapidly reduce noise-related anxiety in dogs.
Increased Safety & Security
Recreational Enjoyment
Time-Saving Convenience
Sileo is the market-leading transmucosal dexmedetomidine gel designed specifically for rapid, situational sedation in dogs and stands out for its mucosal absorption and fast onset compared with oral tablet options. For the oral and transmucosal sedative use case it offers predictable, short-duration effects ideal for noise or situational anxiety, though it is typically priced higher than generic oral agents and is used more for acute events than chronic management.
Rapid calm onset
Easy buccal dosing
Fireworks whisperer
Alpha-2 adrenergic agonist gel formulated for oromucosal administration to rapidly reduce noise-related anxiety in dogs.
Fast onset (often within 10–30 minutes) and relatively short duration suitable for acute events like fireworks or thunderstorms.
Rapid calm onset
Easy buccal dosing
Fireworks whisperer
Alpha-2 adrenergic agonist gel formulated for oromucosal administration to rapidly reduce noise-related anxiety in dogs.
Fast onset (often within 10–30 minutes) and relatively short duration suitable for acute events like fireworks or thunderstorms.
$60-150 CAD
Gabapentin Oral Solution
Gabapentin oral solution is a cost-effective, easily titratable option commonly used off-label for anxiolysis and mild sedation in dogs, and its liquid form facilitates dose adjustments for small or difficult-to-medicate patients compared with fixed-dose tablets. While not as potently sedating as dexmedetomidine-based transmucosal formulations like Sileo, its lower price and favorable safety profile make it attractive for repeated or at-home situational use and multimodal regimens.
Liquid flexibility
Quick pre-visit calm
Liquid flexibility
Quick pre-visit calm
Review Summary
"Gabapentin oral solution is commonly reported as an effective off-label option for anxiety and chronic pain control, offering flexible dosing and rapid calming, but many users report sedation and occasional ataxia at higher doses. Reviewers value its convenience for small or pill-averse dogs, though some find variable efficacy for severe anxiety."
Car-ride co-pilot
Gabapentin provides mild to moderate sedation and neuropathic pain control, commonly used as an adjunct for peri-procedural calming.
Car-ride co-pilot
Gabapentin provides mild to moderate sedation and neuropathic pain control, commonly used as an adjunct for peri-procedural calming.
Increased Safety & Security
Time-Saving Convenience
Gabapentin oral solution is a cost-effective, easily titratable option commonly used off-label for anxiolysis and mild sedation in dogs, and its liquid form facilitates dose adjustments for small or difficult-to-medicate patients compared with fixed-dose tablets. While not as potently sedating as dexmedetomidine-based transmucosal formulations like Sileo, its lower price and favorable safety profile make it attractive for repeated or at-home situational use and multimodal regimens.
Liquid flexibility
Quick pre-visit calm
Car-ride co-pilot
Gabapentin provides mild to moderate sedation and neuropathic pain control, commonly used as an adjunct for peri-procedural calming.
Oral liquid formulation allows flexible dose titration and easy administration to dogs (and mixes into food if needed).
Liquid flexibility
Quick pre-visit calm
Car-ride co-pilot
Gabapentin provides mild to moderate sedation and neuropathic pain control, commonly used as an adjunct for peri-procedural calming.
Oral liquid formulation allows flexible dose titration and easy administration to dogs (and mixes into food if needed).
$20-60 CAD
Trazodone Chewable Tablets
Trazodone chewables provide a palatable, moderately fast-acting oral sedative/anxiolytic that is valuable for pre-visit or short-term situational use and pairs well with other agents for enhanced effect; the chewable format improves compliance over formulations requiring compounding. Compared with long-term antidepressants in this list, trazodone offers a more immediate effect with lower acquisition cost than branded transmucosal products, though it generally serves best as an adjunct rather than a sole long-term therapy.
Chewable ease
Extended mellow time
Chewable ease
Extended mellow time
Review Summary
"Trazodone chewable tablets receive consistent praise for controlling situational anxiety and facilitating post-surgical confinement, with many owners noting predictable calming effects; however, extended sedation and variable individual response are common concerns. The chewable formulation is favored for easy administration but requires dose titration by a vet."
Vet-trip lifesaver
Trazodone offers sedative and anxiolytic effects useful for situational stressors such as vet visits, travel, or acute events.
Vet-trip lifesaver
Trazodone offers sedative and anxiolytic effects useful for situational stressors such as vet visits, travel, or acute events.
Increased Safety & Security
Time-Saving Convenience
Trazodone chewables provide a palatable, moderately fast-acting oral sedative/anxiolytic that is valuable for pre-visit or short-term situational use and pairs well with other agents for enhanced effect; the chewable format improves compliance over formulations requiring compounding. Compared with long-term antidepressants in this list, trazodone offers a more immediate effect with lower acquisition cost than branded transmucosal products, though it generally serves best as an adjunct rather than a sole long-term therapy.
Chewable ease
Extended mellow time
Vet-trip lifesaver
Trazodone offers sedative and anxiolytic effects useful for situational stressors such as vet visits, travel, or acute events.
Chewable tablets enable straightforward oral dosing with onset typically within 30–60 minutes and duration appropriate for same-day events.
Chewable ease
Extended mellow time
Vet-trip lifesaver
Trazodone offers sedative and anxiolytic effects useful for situational stressors such as vet visits, travel, or acute events.
Chewable tablets enable straightforward oral dosing with onset typically within 30–60 minutes and duration appropriate for same-day events.
$25-70 CAD
Clomicalm Tablets
Clomicalm (clomipramine) is a veterinary-labelled tricyclic antidepressant marketed for chronic anxiety disorders in dogs, offering robust clinical data and label-specific dosing that supports predictable long-term management unlike many off-label oral sedatives. Its principal advantage for this use case is sustained efficacy for conditions such as separation anxiety, though it has a slower onset and often higher per-unit cost than generic sedatives used for acute events.
Separation specialist
Daily routine pill
Separation specialist
Daily routine pill
Review Summary
"Clomicalm (clomipramine) is generally regarded as effective for separation anxiety in many dogs when given chronically, with owners reporting gradual behavioral improvement, though it often requires weeks to months and monitoring for anticholinergic side effects. Some users note cost and the need for bloodwork or dose adjustments as downsides."
Calm-focus boost
Clomipramine (Clomicalm) is a tricyclic antidepressant licensed for canine separation anxiety with evidence of efficacy.
Calm-focus boost
Clomipramine (Clomicalm) is a tricyclic antidepressant licensed for canine separation anxiety with evidence of efficacy.
Increased Safety & Security
Self-Improvement & Personal Growth
Clomicalm (clomipramine) is a veterinary-labelled tricyclic antidepressant marketed for chronic anxiety disorders in dogs, offering robust clinical data and label-specific dosing that supports predictable long-term management unlike many off-label oral sedatives. Its principal advantage for this use case is sustained efficacy for conditions such as separation anxiety, though it has a slower onset and often higher per-unit cost than generic sedatives used for acute events.
Separation specialist
Daily routine pill
Calm-focus boost
Clomipramine (Clomicalm) is a tricyclic antidepressant licensed for canine separation anxiety with evidence of efficacy.
Oral tablets are given daily with effects developing over weeks and are best combined with behavioral modification strategies.
Separation specialist
Daily routine pill
Calm-focus boost
Clomipramine (Clomicalm) is a tricyclic antidepressant licensed for canine separation anxiety with evidence of efficacy.
Oral tablets are given daily with effects developing over weeks and are best combined with behavioral modification strategies.
$60-140 CAD
Reconcile Chewable Tablets
Reconcile (fluoxetine) chewables are a veterinary-approved selective serotonin reuptake inhibitor for long-term control of anxiety-related behaviors in dogs, providing convenient once-daily dosing and cost efficiencies for chronic therapy compared with frequent-use transmucosal products. In the oral/transmucosal sedative landscape, Reconcile is less useful for acute situational sedation than Sileo or trazodone but is financially and technically advantageous for clinicians seeking an evidence-based, chewable maintenance option.
Mood steadying chew
Tasty daily routine
Mood steadying chew
Tasty daily routine
Review Summary
"Reconcile (fluoxetine chewable tablets) is frequently reported to help reduce separation-related compulsive and anxiety behaviors over weeks of use, with a good proportion of owners noting substantial improvement; common complaints include GI upset, lethargy, and the delayed onset of action. The chewable form improves compliance, but not all dogs respond and combination therapy is often recommended."
Owner peace prize
Fluoxetine (Reconcile) is an SSRI approved for long-term management of separation anxiety and other chronic behavioral disorders in dogs.
Owner peace prize
Fluoxetine (Reconcile) is an SSRI approved for long-term management of separation anxiety and other chronic behavioral disorders in dogs.
Increased Safety & Security
Self-Improvement & Personal Growth
Reconcile (fluoxetine) chewables are a veterinary-approved selective serotonin reuptake inhibitor for long-term control of anxiety-related behaviors in dogs, providing convenient once-daily dosing and cost efficiencies for chronic therapy compared with frequent-use transmucosal products. In the oral/transmucosal sedative landscape, Reconcile is less useful for acute situational sedation than Sileo or trazodone but is financially and technically advantageous for clinicians seeking an evidence-based, chewable maintenance option.
Mood steadying chew
Tasty daily routine
Owner peace prize
Fluoxetine (Reconcile) is an SSRI approved for long-term management of separation anxiety and other chronic behavioral disorders in dogs.
Chewable tablets improve compliance; therapeutic benefits typically emerge over 4–6 weeks of daily dosing.
Mood steadying chew
Tasty daily routine
Owner peace prize
Fluoxetine (Reconcile) is an SSRI approved for long-term management of separation anxiety and other chronic behavioral disorders in dogs.
Chewable tablets improve compliance; therapeutic benefits typically emerge over 4–6 weeks of daily dosing.
$50-120 CAD