Palladia (Toceranib)
Palladia is recognized as a best-in-class veterinary tyrosine kinase inhibitor developed and labeled specifically for dogs with mast cell disease, giving it a clinical and regulatory advantage in veterinary oncology practice. Compared with other agents on this list it offers a veterinary-tailored formulation and long track record in canine care, simplifying prescribing and clinic workflows versus human-origin medications; financially, its established place in protocols supports predictable purchasing and supply for clinics.
Oral tumor control
Mast-cell precision
Oral tumor control
Mast-cell precision
Review Summary
"Owners and veterinarians report meaningful tumor control in many dogs with mast cell tumors, often extending quality of life, but frequent side effects (vomiting, diarrhea, neutropenia, liver enzyme changes) and variable response rates temper enthusiasm."
Pill with bite
Oral tyrosine kinase inhibitor specifically approved for canine mast cell tumors.
Pill with bite
Oral tyrosine kinase inhibitor specifically approved for canine mast cell tumors.
Increased Safety & Security
Time-Saving Convenience
Palladia is recognized as a best-in-class veterinary tyrosine kinase inhibitor developed and labeled specifically for dogs with mast cell disease, giving it a clinical and regulatory advantage in veterinary oncology practice. Compared with other agents on this list it offers a veterinary-tailored formulation and long track record in canine care, simplifying prescribing and clinic workflows versus human-origin medications; financially, its established place in protocols supports predictable purchasing and supply for clinics.
Oral tumor control
Mast-cell precision
Pill with bite
Oral tyrosine kinase inhibitor specifically approved for canine mast cell tumors.
Targets KIT, PDGFR and VEGFR pathways for antitumor activity.
Oral tumor control
Mast-cell precision
Pill with bite
Oral tyrosine kinase inhibitor specifically approved for canine mast cell tumors.
Targets KIT, PDGFR and VEGFR pathways for antitumor activity.
$300-700 CAD
Masivet (Masitinib)
Masivet is a market-leading veterinary TKI with a distinct kinase selectivity profile that has gained traction in Europe for canine mast cell tumors and other indications, often positioned as a complementary option to toceranib. Technically it provides an alternative mechanism and tolerability profile to Palladia, and commercially it can be competitive on pricing in key markets, offering clinics a choice when tailoring targeted therapy.
KIT mutation targeting
Chewable dosing
KIT mutation targeting
Chewable dosing
Review Summary
"Masitinib produces tumor responses in a subset of dogs, particularly for mast cell tumors, but inconsistent availability, cost and notable side effects (GI upset, liver changes, proteinuria) lead to mixed long-term satisfaction."
Pocket-sized protector
Oral masitinib formulation used for canine mast cell tumor management under vet supervision.
Pocket-sized protector
Oral masitinib formulation used for canine mast cell tumor management under vet supervision.
Increased Safety & Security
Time-Saving Convenience
Masivet is a market-leading veterinary TKI with a distinct kinase selectivity profile that has gained traction in Europe for canine mast cell tumors and other indications, often positioned as a complementary option to toceranib. Technically it provides an alternative mechanism and tolerability profile to Palladia, and commercially it can be competitive on pricing in key markets, offering clinics a choice when tailoring targeted therapy.
KIT mutation targeting
Chewable dosing
Pocket-sized protector
Oral masitinib formulation used for canine mast cell tumor management under vet supervision.
Selective KIT inhibition with an alternative side-effect profile to other TKIs.
KIT mutation targeting
Chewable dosing
Pocket-sized protector
Oral masitinib formulation used for canine mast cell tumor management under vet supervision.
Selective KIT inhibition with an alternative side-effect profile to other TKIs.
$250-600 CAD
Oncaspar (L-asparaginase)
Oncaspar is a pegylated L-asparaginase used primarily for lymphoid malignancies that brings the technical advantage of prolonged activity and reduced dosing frequency versus non-pegylated formulations, which can lower administration burden for canine patients. In a veterinary oncology formulary it complements TKIs like Palladia and Masivet by targeting hematologic cancers rather than solid tumors, and although its acquisition cost can be higher, fewer administrations can reduce overall clinic time and supportive-care costs.
Enzyme lymphoma hit
Quick single-dose
Enzyme lymphoma hit
Quick single-dose
Review Summary
"Pegylated L-asparaginase is often seen as effective for inducing remission in canine lymphoma protocols with rapid initial responses, though hypersensitivity reactions and injection-related issues reduce overall favorability for some owners."
Stealthy protein zap
Pegylated L-asparaginase injectable used as part of multi-agent lymphoma chemotherapy protocols.
Stealthy protein zap
Pegylated L-asparaginase injectable used as part of multi-agent lymphoma chemotherapy protocols.
Increased Safety & Security
Time-Saving Convenience
Oncaspar is a pegylated L-asparaginase used primarily for lymphoid malignancies that brings the technical advantage of prolonged activity and reduced dosing frequency versus non-pegylated formulations, which can lower administration burden for canine patients. In a veterinary oncology formulary it complements TKIs like Palladia and Masivet by targeting hematologic cancers rather than solid tumors, and although its acquisition cost can be higher, fewer administrations can reduce overall clinic time and supportive-care costs.
Enzyme lymphoma hit
Quick single-dose
Stealthy protein zap
Pegylated L-asparaginase injectable used as part of multi-agent lymphoma chemotherapy protocols.
Provides rapid depletion of circulating asparagine to target lymphoid tumors.
Enzyme lymphoma hit
Quick single-dose
Stealthy protein zap
Pegylated L-asparaginase injectable used as part of multi-agent lymphoma chemotherapy protocols.
Provides rapid depletion of circulating asparagine to target lymphoid tumors.
$300-800 CAD
Cerenia (Maropitant)
Cerenia is a veterinary-labeled antiemetic specifically approved for dogs and is widely adopted in chemotherapy protocols to prevent nausea and vomiting, giving it a regulatory and formulation advantage over human antiemetics. As supportive care for patients receiving cytotoxic or targeted therapies (such as Oncaspar, Palladia or Masivet) it integrates readily into clinic workflows and is often preferred for its canine-specific dosing and packaging, which can reduce medication errors and associated costs.
Stops vomiting fast
Motion-sickness helper
Stops vomiting fast
Motion-sickness helper
Review Summary
"Maropitant is widely praised as a reliable, well-tolerated antiemetic for dogs, delivering excellent control of acute and chemotherapy-induced vomiting with high owner and clinician satisfaction."
Car-ride calm
Maropitant injectable or oral formulation commonly used to prevent chemotherapy-induced vomiting in dogs.
Car-ride calm
Maropitant injectable or oral formulation commonly used to prevent chemotherapy-induced vomiting in dogs.
Recreational Enjoyment
Increased Safety & Security
Cerenia is a veterinary-labeled antiemetic specifically approved for dogs and is widely adopted in chemotherapy protocols to prevent nausea and vomiting, giving it a regulatory and formulation advantage over human antiemetics. As supportive care for patients receiving cytotoxic or targeted therapies (such as Oncaspar, Palladia or Masivet) it integrates readily into clinic workflows and is often preferred for its canine-specific dosing and packaging, which can reduce medication errors and associated costs.
Stops vomiting fast
Motion-sickness helper
Car-ride calm
Maropitant injectable or oral formulation commonly used to prevent chemotherapy-induced vomiting in dogs.
Acts as an NK1 receptor antagonist providing broad antiemetic coverage.
Stops vomiting fast
Motion-sickness helper
Car-ride calm
Maropitant injectable or oral formulation commonly used to prevent chemotherapy-induced vomiting in dogs.
Acts as an NK1 receptor antagonist providing broad antiemetic coverage.
$30-120 CAD
Zofran (Ondansetron)
Zofran is a broadly available human antiemetic frequently used off-label in dogs for chemotherapy-induced nausea and offers a clear financial advantage in many markets due to generic availability. While it lacks veterinary-specific labeling and dedicated canine formulations like Cerenia, its low per-dose cost and wide availability make it a practical supportive-care option when clinics need an economical alternative or when maropitant is contraindicated.
Chemo nausea control
Rapid antiemetic
Chemo nausea control
Rapid antiemetic
Review Summary
"Ondansetron is commonly used off-label for chemo-related and severe nausea in dogs and is generally effective; some users find it slightly less broad or potent than maropitant for certain causes, but overall feedback is positive."
Taste-saver tablet
Ondansetron is a 5-HT3 antagonist used off-label to control nausea and vomiting in canine chemotherapy patients.
Taste-saver tablet
Ondansetron is a 5-HT3 antagonist used off-label to control nausea and vomiting in canine chemotherapy patients.
Increased Safety & Security
Recreational Enjoyment
Zofran is a broadly available human antiemetic frequently used off-label in dogs for chemotherapy-induced nausea and offers a clear financial advantage in many markets due to generic availability. While it lacks veterinary-specific labeling and dedicated canine formulations like Cerenia, its low per-dose cost and wide availability make it a practical supportive-care option when clinics need an economical alternative or when maropitant is contraindicated.
Chemo nausea control
Rapid antiemetic
Taste-saver tablet
Ondansetron is a 5-HT3 antagonist used off-label to control nausea and vomiting in canine chemotherapy patients.
Available in tablet and injectable forms and often less costly than veterinary-labelled antiemetics.
Chemo nausea control
Rapid antiemetic
Taste-saver tablet
Ondansetron is a 5-HT3 antagonist used off-label to control nausea and vomiting in canine chemotherapy patients.
Available in tablet and injectable forms and often less costly than veterinary-labelled antiemetics.
$25-100 CAD